New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs
Identifieur interne : 001A51 ( Main/Exploration ); précédent : 001A50; suivant : 001A52New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs
Auteurs : Dominik Sturm [Allemagne] ; Brent A. Orr [États-Unis] ; Umut H. Toprak [Allemagne] ; Volker Hovestadt [Allemagne] ; David T. W. Jones [Allemagne] ; David Capper [Allemagne] ; Martin Sill [Allemagne] ; Ivo Buchhalter [Allemagne] ; Paul A. Northcott [Allemagne] ; Irina Leis [Allemagne] ; Marina Ryzhova [Russie] ; Christian Koelsche [Allemagne] ; Elke Pfaff [Allemagne] ; Sariah J. Allen [États-Unis] ; Gnanaprakash Balasubramanian [Allemagne] ; Barbara C. Worst [Allemagne] ; Kristian W. Pajtler [Allemagne] ; Sebastian Brabetz [Allemagne] ; Pascal D. Johann [Allemagne] ; Felix Sahm [Allemagne] ; Jüri Reimand [Canada] ; Alan Mackay [Royaume-Uni] ; Diana M. Carvalho [Royaume-Uni] ; Marc Remke [Canada] ; Joanna J. Phillips [États-Unis] ; Arie Perry [États-Unis] ; Cynthia Cowdrey [États-Unis] ; Rachid Drissi [États-Unis] ; Maryam Fouladi [États-Unis] ; Felice Giangaspero [Italie] ; Maria Łastowska [Pologne] ; Wiesława Grajkowska [Pologne] ; Wolfram Scheurlen [Allemagne] ; Torsten Pietsch [Allemagne] ; Christian Hagel [Allemagne] ; Johannes Gojo [Autriche] ; Daniela Lötsch [Autriche] ; Walter Berger [Autriche] ; Irene Slavc [Autriche] ; Christine Haberler [Autriche] ; Anne Jouvet [France] ; Stefan Holm [Suède] ; Silvia Hofer [Suisse] ; Marco Prinz [Allemagne] ; Catherine Keohane [Irlande (pays)] ; Iris Fried [Israël] ; Christian Mawrin [Allemagne] ; David Scheie [Danemark] ; Bret C. Mobley [États-Unis] ; Matthew J. Schniederjan [États-Unis] ; Mariarita Santi [États-Unis] ; Anna M. Buccoliero [Italie] ; Sonika Dahiya [États-Unis] ; Christof M. Kramm [Allemagne] ; André O. Von Bueren [Allemagne] ; Katja Von Hoff [Allemagne] ; Stefan Rutkowski [Allemagne] ; Christel Herold-Mende [Allemagne] ; Michael C. Frühwald [Allemagne] ; Till Milde [Allemagne] ; Martin Hasselblatt [Allemagne] ; Pieter Wesseling [Pays-Bas] ; Jochen Rö Ler [Allemagne] ; Ulrich Schüller [Allemagne] ; Martin Ebinger [Allemagne] ; Jens Schittenhelm [Allemagne] ; Stephan Frank [Suisse] ; Rainer Grobholz [Suisse] ; Istvan Vajtai [Suisse] ; Volkmar Hans [Allemagne] ; Reinhard Schneppenheim [Allemagne] ; Karel Zitterbart [République tchèque] ; V. Peter Collins [Royaume-Uni] ; Eleonora Aronica [Pays-Bas] ; Pascale Varlet [France] ; Stephanie Puget [France] ; Christelle Dufour [France] ; Jacques Grill [France] ; Dominique Figarella-Branger [France] ; Marietta Wolter [Allemagne] ; Martin U. Schuhmann [Allemagne] ; Tarek Shalaby [Suisse] ; Michael Grotzer [Suisse] ; Timothy Van Meter [États-Unis] ; Camelia-Maria Monoranu [Allemagne] ; Jörg Felsberg [Allemagne] ; Guido Reifenberger [Allemagne] ; Matija Snuderl [États-Unis] ; Lynn Ann Forrester [États-Unis] ; Jan Koster [Pays-Bas] ; Rogier Versteeg [Pays-Bas] ; Richard Volckmann [Pays-Bas] ; Peter Van Sluis [Pays-Bas] ; Stephan Wolf [Allemagne] ; Tom Mikkelsen [États-Unis] ; Amar Gajjar [États-Unis] ; Kenneth Aldape [États-Unis] ; Andrew S. Moore [Australie] ; Michael D. Taylor [Canada] ; Chris Jones [Royaume-Uni] ; Nada Jabado [Canada] ; Matthias A. Karajannis [États-Unis] ; Roland Eils [Allemagne] ; Matthias Schlesner [Allemagne] ; Peter Lichter [Allemagne] ; Andreas Von Deimling [Allemagne] ; Stefan M. Pfister [Allemagne] ; David W. Ellison [États-Unis] ; Andrey Korshunov [Allemagne] ; Marcel Kool [Allemagne]Source :
- Cell [ 0092-8674 ] ; 2016.
Descripteurs français
- KwdFr :
- Analyse de profil d'expression de gènes, Données de séquences moléculaires, Enfant, Facteurs de transcription Forkhead (génétique), Humains, Méthylation de l'ADN, Protéines de répression (), Protéines de répression (génétique), Protéines proto-oncogènes (), Protéines proto-oncogènes (génétique), Protéines suppresseurs de tumeurs (génétique), Régulation de l'expression des gènes tumoraux, Séquence d'acides aminés, Transduction du signal, Tumeurs du système nerveux central (), Tumeurs du système nerveux central (anatomopathologie), Tumeurs du système nerveux central (diagnostic), Tumeurs du système nerveux central (génétique), Tumeurs neuroectodermiques (), Tumeurs neuroectodermiques (anatomopathologie), Tumeurs neuroectodermiques (diagnostic), Tumeurs neuroectodermiques (génétique).
- MESH :
- anatomopathologie : Tumeurs du système nerveux central, Tumeurs neuroectodermiques.
- diagnostic : Tumeurs du système nerveux central, Tumeurs neuroectodermiques.
- génétique : Facteurs de transcription Forkhead, Protéines de répression, Protéines proto-oncogènes, Protéines suppresseurs de tumeurs, Tumeurs du système nerveux central, Tumeurs neuroectodermiques.
- Analyse de profil d'expression de gènes, Données de séquences moléculaires, Enfant, Humains, Méthylation de l'ADN, Protéines de répression, Protéines proto-oncogènes, Régulation de l'expression des gènes tumoraux, Séquence d'acides aminés, Transduction du signal, Tumeurs du système nerveux central, Tumeurs neuroectodermiques.
English descriptors
- KwdEn :
- Amino Acid Sequence, Central Nervous System Neoplasms (classification), Central Nervous System Neoplasms (diagnosis), Central Nervous System Neoplasms (genetics), Central Nervous System Neoplasms (pathology), Child, DNA Methylation, Forkhead Transcription Factors (genetics), Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Molecular Sequence Data, Neuroectodermal Tumors (classification), Neuroectodermal Tumors (diagnosis), Neuroectodermal Tumors (genetics), Neuroectodermal Tumors (pathology), Proto-Oncogene Proteins (chemistry), Proto-Oncogene Proteins (genetics), Repressor Proteins (chemistry), Repressor Proteins (genetics), Signal Transduction, Tumor Suppressor Proteins (genetics).
- MESH :
- chemical , chemistry : Proto-Oncogene Proteins, Repressor Proteins.
- chemical , genetics : Forkhead Transcription Factors, Proto-Oncogene Proteins, Repressor Proteins, Tumor Suppressor Proteins.
- classification : Central Nervous System Neoplasms, Neuroectodermal Tumors.
- diagnosis : Central Nervous System Neoplasms, Neuroectodermal Tumors.
- genetics : Central Nervous System Neoplasms, Neuroectodermal Tumors.
- pathology : Central Nervous System Neoplasms, Neuroectodermal Tumors.
- Amino Acid Sequence, Child, DNA Methylation, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Molecular Sequence Data, Signal Transduction.
Abstract
Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly aggressive, poorly differentiated embryonal tumors occurring predominantly in young children but also affecting adolescents and adults. Herein we demonstrate that a significant proportion of institutionally diagnosed CNS-PNETs display molecular profiles indistinguishable from those of various other well-defined CNS tumor entities, facilitating diagnosis and appropriate therapy for patients with these tumors. From the remaining fraction of CNS-PNETs we identify four new CNS tumor entities, each associated with a recurrent genetic alteration and distinct histopathological and clinical features. These new molecular entities, designated “CNS neuroblastoma with
Url:
DOI: 10.1016/j.cell.2016.01.015
PubMed: 26919435
PubMed Central: 5139621
Affiliations:
- Allemagne, Australie, Autriche, Canada, Danemark, France, Irlande (pays), Israël, Italie, Pays-Bas, Pologne, Royaume-Uni, Russie, République tchèque, Suisse, Suède, États-Unis
- Angleterre, Angleterre de l'Est, Auvergne-Rhône-Alpes, Bade-Wurtemberg, Basse-Saxe, Bavière, Californie, Canton de Berne, Canton de Zurich, District de Basse-Franconie, District de Cologne, District de Düsseldorf, District de Fribourg-en-Brisgau, District de Haute-Bavière, District de Karlsruhe, District de Münster, District de Souabe, District fédéral central, Grand Londres, Géorgie (États-Unis), Hambourg, Hollande-Septentrionale, Latium, Michigan, Missouri (État), Ohio, Ontario, Pennsylvanie, Provence-Alpes-Côte d'Azur, Rhénanie-du-Nord-Westphalie, Rhône-Alpes, Saxe-Anhalt, Tennessee, Texas, Vienne (Autriche), Virginie, État de New York, Île-de-France
- Amsterdam, Augsbourg, Berne, Bonn, Cambridge, Düsseldorf, Fribourg-en-Brisgau, Göttingen, Hambourg, Heidelberg, Londres, Lyon, Magdebourg, Marseille, Moscou, Munich, Münster, Paris, Rome, Toronto, Vienne (Autriche), Wurtzbourg, Zurich
- Université Louis-et-Maximilien de Munich, Université d'Amsterdam, Université de Cambridge, Université de Toronto
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Le document en format XML
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<author><name sortKey="Leis, Irina" sort="Leis, Irina" uniqKey="Leis I" first="Irina" last="Leis">Irina Leis</name>
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<author><name sortKey="Ryzhova, Marina" sort="Ryzhova, Marina" uniqKey="Ryzhova M" first="Marina" last="Ryzhova">Marina Ryzhova</name>
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<author><name sortKey="Koelsche, Christian" sort="Koelsche, Christian" uniqKey="Koelsche C" first="Christian" last="Koelsche">Christian Koelsche</name>
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<author><name sortKey="Pfaff, Elke" sort="Pfaff, Elke" uniqKey="Pfaff E" first="Elke" last="Pfaff">Elke Pfaff</name>
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<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
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<author><name sortKey="Allen, Sariah J" sort="Allen, Sariah J" uniqKey="Allen S" first="Sariah J." last="Allen">Sariah J. Allen</name>
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<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105-3678</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Balasubramanian, Gnanaprakash" sort="Balasubramanian, Gnanaprakash" uniqKey="Balasubramanian G" first="Gnanaprakash" last="Balasubramanian">Gnanaprakash Balasubramanian</name>
<affiliation wicri:level="3"><nlm:aff id="A10"> Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), National Center for Tumor Diseases (NCT), and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
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<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
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<author><name sortKey="Worst, Barbara C" sort="Worst, Barbara C" uniqKey="Worst B" first="Barbara C." last="Worst">Barbara C. Worst</name>
<affiliation wicri:level="3"><nlm:aff id="A1"> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A2"> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pajtler, Kristian W" sort="Pajtler, Kristian W" uniqKey="Pajtler K" first="Kristian W." last="Pajtler">Kristian W. Pajtler</name>
<affiliation wicri:level="3"><nlm:aff id="A1"> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brabetz, Sebastian" sort="Brabetz, Sebastian" uniqKey="Brabetz S" first="Sebastian" last="Brabetz">Sebastian Brabetz</name>
<affiliation wicri:level="3"><nlm:aff id="A1"> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Johann, Pascal D" sort="Johann, Pascal D" uniqKey="Johann P" first="Pascal D." last="Johann">Pascal D. Johann</name>
<affiliation wicri:level="3"><nlm:aff id="A1"> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A2"> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sahm, Felix" sort="Sahm, Felix" uniqKey="Sahm F" first="Felix" last="Sahm">Felix Sahm</name>
<affiliation wicri:level="3"><nlm:aff id="A6"> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation><nlm:aff id="A7"> Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg.</nlm:aff>
<wicri:noCountry code="subfield">69120 Heidelberg.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Reimand, Juri" sort="Reimand, Juri" uniqKey="Reimand J" first="Jüri" last="Reimand">Jüri Reimand</name>
<affiliation wicri:level="1"><nlm:aff id="A11"> Ontario Institute for Cancer Research, M5G 0A3, Toronto, ON M5G 1L7, Canada.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Canada</country>
<wicri:regionArea> Ontario Institute for Cancer Research, M5G 0A3, Toronto, ON M5G 1L7</wicri:regionArea>
<wicri:noRegion>ON M5G 1L7</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A12"> Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Canada</country>
<wicri:regionArea> Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mackay, Alan" sort="Mackay, Alan" uniqKey="Mackay A" first="Alan" last="Mackay">Alan Mackay</name>
<affiliation wicri:level="3"><nlm:aff id="A13"> Division of Molecular Pathology, The Institute of Cancer Research, SW7 3RP, London, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea> Division of Molecular Pathology, The Institute of Cancer Research, SW7 3RP, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Carvalho, Diana M" sort="Carvalho, Diana M" uniqKey="Carvalho D" first="Diana M." last="Carvalho">Diana M. Carvalho</name>
<affiliation wicri:level="3"><nlm:aff id="A13"> Division of Molecular Pathology, The Institute of Cancer Research, SW7 3RP, London, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea> Division of Molecular Pathology, The Institute of Cancer Research, SW7 3RP, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Remke, Marc" sort="Remke, Marc" uniqKey="Remke M" first="Marc" last="Remke">Marc Remke</name>
<affiliation wicri:level="4"><nlm:aff id="A14"> Program in Developmental and Stem Cell Biology, Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Toronto, ON M4N 1X8, Canada.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Canada</country>
<wicri:regionArea> Program in Developmental and Stem Cell Biology, Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Toronto, ON M4N 1X8</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Phillips, Joanna J" sort="Phillips, Joanna J" uniqKey="Phillips J" first="Joanna J." last="Phillips">Joanna J. Phillips</name>
<affiliation wicri:level="2"><nlm:aff id="A15"> Brain Tumor Research Center, University of California, San Francisco, CA 94158-9001, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Brain Tumor Research Center, University of California, San Francisco, CA 94158-9001</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A16"> Neuropathology, Department of Pathology, University of California, San Francisco, CA 94143-0102, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Neuropathology, Department of Pathology, University of California, San Francisco, CA 94143-0102</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A17"> Department of Neurological Surgery, University of California, San Francisco, CA 94143-0112, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurological Surgery, University of California, San Francisco, CA 94143-0112</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Perry, Arie" sort="Perry, Arie" uniqKey="Perry A" first="Arie" last="Perry">Arie Perry</name>
<affiliation wicri:level="2"><nlm:aff id="A15"> Brain Tumor Research Center, University of California, San Francisco, CA 94158-9001, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Brain Tumor Research Center, University of California, San Francisco, CA 94158-9001</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A16"> Neuropathology, Department of Pathology, University of California, San Francisco, CA 94143-0102, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Neuropathology, Department of Pathology, University of California, San Francisco, CA 94143-0102</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A17"> Department of Neurological Surgery, University of California, San Francisco, CA 94143-0112, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurological Surgery, University of California, San Francisco, CA 94143-0112</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cowdrey, Cynthia" sort="Cowdrey, Cynthia" uniqKey="Cowdrey C" first="Cynthia" last="Cowdrey">Cynthia Cowdrey</name>
<affiliation wicri:level="2"><nlm:aff id="A15"> Brain Tumor Research Center, University of California, San Francisco, CA 94158-9001, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Brain Tumor Research Center, University of California, San Francisco, CA 94158-9001</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Drissi, Rachid" sort="Drissi, Rachid" uniqKey="Drissi R" first="Rachid" last="Drissi">Rachid Drissi</name>
<affiliation wicri:level="2"><nlm:aff id="A18"> Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fouladi, Maryam" sort="Fouladi, Maryam" uniqKey="Fouladi M" first="Maryam" last="Fouladi">Maryam Fouladi</name>
<affiliation wicri:level="2"><nlm:aff id="A18"> Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Giangaspero, Felice" sort="Giangaspero, Felice" uniqKey="Giangaspero F" first="Felice" last="Giangaspero">Felice Giangaspero</name>
<affiliation wicri:level="1"><nlm:aff id="A19"> Department of Radiological, Oncological and Anatomic-Pathological Sciences, Sapienza University of Rome, 00185 Rome, Italy.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Italie</country>
<wicri:regionArea> Department of Radiological, Oncological and Anatomic-Pathological Sciences, Sapienza University of Rome, 00185 Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A20"> IRCCS Neuromed, 86077 Pozzilli, Molise, Italy.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Italie</country>
<wicri:regionArea> IRCCS Neuromed, 86077 Pozzilli, Molise</wicri:regionArea>
<wicri:noRegion>Molise</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lastowska, Maria" sort="Lastowska, Maria" uniqKey="Lastowska M" first="Maria" last="Łastowska">Maria Łastowska</name>
<affiliation wicri:level="1"><nlm:aff id="A21"> Department of Pathology, Children's Memorial Health Institute, 04-730 Warsaw, Poland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pologne</country>
<wicri:regionArea> Department of Pathology, Children's Memorial Health Institute, 04-730 Warsaw</wicri:regionArea>
<wicri:noRegion>04-730 Warsaw</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Grajkowska, Wieslawa" sort="Grajkowska, Wieslawa" uniqKey="Grajkowska W" first="Wiesława" last="Grajkowska">Wiesława Grajkowska</name>
<affiliation wicri:level="1"><nlm:aff id="A21"> Department of Pathology, Children's Memorial Health Institute, 04-730 Warsaw, Poland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pologne</country>
<wicri:regionArea> Department of Pathology, Children's Memorial Health Institute, 04-730 Warsaw</wicri:regionArea>
<wicri:noRegion>04-730 Warsaw</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Scheurlen, Wolfram" sort="Scheurlen, Wolfram" uniqKey="Scheurlen W" first="Wolfram" last="Scheurlen">Wolfram Scheurlen</name>
<affiliation wicri:level="1"><nlm:aff id="A22"> Cnopf'sche Kinderklinik, Nürnberg Children's Hospital, 90419 Nürnberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Cnopf'sche Kinderklinik, Nürnberg Children's Hospital, 90419 Nürnberg</wicri:regionArea>
<wicri:noRegion>90419 Nürnberg</wicri:noRegion>
<wicri:noRegion>90419 Nürnberg</wicri:noRegion>
<wicri:noRegion>90419 Nürnberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pietsch, Torsten" sort="Pietsch, Torsten" uniqKey="Pietsch T" first="Torsten" last="Pietsch">Torsten Pietsch</name>
<affiliation wicri:level="1"><nlm:aff id="A23"> Department of Neuropathology, University of Bonn Medical School, 53105 Bonn, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, University of Bonn Medical School, 53105 Bonn</wicri:regionArea>
<wicri:noRegion>53105 Bonn</wicri:noRegion>
<placeName><settlement type="city">Bonn</settlement>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hagel, Christian" sort="Hagel, Christian" uniqKey="Hagel C" first="Christian" last="Hagel">Christian Hagel</name>
<affiliation wicri:level="1"><nlm:aff id="A24"> Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg</wicri:regionArea>
<wicri:noRegion>20246 Hamburg</wicri:noRegion>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gojo, Johannes" sort="Gojo, Johannes" uniqKey="Gojo J" first="Johannes" last="Gojo">Johannes Gojo</name>
<affiliation wicri:level="3"><nlm:aff id="A25"> Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, 1090 Vienna, Austria.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Autriche</country>
<wicri:regionArea> Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, 1090 Vienna</wicri:regionArea>
<placeName><region type="land" nuts="2">Vienne (Autriche)</region>
<settlement type="city">Vienne (Autriche)</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A26"> Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Autriche</country>
<wicri:regionArea> Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna</wicri:regionArea>
<placeName><region type="land" nuts="2">Vienne (Autriche)</region>
<settlement type="city">Vienne (Autriche)</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lotsch, Daniela" sort="Lotsch, Daniela" uniqKey="Lotsch D" first="Daniela" last="Lötsch">Daniela Lötsch</name>
<affiliation wicri:level="3"><nlm:aff id="A26"> Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Autriche</country>
<wicri:regionArea> Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna</wicri:regionArea>
<placeName><region type="land" nuts="2">Vienne (Autriche)</region>
<settlement type="city">Vienne (Autriche)</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Berger, Walter" sort="Berger, Walter" uniqKey="Berger W" first="Walter" last="Berger">Walter Berger</name>
<affiliation wicri:level="3"><nlm:aff id="A26"> Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Autriche</country>
<wicri:regionArea> Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna</wicri:regionArea>
<placeName><region type="land" nuts="2">Vienne (Autriche)</region>
<settlement type="city">Vienne (Autriche)</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Slavc, Irene" sort="Slavc, Irene" uniqKey="Slavc I" first="Irene" last="Slavc">Irene Slavc</name>
<affiliation wicri:level="3"><nlm:aff id="A25"> Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, 1090 Vienna, Austria.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Autriche</country>
<wicri:regionArea> Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, 1090 Vienna</wicri:regionArea>
<placeName><region type="land" nuts="2">Vienne (Autriche)</region>
<settlement type="city">Vienne (Autriche)</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Haberler, Christine" sort="Haberler, Christine" uniqKey="Haberler C" first="Christine" last="Haberler">Christine Haberler</name>
<affiliation wicri:level="3"><nlm:aff id="A27"> Institute of Neurology, Medical University of Vienna, 1097 Vienna, Austria.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Autriche</country>
<wicri:regionArea> Institute of Neurology, Medical University of Vienna, 1097 Vienna</wicri:regionArea>
<placeName><region type="land" nuts="2">Vienne (Autriche)</region>
<settlement type="city">Vienne (Autriche)</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jouvet, Anne" sort="Jouvet, Anne" uniqKey="Jouvet A" first="Anne" last="Jouvet">Anne Jouvet</name>
<affiliation wicri:level="1"><nlm:aff id="A28"> Neuro-Oncology and Neuro-Inflammation Team, Inserm U1028, CNRS UMR 5292, University Lyon-1, Neuroscience Center, 69000 Lyon, France, and Centre de Pathologie et de Neuropathologie Est, Hospices Civils de Lyon, 69003 Lyon, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea> Neuro-Oncology and Neuro-Inflammation Team, Inserm U1028, CNRS UMR 5292, University Lyon-1, Neuroscience Center, 69000 Lyon, France, and Centre de Pathologie et de Neuropathologie Est, Hospices Civils de Lyon, 69003 Lyon</wicri:regionArea>
<wicri:noRegion>69003 Lyon</wicri:noRegion>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Holm, Stefan" sort="Holm, Stefan" uniqKey="Holm S" first="Stefan" last="Holm">Stefan Holm</name>
<affiliation wicri:level="1"><nlm:aff id="A29"> Department of Women's and Children's Health (KBH), Karolinska Institutet, SE-171 77 Stockholm, Sweden.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Suède</country>
<wicri:regionArea> Department of Women's and Children's Health (KBH), Karolinska Institutet, SE-171 77 Stockholm</wicri:regionArea>
<wicri:noRegion>SE-171 77 Stockholm</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hofer, Silvia" sort="Hofer, Silvia" uniqKey="Hofer S" first="Silvia" last="Hofer">Silvia Hofer</name>
<affiliation wicri:level="1"><nlm:aff id="A30"> Department of Oncology, Luzerner Kantonsspital, 6000 Luzern 16, Luzern, Switzerland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Suisse</country>
<wicri:regionArea> Department of Oncology, Luzerner Kantonsspital, 6000 Luzern 16, Luzern</wicri:regionArea>
<wicri:noRegion>Luzern</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Prinz, Marco" sort="Prinz, Marco" uniqKey="Prinz M" first="Marco" last="Prinz">Marco Prinz</name>
<affiliation wicri:level="3"><nlm:aff id="A31"> Institute of Neuropathology, University of Freiburg, Germany & BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79106 Freiburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Institute of Neuropathology, University of Freiburg, Germany & BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79106 Freiburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Fribourg-en-Brisgau</region>
<settlement type="city">Fribourg-en-Brisgau</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Keohane, Catherine" sort="Keohane, Catherine" uniqKey="Keohane C" first="Catherine" last="Keohane">Catherine Keohane</name>
<affiliation wicri:level="1"><nlm:aff id="A32"> Department of Pathology, University College Cork and Cork University Hospital Wilton, Cork, Ireland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Irlande (pays)</country>
<wicri:regionArea> Department of Pathology, University College Cork and Cork University Hospital Wilton, Cork</wicri:regionArea>
<wicri:noRegion>Cork</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fried, Iris" sort="Fried, Iris" uniqKey="Fried I" first="Iris" last="Fried">Iris Fried</name>
<affiliation wicri:level="1"><nlm:aff id="A33"> Department of Pediatric Hematology and Oncology, Hadassah Medical Center, Jerusalem, Israel.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Israël</country>
<wicri:regionArea> Department of Pediatric Hematology and Oncology, Hadassah Medical Center, Jerusalem</wicri:regionArea>
<wicri:noRegion>Jerusalem</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mawrin, Christian" sort="Mawrin, Christian" uniqKey="Mawrin C" first="Christian" last="Mawrin">Christian Mawrin</name>
<affiliation wicri:level="3"><nlm:aff id="A34"> Institute of Neuropathology, University Hospital, Otto-von-Guericke University, 39120 Magdeburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Institute of Neuropathology, University Hospital, Otto-von-Guericke University, 39120 Magdeburg</wicri:regionArea>
<placeName><region type="land" nuts="2">Saxe-Anhalt</region>
<settlement type="city">Magdebourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Scheie, David" sort="Scheie, David" uniqKey="Scheie D" first="David" last="Scheie">David Scheie</name>
<affiliation wicri:level="1"><nlm:aff id="A35"> Department of Pathology, Copenhagen University Hospital, 2100 København Ø, Denmark.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Danemark</country>
<wicri:regionArea> Department of Pathology, Copenhagen University Hospital, 2100 København Ø</wicri:regionArea>
<wicri:noRegion>2100 København Ø</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mobley, Bret C" sort="Mobley, Bret C" uniqKey="Mobley B" first="Bret C." last="Mobley">Bret C. Mobley</name>
<affiliation wicri:level="2"><nlm:aff id="A36"> Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schniederjan, Matthew J" sort="Schniederjan, Matthew J" uniqKey="Schniederjan M" first="Matthew J." last="Schniederjan">Matthew J. Schniederjan</name>
<affiliation wicri:level="2"><nlm:aff id="A37"> Department of Pathology and Laboratory Administration, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Pathology and Laboratory Administration, Children's Healthcare of Atlanta, Atlanta, GA 30322</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Santi, Mariarita" sort="Santi, Mariarita" uniqKey="Santi M" first="Mariarita" last="Santi">Mariarita Santi</name>
<affiliation wicri:level="2"><nlm:aff id="A38"> Department of Pathology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Pathology, Children's Hospital of Philadelphia, Philadelphia, PA 19104</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Buccoliero, Anna M" sort="Buccoliero, Anna M" uniqKey="Buccoliero A" first="Anna M." last="Buccoliero">Anna M. Buccoliero</name>
<affiliation wicri:level="1"><nlm:aff id="A39"> Pathology Unit, Anna Meyer Children's University Hospital, 50141 Florence, Italy.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Italie</country>
<wicri:regionArea> Pathology Unit, Anna Meyer Children's University Hospital, 50141 Florence</wicri:regionArea>
<wicri:noRegion>50141 Florence</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dahiya, Sonika" sort="Dahiya, Sonika" uniqKey="Dahiya S" first="Sonika" last="Dahiya">Sonika Dahiya</name>
<affiliation wicri:level="2"><nlm:aff id="A40"> Department of Pathology and Immunology, Washington University, St. Louis, MO 63110, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Pathology and Immunology, Washington University, St. Louis, MO 63110</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kramm, Christof M" sort="Kramm, Christof M" uniqKey="Kramm C" first="Christof M." last="Kramm">Christof M. Kramm</name>
<affiliation wicri:level="3"><nlm:aff id="A41"> Division of Pediatric Hematology and Oncology, Department of Child and Adolescent Health, University Medical Center Göttingen, 37075 Göttingen, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Hematology and Oncology, Department of Child and Adolescent Health, University Medical Center Göttingen, 37075 Göttingen</wicri:regionArea>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Göttingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Von Bueren, Andre O" sort="Von Bueren, Andre O" uniqKey="Von Bueren A" first="André O." last="Von Bueren">André O. Von Bueren</name>
<affiliation wicri:level="3"><nlm:aff id="A41"> Division of Pediatric Hematology and Oncology, Department of Child and Adolescent Health, University Medical Center Göttingen, 37075 Göttingen, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Hematology and Oncology, Department of Child and Adolescent Health, University Medical Center Göttingen, 37075 Göttingen</wicri:regionArea>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Göttingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Von Hoff, Katja" sort="Von Hoff, Katja" uniqKey="Von Hoff K" first="Katja" last="Von Hoff">Katja Von Hoff</name>
<affiliation wicri:level="1"><nlm:aff id="A42"> Department of Pediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg</wicri:regionArea>
<wicri:noRegion>20246 Hamburg</wicri:noRegion>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rutkowski, Stefan" sort="Rutkowski, Stefan" uniqKey="Rutkowski S" first="Stefan" last="Rutkowski">Stefan Rutkowski</name>
<affiliation wicri:level="1"><nlm:aff id="A42"> Department of Pediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg</wicri:regionArea>
<wicri:noRegion>20246 Hamburg</wicri:noRegion>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Herold Mende, Christel" sort="Herold Mende, Christel" uniqKey="Herold Mende C" first="Christel" last="Herold-Mende">Christel Herold-Mende</name>
<affiliation wicri:level="3"><nlm:aff id="A43"> Department of Neurosurgery, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neurosurgery, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fruhwald, Michael C" sort="Fruhwald, Michael C" uniqKey="Fruhwald M" first="Michael C." last="Frühwald">Michael C. Frühwald</name>
<affiliation wicri:level="3"><nlm:aff id="A44"> Pediatric Hospital, Klinikum Augsburg, 86156 Augsburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Pediatric Hospital, Klinikum Augsburg, 86156 Augsburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Souabe</region>
<settlement type="city">Augsbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Milde, Till" sort="Milde, Till" uniqKey="Milde T" first="Till" last="Milde">Till Milde</name>
<affiliation wicri:level="3"><nlm:aff id="A2"> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A45"> Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hasselblatt, Martin" sort="Hasselblatt, Martin" uniqKey="Hasselblatt M" first="Martin" last="Hasselblatt">Martin Hasselblatt</name>
<affiliation wicri:level="3"><nlm:aff id="A46"> Institute of Neuropathology, University Hospital Münster, 48149 Münster, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Institute of Neuropathology, University Hospital Münster, 48149 Münster</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Münster</region>
<settlement type="city">Münster</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wesseling, Pieter" sort="Wesseling, Pieter" uniqKey="Wesseling P" first="Pieter" last="Wesseling">Pieter Wesseling</name>
<affiliation wicri:level="1"><nlm:aff id="A47"> Department of Pathology, VU University Medical Center Amsterdam, 1008 MB Amsterdam, The Netherlands.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea> Department of Pathology, VU University Medical Center Amsterdam, 1008 MB Amsterdam</wicri:regionArea>
<wicri:noRegion>1008 MB Amsterdam</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A48"> Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, 6525 GA, The Netherlands.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea> Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, 6525 GA</wicri:regionArea>
<wicri:noRegion>6525 GA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ro Ler, Jochen" sort="Ro Ler, Jochen" uniqKey="Ro Ler J" first="Jochen" last="Rö Ler">Jochen Rö Ler</name>
<affiliation wicri:level="3"><nlm:aff id="A49"> Department of Pediatric Hematology/Oncology, Center of Pediatrics and Adolescent Medicine, University Medical Center Freiburg, 79106 Freiburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Hematology/Oncology, Center of Pediatrics and Adolescent Medicine, University Medical Center Freiburg, 79106 Freiburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Fribourg-en-Brisgau</region>
<settlement type="city">Fribourg-en-Brisgau</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schuller, Ulrich" sort="Schuller, Ulrich" uniqKey="Schuller U" first="Ulrich" last="Schüller">Ulrich Schüller</name>
<affiliation wicri:level="4"><nlm:aff id="A50"> Department of Neuropathology, Ludwig-Maximilians-University, and German Cancer Consortium (DKTK) partner site Munich, 81377 Munich, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Ludwig-Maximilians-University, and German Cancer Consortium (DKTK) partner site Munich, 81377 Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
</author>
<author><name sortKey="Ebinger, Martin" sort="Ebinger, Martin" uniqKey="Ebinger M" first="Martin" last="Ebinger">Martin Ebinger</name>
<affiliation wicri:level="1"><nlm:aff id="A51"> Department of Hematology and Oncology, Children's University Hospital Tübingen, and German Cancer Consortium (DKTK) partner site Tübingen, 72076 Tübingen, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Hematology and Oncology, Children's University Hospital Tübingen, and German Cancer Consortium (DKTK) partner site Tübingen, 72076 Tübingen</wicri:regionArea>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schittenhelm, Jens" sort="Schittenhelm, Jens" uniqKey="Schittenhelm J" first="Jens" last="Schittenhelm">Jens Schittenhelm</name>
<affiliation wicri:level="1"><nlm:aff id="A52"> Department of Neuropathology, Institute of Pathology and Neuropathology, University of Tübingen, and German Cancer Consortium (DKTK) partner site Tübingen, 72076 Tübingen, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Institute of Pathology and Neuropathology, University of Tübingen, and German Cancer Consortium (DKTK) partner site Tübingen, 72076 Tübingen</wicri:regionArea>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Frank, Stephan" sort="Frank, Stephan" uniqKey="Frank S" first="Stephan" last="Frank">Stephan Frank</name>
<affiliation wicri:level="1"><nlm:aff id="A53"> Department of Neuropathology, Institute of Pathology, Basel University Hospital, 4031 Basel, Switzerland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Suisse</country>
<wicri:regionArea> Department of Neuropathology, Institute of Pathology, Basel University Hospital, 4031 Basel</wicri:regionArea>
<wicri:noRegion>4031 Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Grobholz, Rainer" sort="Grobholz, Rainer" uniqKey="Grobholz R" first="Rainer" last="Grobholz">Rainer Grobholz</name>
<affiliation wicri:level="1"><nlm:aff id="A54"> Department of Pathology, Medical Center Aarau, 5001 Aarau, Switzerland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Suisse</country>
<wicri:regionArea> Department of Pathology, Medical Center Aarau, 5001 Aarau</wicri:regionArea>
<wicri:noRegion>5001 Aarau</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vajtai, Istvan" sort="Vajtai, Istvan" uniqKey="Vajtai I" first="Istvan" last="Vajtai">Istvan Vajtai</name>
<affiliation wicri:level="1"><nlm:aff id="A55"> Department of Pathology, University Hospital Bern, 3010 Bern, Switzerland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Suisse</country>
<wicri:regionArea> Department of Pathology, University Hospital Bern, 3010 Bern</wicri:regionArea>
<placeName><settlement type="city">Berne</settlement>
<region type="région" nuts="3">Canton de Berne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hans, Volkmar" sort="Hans, Volkmar" uniqKey="Hans V" first="Volkmar" last="Hans">Volkmar Hans</name>
<affiliation wicri:level="1"><nlm:aff id="A56"> Department of Neuropathology, Medical Center Bielefeld, 33617 Bielefeld, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Medical Center Bielefeld, 33617 Bielefeld</wicri:regionArea>
<wicri:noRegion>33617 Bielefeld</wicri:noRegion>
<wicri:noRegion>33617 Bielefeld</wicri:noRegion>
<wicri:noRegion>33617 Bielefeld</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schneppenheim, Reinhard" sort="Schneppenheim, Reinhard" uniqKey="Schneppenheim R" first="Reinhard" last="Schneppenheim">Reinhard Schneppenheim</name>
<affiliation wicri:level="1"><nlm:aff id="A42"> Department of Pediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg</wicri:regionArea>
<wicri:noRegion>20246 Hamburg</wicri:noRegion>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zitterbart, Karel" sort="Zitterbart, Karel" uniqKey="Zitterbart K" first="Karel" last="Zitterbart">Karel Zitterbart</name>
<affiliation wicri:level="1"><nlm:aff id="A57"> Department of Pediatric Oncology, University Hospital Brno and Masaryk University, Faculty of Medicine, 613 00 Brno, Czech Republic.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République tchèque</country>
<wicri:regionArea> Department of Pediatric Oncology, University Hospital Brno and Masaryk University, Faculty of Medicine, 613 00 Brno</wicri:regionArea>
<wicri:noRegion>613 00 Brno</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Collins, V Peter" sort="Collins, V Peter" uniqKey="Collins V" first="V. Peter" last="Collins">V. Peter Collins</name>
<affiliation wicri:level="4"><nlm:aff id="A58"> Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea> Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, CB2 0QQ</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Aronica, Eleonora" sort="Aronica, Eleonora" uniqKey="Aronica E" first="Eleonora" last="Aronica">Eleonora Aronica</name>
<affiliation wicri:level="4"><nlm:aff id="A59"> Department of Neuropathology, AMC, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea> Department of Neuropathology, AMC, University of Amsterdam, Amsterdam, 1105 AZ</wicri:regionArea>
<orgName type="university">Université d'Amsterdam</orgName>
<placeName><settlement type="city">Amsterdam</settlement>
<region>Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Varlet, Pascale" sort="Varlet, Pascale" uniqKey="Varlet P" first="Pascale" last="Varlet">Pascale Varlet</name>
<affiliation wicri:level="3"><nlm:aff id="A60"> Department of Neuropathology, Hôpital Sainte-Anne, 75674, Paris, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea> Department of Neuropathology, Hôpital Sainte-Anne, 75674, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Puget, Stephanie" sort="Puget, Stephanie" uniqKey="Puget S" first="Stephanie" last="Puget">Stephanie Puget</name>
<affiliation wicri:level="3"><nlm:aff id="A61"> Pediatric Neurosurgery Department, Necker Enfants Malades Hospital, 75015, Paris, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea> Pediatric Neurosurgery Department, Necker Enfants Malades Hospital, 75015, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dufour, Christelle" sort="Dufour, Christelle" uniqKey="Dufour C" first="Christelle" last="Dufour">Christelle Dufour</name>
<affiliation wicri:level="1"><nlm:aff id="A62"> Brain Tumor Program, Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Institute, University Paris Sud, 94805, Villejuif, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea> Brain Tumor Program, Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Institute, University Paris Sud, 94805, Villejuif</wicri:regionArea>
<wicri:noRegion>94805, Villejuif</wicri:noRegion>
<wicri:noRegion>94805, Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Grill, Jacques" sort="Grill, Jacques" uniqKey="Grill J" first="Jacques" last="Grill">Jacques Grill</name>
<affiliation wicri:level="1"><nlm:aff id="A62"> Brain Tumor Program, Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Institute, University Paris Sud, 94805, Villejuif, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea> Brain Tumor Program, Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Institute, University Paris Sud, 94805, Villejuif</wicri:regionArea>
<wicri:noRegion>94805, Villejuif</wicri:noRegion>
<wicri:noRegion>94805, Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Figarella Branger, Dominique" sort="Figarella Branger, Dominique" uniqKey="Figarella Branger D" first="Dominique" last="Figarella-Branger">Dominique Figarella-Branger</name>
<affiliation wicri:level="1"><nlm:aff id="A63"> Department of Pathology and Neuropathology, la Timone Hospital, AP-HM and UMR911 CR02, Aix-Marseille University, 13385 Marseille, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea> Department of Pathology and Neuropathology, la Timone Hospital, AP-HM and UMR911 CR02, Aix-Marseille University, 13385 Marseille</wicri:regionArea>
<wicri:noRegion>13385 Marseille</wicri:noRegion>
<placeName><settlement type="city">Marseille</settlement>
<region type="région" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wolter, Marietta" sort="Wolter, Marietta" uniqKey="Wolter M" first="Marietta" last="Wolter">Marietta Wolter</name>
<affiliation wicri:level="3"><nlm:aff id="A64"> Department of Neuropathology, Heinrich-Heine-University, and German Cancer Consortium (DKTK) partner site Essen/Düsseldorf, 40225 Düsseldorf, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Heinrich-Heine-University, and German Cancer Consortium (DKTK) partner site Essen/Düsseldorf, 40225 Düsseldorf</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schuhmann, Martin U" sort="Schuhmann, Martin U" uniqKey="Schuhmann M" first="Martin U." last="Schuhmann">Martin U. Schuhmann</name>
<affiliation wicri:level="1"><nlm:aff id="A65"> Department of Neurosurgery, Section of Pediatric Neurosurgery, University Hospital Tübingen, and German Cancer Consortium (DKTK) partner site Tübingen, 72076 Tübingen, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neurosurgery, Section of Pediatric Neurosurgery, University Hospital Tübingen, and German Cancer Consortium (DKTK) partner site Tübingen, 72076 Tübingen</wicri:regionArea>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shalaby, Tarek" sort="Shalaby, Tarek" uniqKey="Shalaby T" first="Tarek" last="Shalaby">Tarek Shalaby</name>
<affiliation wicri:level="1"><nlm:aff id="A66"> Neuro-Oncology Program, Division of Oncology, University Children's Hospital Zurich, 8032 Zürich, Switzerland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Suisse</country>
<wicri:regionArea> Neuro-Oncology Program, Division of Oncology, University Children's Hospital Zurich, 8032 Zürich</wicri:regionArea>
<placeName><settlement type="city">Zurich</settlement>
<region nuts="3" type="region">Canton de Zurich</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grotzer, Michael" sort="Grotzer, Michael" uniqKey="Grotzer M" first="Michael" last="Grotzer">Michael Grotzer</name>
<affiliation wicri:level="1"><nlm:aff id="A66"> Neuro-Oncology Program, Division of Oncology, University Children's Hospital Zurich, 8032 Zürich, Switzerland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Suisse</country>
<wicri:regionArea> Neuro-Oncology Program, Division of Oncology, University Children's Hospital Zurich, 8032 Zürich</wicri:regionArea>
<placeName><settlement type="city">Zurich</settlement>
<region nuts="3" type="region">Canton de Zurich</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Meter, Timothy" sort="Van Meter, Timothy" uniqKey="Van Meter T" first="Timothy" last="Van Meter">Timothy Van Meter</name>
<affiliation wicri:level="2"><nlm:aff id="A67"> Virginia Commonwealth University, Richmond, VA 23298, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Virginia Commonwealth University, Richmond, VA 23298</wicri:regionArea>
<placeName><region type="state">Virginie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Monoranu, Camelia Maria" sort="Monoranu, Camelia Maria" uniqKey="Monoranu C" first="Camelia-Maria" last="Monoranu">Camelia-Maria Monoranu</name>
<affiliation wicri:level="3"><nlm:aff id="A68"> Department of Neuropathology, Institute of Pathology, University of Würzburg, and Comprehensive Cancer Center (CCC) Mainfranken, University and University Hospital, 97080 Würzburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Institute of Pathology, University of Würzburg, and Comprehensive Cancer Center (CCC) Mainfranken, University and University Hospital, 97080 Würzburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Basse-Franconie</region>
<settlement type="city">Wurtzbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Felsberg, Jorg" sort="Felsberg, Jorg" uniqKey="Felsberg J" first="Jörg" last="Felsberg">Jörg Felsberg</name>
<affiliation wicri:level="3"><nlm:aff id="A64"> Department of Neuropathology, Heinrich-Heine-University, and German Cancer Consortium (DKTK) partner site Essen/Düsseldorf, 40225 Düsseldorf, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Heinrich-Heine-University, and German Cancer Consortium (DKTK) partner site Essen/Düsseldorf, 40225 Düsseldorf</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Reifenberger, Guido" sort="Reifenberger, Guido" uniqKey="Reifenberger G" first="Guido" last="Reifenberger">Guido Reifenberger</name>
<affiliation wicri:level="3"><nlm:aff id="A64"> Department of Neuropathology, Heinrich-Heine-University, and German Cancer Consortium (DKTK) partner site Essen/Düsseldorf, 40225 Düsseldorf, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Heinrich-Heine-University, and German Cancer Consortium (DKTK) partner site Essen/Düsseldorf, 40225 Düsseldorf</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Snuderl, Matija" sort="Snuderl, Matija" uniqKey="Snuderl M" first="Matija" last="Snuderl">Matija Snuderl</name>
<affiliation wicri:level="2"><nlm:aff id="A69"> Department of Pathology, Division of Neuropathology, NYU Langone Medical Center, New York, NY 10016, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Pathology, Division of Neuropathology, NYU Langone Medical Center, New York, NY 10016</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Forrester, Lynn Ann" sort="Forrester, Lynn Ann" uniqKey="Forrester L" first="Lynn Ann" last="Forrester">Lynn Ann Forrester</name>
<affiliation wicri:level="2"><nlm:aff id="A70"> NYU School of Medicine, New York, NY 10016, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> NYU School of Medicine, New York, NY 10016</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Koster, Jan" sort="Koster, Jan" uniqKey="Koster J" first="Jan" last="Koster">Jan Koster</name>
<affiliation wicri:level="4"><nlm:aff id="A71"> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ</wicri:regionArea>
<orgName type="university">Université d'Amsterdam</orgName>
<placeName><settlement type="city">Amsterdam</settlement>
<region>Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Versteeg, Rogier" sort="Versteeg, Rogier" uniqKey="Versteeg R" first="Rogier" last="Versteeg">Rogier Versteeg</name>
<affiliation wicri:level="4"><nlm:aff id="A71"> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ</wicri:regionArea>
<orgName type="university">Université d'Amsterdam</orgName>
<placeName><settlement type="city">Amsterdam</settlement>
<region>Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Volckmann, Richard" sort="Volckmann, Richard" uniqKey="Volckmann R" first="Richard" last="Volckmann">Richard Volckmann</name>
<affiliation wicri:level="4"><nlm:aff id="A71"> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ</wicri:regionArea>
<orgName type="university">Université d'Amsterdam</orgName>
<placeName><settlement type="city">Amsterdam</settlement>
<region>Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Sluis, Peter" sort="Van Sluis, Peter" uniqKey="Van Sluis P" first="Peter" last="Van Sluis">Peter Van Sluis</name>
<affiliation wicri:level="4"><nlm:aff id="A71"> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ</wicri:regionArea>
<orgName type="university">Université d'Amsterdam</orgName>
<placeName><settlement type="city">Amsterdam</settlement>
<region>Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wolf, Stephan" sort="Wolf, Stephan" uniqKey="Wolf S" first="Stephan" last="Wolf">Stephan Wolf</name>
<affiliation wicri:level="3"><nlm:aff id="A72"> Genomics and Proteomics Core Facility, High Throughput Sequencing Unit, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Genomics and Proteomics Core Facility, High Throughput Sequencing Unit, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mikkelsen, Tom" sort="Mikkelsen, Tom" uniqKey="Mikkelsen T" first="Tom" last="Mikkelsen">Tom Mikkelsen</name>
<affiliation wicri:level="2"><nlm:aff id="A73"> Departments of Neurology and Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Departments of Neurology and Neurosurgery, Henry Ford Hospital, Detroit, MI 48202</wicri:regionArea>
<placeName><region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gajjar, Amar" sort="Gajjar, Amar" uniqKey="Gajjar A" first="Amar" last="Gajjar">Amar Gajjar</name>
<affiliation wicri:level="2"><nlm:aff id="A74"> Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Aldape, Kenneth" sort="Aldape, Kenneth" uniqKey="Aldape K" first="Kenneth" last="Aldape">Kenneth Aldape</name>
<affiliation wicri:level="2"><nlm:aff id="A75"> Department of Neuro-Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neuro-Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moore, Andrew S" sort="Moore, Andrew S" uniqKey="Moore A" first="Andrew S." last="Moore">Andrew S. Moore</name>
<affiliation wicri:level="1"><nlm:aff id="A76"> The University of Queensland Diamantina Institute, Translational Research Institute; UQ Child Health Research Centre, The University of Queensland; Queensland Children's Medical Research Institute, Children's Health Queensland Hospital and Health Service; Brisbane, Australia.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Australie</country>
<wicri:regionArea> The University of Queensland Diamantina Institute, Translational Research Institute; UQ Child Health Research Centre, The University of Queensland; Queensland Children's Medical Research Institute, Children's Health Queensland Hospital and Health Service; Brisbane</wicri:regionArea>
<wicri:noRegion>Children's Health Queensland Hospital and Health Service; Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Taylor, Michael D" sort="Taylor, Michael D" uniqKey="Taylor M" first="Michael D." last="Taylor">Michael D. Taylor</name>
<affiliation wicri:level="4"><nlm:aff id="A14"> Program in Developmental and Stem Cell Biology, Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Toronto, ON M4N 1X8, Canada.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Canada</country>
<wicri:regionArea> Program in Developmental and Stem Cell Biology, Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Toronto, ON M4N 1X8</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jones, Chris" sort="Jones, Chris" uniqKey="Jones C" first="Chris" last="Jones">Chris Jones</name>
<affiliation wicri:level="3"><nlm:aff id="A13"> Division of Molecular Pathology, The Institute of Cancer Research, SW7 3RP, London, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea> Division of Molecular Pathology, The Institute of Cancer Research, SW7 3RP, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jabado, Nada" sort="Jabado, Nada" uniqKey="Jabado N" first="Nada" last="Jabado">Nada Jabado</name>
<affiliation wicri:level="1"><nlm:aff id="A77"> McGill University and Genome Quebec Innovation Centre, Montreal, QC H3A 1A4, Canada.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Canada</country>
<wicri:regionArea> McGill University and Genome Quebec Innovation Centre, Montreal, QC H3A 1A4</wicri:regionArea>
<wicri:noRegion>QC H3A 1A4</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Karajannis, Matthias A" sort="Karajannis, Matthias A" uniqKey="Karajannis M" first="Matthias A." last="Karajannis">Matthias A. Karajannis</name>
<affiliation wicri:level="2"><nlm:aff id="A78"> Departments of Pediatrics and Otolaryngology, Division of Pediatric Hematology/Oncology, NYU Langone Medical Center and Laura and Isaac Perlmutter Cancer Center, NY 10016, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Departments of Pediatrics and Otolaryngology, Division of Pediatric Hematology/Oncology, NYU Langone Medical Center and Laura and Isaac Perlmutter Cancer Center, NY 10016, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eils, Roland" sort="Eils, Roland" uniqKey="Eils R" first="Roland" last="Eils">Roland Eils</name>
<affiliation wicri:level="3"><nlm:aff id="A4"> Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A79"> Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant, Heidelberg University, Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant, Heidelberg University, Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A80"> Heidelberg Center for Personalized Oncology, DKFZ-HIPO, DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Heidelberg Center for Personalized Oncology, DKFZ-HIPO, DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schlesner, Matthias" sort="Schlesner, Matthias" uniqKey="Schlesner M" first="Matthias" last="Schlesner">Matthias Schlesner</name>
<affiliation wicri:level="3"><nlm:aff id="A4"> Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lichter, Peter" sort="Lichter, Peter" uniqKey="Lichter P" first="Peter" last="Lichter">Peter Lichter</name>
<affiliation wicri:level="3"><nlm:aff id="A5"> Division of Molecular Genetics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Molecular Genetics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A80"> Heidelberg Center for Personalized Oncology, DKFZ-HIPO, DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Heidelberg Center for Personalized Oncology, DKFZ-HIPO, DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Von Deimling, Andreas" sort="Von Deimling, Andreas" uniqKey="Von Deimling A" first="Andreas" last="Von Deimling">Andreas Von Deimling</name>
<affiliation wicri:level="3"><nlm:aff id="A6"> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation><nlm:aff id="A7"> Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg.</nlm:aff>
<wicri:noCountry code="subfield">69120 Heidelberg.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Pfister, Stefan M" sort="Pfister, Stefan M" uniqKey="Pfister S" first="Stefan M." last="Pfister">Stefan M. Pfister</name>
<affiliation wicri:level="3"><nlm:aff id="A1"> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A2"> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ellison, David W" sort="Ellison, David W" uniqKey="Ellison D" first="David W." last="Ellison">David W. Ellison</name>
<affiliation wicri:level="2"><nlm:aff id="A3"> Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105-3678, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105-3678</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Korshunov, Andrey" sort="Korshunov, Andrey" uniqKey="Korshunov A" first="Andrey" last="Korshunov">Andrey Korshunov</name>
<affiliation wicri:level="3"><nlm:aff id="A6"> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation><nlm:aff id="A7"> Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg.</nlm:aff>
<wicri:noCountry code="subfield">69120 Heidelberg.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kool, Marcel" sort="Kool, Marcel" uniqKey="Kool M" first="Marcel" last="Kool">Marcel Kool</name>
<affiliation wicri:level="3"><nlm:aff id="A1"> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs</title>
<author><name sortKey="Sturm, Dominik" sort="Sturm, Dominik" uniqKey="Sturm D" first="Dominik" last="Sturm">Dominik Sturm</name>
<affiliation wicri:level="3"><nlm:aff id="A1"> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
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</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A2"> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
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<author><name sortKey="Orr, Brent A" sort="Orr, Brent A" uniqKey="Orr B" first="Brent A." last="Orr">Brent A. Orr</name>
<affiliation wicri:level="2"><nlm:aff id="A3"> Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105-3678, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105-3678</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Toprak, Umut H" sort="Toprak, Umut H" uniqKey="Toprak U" first="Umut H." last="Toprak">Umut H. Toprak</name>
<affiliation wicri:level="3"><nlm:aff id="A4"> Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
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</affiliation>
</author>
<author><name sortKey="Hovestadt, Volker" sort="Hovestadt, Volker" uniqKey="Hovestadt V" first="Volker" last="Hovestadt">Volker Hovestadt</name>
<affiliation wicri:level="3"><nlm:aff id="A5"> Division of Molecular Genetics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Molecular Genetics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
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<settlement type="city">Heidelberg</settlement>
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</author>
<author><name sortKey="Jones, David T W" sort="Jones, David T W" uniqKey="Jones D" first="David T. W." last="Jones">David T. W. Jones</name>
<affiliation wicri:level="3"><nlm:aff id="A1"> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
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</affiliation>
</author>
<author><name sortKey="Capper, David" sort="Capper, David" uniqKey="Capper D" first="David" last="Capper">David Capper</name>
<affiliation wicri:level="3"><nlm:aff id="A6"> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
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</affiliation>
<affiliation><nlm:aff id="A7"> Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg.</nlm:aff>
<wicri:noCountry code="subfield">69120 Heidelberg.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sill, Martin" sort="Sill, Martin" uniqKey="Sill M" first="Martin" last="Sill">Martin Sill</name>
<affiliation wicri:level="3"><nlm:aff id="A8"> Division of Biostatistics, German Cancer Research Center (DKFZ) Heidelberg and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Biostatistics, German Cancer Research Center (DKFZ) Heidelberg and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Buchhalter, Ivo" sort="Buchhalter, Ivo" uniqKey="Buchhalter I" first="Ivo" last="Buchhalter">Ivo Buchhalter</name>
<affiliation wicri:level="3"><nlm:aff id="A4"> Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Northcott, Paul A" sort="Northcott, Paul A" uniqKey="Northcott P" first="Paul A." last="Northcott">Paul A. Northcott</name>
<affiliation wicri:level="3"><nlm:aff id="A1"> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Leis, Irina" sort="Leis, Irina" uniqKey="Leis I" first="Irina" last="Leis">Irina Leis</name>
<affiliation wicri:level="3"><nlm:aff id="A6"> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ryzhova, Marina" sort="Ryzhova, Marina" uniqKey="Ryzhova M" first="Marina" last="Ryzhova">Marina Ryzhova</name>
<affiliation wicri:level="3"><nlm:aff id="A9"> NN Burdenko Neurosurgical Institute, Moscow, 125047 Russia.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Russie</country>
<wicri:regionArea> NN Burdenko Neurosurgical Institute, Moscow</wicri:regionArea>
<placeName><settlement type="city">Moscou</settlement>
<region>District fédéral central</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Koelsche, Christian" sort="Koelsche, Christian" uniqKey="Koelsche C" first="Christian" last="Koelsche">Christian Koelsche</name>
<affiliation wicri:level="3"><nlm:aff id="A6"> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation><nlm:aff id="A7"> Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg.</nlm:aff>
<wicri:noCountry code="subfield">69120 Heidelberg.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Pfaff, Elke" sort="Pfaff, Elke" uniqKey="Pfaff E" first="Elke" last="Pfaff">Elke Pfaff</name>
<affiliation wicri:level="3"><nlm:aff id="A1"> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A2"> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Allen, Sariah J" sort="Allen, Sariah J" uniqKey="Allen S" first="Sariah J." last="Allen">Sariah J. Allen</name>
<affiliation wicri:level="2"><nlm:aff id="A3"> Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105-3678, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105-3678</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Balasubramanian, Gnanaprakash" sort="Balasubramanian, Gnanaprakash" uniqKey="Balasubramanian G" first="Gnanaprakash" last="Balasubramanian">Gnanaprakash Balasubramanian</name>
<affiliation wicri:level="3"><nlm:aff id="A10"> Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), National Center for Tumor Diseases (NCT), and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), National Center for Tumor Diseases (NCT), and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Worst, Barbara C" sort="Worst, Barbara C" uniqKey="Worst B" first="Barbara C." last="Worst">Barbara C. Worst</name>
<affiliation wicri:level="3"><nlm:aff id="A1"> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A2"> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
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</affiliation>
</author>
<author><name sortKey="Pajtler, Kristian W" sort="Pajtler, Kristian W" uniqKey="Pajtler K" first="Kristian W." last="Pajtler">Kristian W. Pajtler</name>
<affiliation wicri:level="3"><nlm:aff id="A1"> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brabetz, Sebastian" sort="Brabetz, Sebastian" uniqKey="Brabetz S" first="Sebastian" last="Brabetz">Sebastian Brabetz</name>
<affiliation wicri:level="3"><nlm:aff id="A1"> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Johann, Pascal D" sort="Johann, Pascal D" uniqKey="Johann P" first="Pascal D." last="Johann">Pascal D. Johann</name>
<affiliation wicri:level="3"><nlm:aff id="A1"> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A2"> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sahm, Felix" sort="Sahm, Felix" uniqKey="Sahm F" first="Felix" last="Sahm">Felix Sahm</name>
<affiliation wicri:level="3"><nlm:aff id="A6"> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation><nlm:aff id="A7"> Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg.</nlm:aff>
<wicri:noCountry code="subfield">69120 Heidelberg.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Reimand, Juri" sort="Reimand, Juri" uniqKey="Reimand J" first="Jüri" last="Reimand">Jüri Reimand</name>
<affiliation wicri:level="1"><nlm:aff id="A11"> Ontario Institute for Cancer Research, M5G 0A3, Toronto, ON M5G 1L7, Canada.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Canada</country>
<wicri:regionArea> Ontario Institute for Cancer Research, M5G 0A3, Toronto, ON M5G 1L7</wicri:regionArea>
<wicri:noRegion>ON M5G 1L7</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A12"> Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Canada</country>
<wicri:regionArea> Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mackay, Alan" sort="Mackay, Alan" uniqKey="Mackay A" first="Alan" last="Mackay">Alan Mackay</name>
<affiliation wicri:level="3"><nlm:aff id="A13"> Division of Molecular Pathology, The Institute of Cancer Research, SW7 3RP, London, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea> Division of Molecular Pathology, The Institute of Cancer Research, SW7 3RP, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Carvalho, Diana M" sort="Carvalho, Diana M" uniqKey="Carvalho D" first="Diana M." last="Carvalho">Diana M. Carvalho</name>
<affiliation wicri:level="3"><nlm:aff id="A13"> Division of Molecular Pathology, The Institute of Cancer Research, SW7 3RP, London, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea> Division of Molecular Pathology, The Institute of Cancer Research, SW7 3RP, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Remke, Marc" sort="Remke, Marc" uniqKey="Remke M" first="Marc" last="Remke">Marc Remke</name>
<affiliation wicri:level="4"><nlm:aff id="A14"> Program in Developmental and Stem Cell Biology, Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Toronto, ON M4N 1X8, Canada.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Canada</country>
<wicri:regionArea> Program in Developmental and Stem Cell Biology, Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Toronto, ON M4N 1X8</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Phillips, Joanna J" sort="Phillips, Joanna J" uniqKey="Phillips J" first="Joanna J." last="Phillips">Joanna J. Phillips</name>
<affiliation wicri:level="2"><nlm:aff id="A15"> Brain Tumor Research Center, University of California, San Francisco, CA 94158-9001, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Brain Tumor Research Center, University of California, San Francisco, CA 94158-9001</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A16"> Neuropathology, Department of Pathology, University of California, San Francisco, CA 94143-0102, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Neuropathology, Department of Pathology, University of California, San Francisco, CA 94143-0102</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A17"> Department of Neurological Surgery, University of California, San Francisco, CA 94143-0112, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurological Surgery, University of California, San Francisco, CA 94143-0112</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Perry, Arie" sort="Perry, Arie" uniqKey="Perry A" first="Arie" last="Perry">Arie Perry</name>
<affiliation wicri:level="2"><nlm:aff id="A15"> Brain Tumor Research Center, University of California, San Francisco, CA 94158-9001, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Brain Tumor Research Center, University of California, San Francisco, CA 94158-9001</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A16"> Neuropathology, Department of Pathology, University of California, San Francisco, CA 94143-0102, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Neuropathology, Department of Pathology, University of California, San Francisco, CA 94143-0102</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A17"> Department of Neurological Surgery, University of California, San Francisco, CA 94143-0112, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurological Surgery, University of California, San Francisco, CA 94143-0112</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cowdrey, Cynthia" sort="Cowdrey, Cynthia" uniqKey="Cowdrey C" first="Cynthia" last="Cowdrey">Cynthia Cowdrey</name>
<affiliation wicri:level="2"><nlm:aff id="A15"> Brain Tumor Research Center, University of California, San Francisco, CA 94158-9001, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Brain Tumor Research Center, University of California, San Francisco, CA 94158-9001</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Drissi, Rachid" sort="Drissi, Rachid" uniqKey="Drissi R" first="Rachid" last="Drissi">Rachid Drissi</name>
<affiliation wicri:level="2"><nlm:aff id="A18"> Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fouladi, Maryam" sort="Fouladi, Maryam" uniqKey="Fouladi M" first="Maryam" last="Fouladi">Maryam Fouladi</name>
<affiliation wicri:level="2"><nlm:aff id="A18"> Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Giangaspero, Felice" sort="Giangaspero, Felice" uniqKey="Giangaspero F" first="Felice" last="Giangaspero">Felice Giangaspero</name>
<affiliation wicri:level="1"><nlm:aff id="A19"> Department of Radiological, Oncological and Anatomic-Pathological Sciences, Sapienza University of Rome, 00185 Rome, Italy.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Italie</country>
<wicri:regionArea> Department of Radiological, Oncological and Anatomic-Pathological Sciences, Sapienza University of Rome, 00185 Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A20"> IRCCS Neuromed, 86077 Pozzilli, Molise, Italy.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Italie</country>
<wicri:regionArea> IRCCS Neuromed, 86077 Pozzilli, Molise</wicri:regionArea>
<wicri:noRegion>Molise</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lastowska, Maria" sort="Lastowska, Maria" uniqKey="Lastowska M" first="Maria" last="Łastowska">Maria Łastowska</name>
<affiliation wicri:level="1"><nlm:aff id="A21"> Department of Pathology, Children's Memorial Health Institute, 04-730 Warsaw, Poland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pologne</country>
<wicri:regionArea> Department of Pathology, Children's Memorial Health Institute, 04-730 Warsaw</wicri:regionArea>
<wicri:noRegion>04-730 Warsaw</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Grajkowska, Wieslawa" sort="Grajkowska, Wieslawa" uniqKey="Grajkowska W" first="Wiesława" last="Grajkowska">Wiesława Grajkowska</name>
<affiliation wicri:level="1"><nlm:aff id="A21"> Department of Pathology, Children's Memorial Health Institute, 04-730 Warsaw, Poland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pologne</country>
<wicri:regionArea> Department of Pathology, Children's Memorial Health Institute, 04-730 Warsaw</wicri:regionArea>
<wicri:noRegion>04-730 Warsaw</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Scheurlen, Wolfram" sort="Scheurlen, Wolfram" uniqKey="Scheurlen W" first="Wolfram" last="Scheurlen">Wolfram Scheurlen</name>
<affiliation wicri:level="1"><nlm:aff id="A22"> Cnopf'sche Kinderklinik, Nürnberg Children's Hospital, 90419 Nürnberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Cnopf'sche Kinderklinik, Nürnberg Children's Hospital, 90419 Nürnberg</wicri:regionArea>
<wicri:noRegion>90419 Nürnberg</wicri:noRegion>
<wicri:noRegion>90419 Nürnberg</wicri:noRegion>
<wicri:noRegion>90419 Nürnberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pietsch, Torsten" sort="Pietsch, Torsten" uniqKey="Pietsch T" first="Torsten" last="Pietsch">Torsten Pietsch</name>
<affiliation wicri:level="1"><nlm:aff id="A23"> Department of Neuropathology, University of Bonn Medical School, 53105 Bonn, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, University of Bonn Medical School, 53105 Bonn</wicri:regionArea>
<wicri:noRegion>53105 Bonn</wicri:noRegion>
<placeName><settlement type="city">Bonn</settlement>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hagel, Christian" sort="Hagel, Christian" uniqKey="Hagel C" first="Christian" last="Hagel">Christian Hagel</name>
<affiliation wicri:level="1"><nlm:aff id="A24"> Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg</wicri:regionArea>
<wicri:noRegion>20246 Hamburg</wicri:noRegion>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gojo, Johannes" sort="Gojo, Johannes" uniqKey="Gojo J" first="Johannes" last="Gojo">Johannes Gojo</name>
<affiliation wicri:level="3"><nlm:aff id="A25"> Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, 1090 Vienna, Austria.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Autriche</country>
<wicri:regionArea> Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, 1090 Vienna</wicri:regionArea>
<placeName><region type="land" nuts="2">Vienne (Autriche)</region>
<settlement type="city">Vienne (Autriche)</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A26"> Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Autriche</country>
<wicri:regionArea> Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna</wicri:regionArea>
<placeName><region type="land" nuts="2">Vienne (Autriche)</region>
<settlement type="city">Vienne (Autriche)</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lotsch, Daniela" sort="Lotsch, Daniela" uniqKey="Lotsch D" first="Daniela" last="Lötsch">Daniela Lötsch</name>
<affiliation wicri:level="3"><nlm:aff id="A26"> Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Autriche</country>
<wicri:regionArea> Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna</wicri:regionArea>
<placeName><region type="land" nuts="2">Vienne (Autriche)</region>
<settlement type="city">Vienne (Autriche)</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Berger, Walter" sort="Berger, Walter" uniqKey="Berger W" first="Walter" last="Berger">Walter Berger</name>
<affiliation wicri:level="3"><nlm:aff id="A26"> Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Autriche</country>
<wicri:regionArea> Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna</wicri:regionArea>
<placeName><region type="land" nuts="2">Vienne (Autriche)</region>
<settlement type="city">Vienne (Autriche)</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Slavc, Irene" sort="Slavc, Irene" uniqKey="Slavc I" first="Irene" last="Slavc">Irene Slavc</name>
<affiliation wicri:level="3"><nlm:aff id="A25"> Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, 1090 Vienna, Austria.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Autriche</country>
<wicri:regionArea> Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, 1090 Vienna</wicri:regionArea>
<placeName><region type="land" nuts="2">Vienne (Autriche)</region>
<settlement type="city">Vienne (Autriche)</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Haberler, Christine" sort="Haberler, Christine" uniqKey="Haberler C" first="Christine" last="Haberler">Christine Haberler</name>
<affiliation wicri:level="3"><nlm:aff id="A27"> Institute of Neurology, Medical University of Vienna, 1097 Vienna, Austria.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Autriche</country>
<wicri:regionArea> Institute of Neurology, Medical University of Vienna, 1097 Vienna</wicri:regionArea>
<placeName><region type="land" nuts="2">Vienne (Autriche)</region>
<settlement type="city">Vienne (Autriche)</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jouvet, Anne" sort="Jouvet, Anne" uniqKey="Jouvet A" first="Anne" last="Jouvet">Anne Jouvet</name>
<affiliation wicri:level="1"><nlm:aff id="A28"> Neuro-Oncology and Neuro-Inflammation Team, Inserm U1028, CNRS UMR 5292, University Lyon-1, Neuroscience Center, 69000 Lyon, France, and Centre de Pathologie et de Neuropathologie Est, Hospices Civils de Lyon, 69003 Lyon, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea> Neuro-Oncology and Neuro-Inflammation Team, Inserm U1028, CNRS UMR 5292, University Lyon-1, Neuroscience Center, 69000 Lyon, France, and Centre de Pathologie et de Neuropathologie Est, Hospices Civils de Lyon, 69003 Lyon</wicri:regionArea>
<wicri:noRegion>69003 Lyon</wicri:noRegion>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Holm, Stefan" sort="Holm, Stefan" uniqKey="Holm S" first="Stefan" last="Holm">Stefan Holm</name>
<affiliation wicri:level="1"><nlm:aff id="A29"> Department of Women's and Children's Health (KBH), Karolinska Institutet, SE-171 77 Stockholm, Sweden.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Suède</country>
<wicri:regionArea> Department of Women's and Children's Health (KBH), Karolinska Institutet, SE-171 77 Stockholm</wicri:regionArea>
<wicri:noRegion>SE-171 77 Stockholm</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hofer, Silvia" sort="Hofer, Silvia" uniqKey="Hofer S" first="Silvia" last="Hofer">Silvia Hofer</name>
<affiliation wicri:level="1"><nlm:aff id="A30"> Department of Oncology, Luzerner Kantonsspital, 6000 Luzern 16, Luzern, Switzerland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Suisse</country>
<wicri:regionArea> Department of Oncology, Luzerner Kantonsspital, 6000 Luzern 16, Luzern</wicri:regionArea>
<wicri:noRegion>Luzern</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Prinz, Marco" sort="Prinz, Marco" uniqKey="Prinz M" first="Marco" last="Prinz">Marco Prinz</name>
<affiliation wicri:level="3"><nlm:aff id="A31"> Institute of Neuropathology, University of Freiburg, Germany & BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79106 Freiburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Institute of Neuropathology, University of Freiburg, Germany & BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79106 Freiburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Fribourg-en-Brisgau</region>
<settlement type="city">Fribourg-en-Brisgau</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Keohane, Catherine" sort="Keohane, Catherine" uniqKey="Keohane C" first="Catherine" last="Keohane">Catherine Keohane</name>
<affiliation wicri:level="1"><nlm:aff id="A32"> Department of Pathology, University College Cork and Cork University Hospital Wilton, Cork, Ireland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Irlande (pays)</country>
<wicri:regionArea> Department of Pathology, University College Cork and Cork University Hospital Wilton, Cork</wicri:regionArea>
<wicri:noRegion>Cork</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fried, Iris" sort="Fried, Iris" uniqKey="Fried I" first="Iris" last="Fried">Iris Fried</name>
<affiliation wicri:level="1"><nlm:aff id="A33"> Department of Pediatric Hematology and Oncology, Hadassah Medical Center, Jerusalem, Israel.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Israël</country>
<wicri:regionArea> Department of Pediatric Hematology and Oncology, Hadassah Medical Center, Jerusalem</wicri:regionArea>
<wicri:noRegion>Jerusalem</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mawrin, Christian" sort="Mawrin, Christian" uniqKey="Mawrin C" first="Christian" last="Mawrin">Christian Mawrin</name>
<affiliation wicri:level="3"><nlm:aff id="A34"> Institute of Neuropathology, University Hospital, Otto-von-Guericke University, 39120 Magdeburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Institute of Neuropathology, University Hospital, Otto-von-Guericke University, 39120 Magdeburg</wicri:regionArea>
<placeName><region type="land" nuts="2">Saxe-Anhalt</region>
<settlement type="city">Magdebourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Scheie, David" sort="Scheie, David" uniqKey="Scheie D" first="David" last="Scheie">David Scheie</name>
<affiliation wicri:level="1"><nlm:aff id="A35"> Department of Pathology, Copenhagen University Hospital, 2100 København Ø, Denmark.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Danemark</country>
<wicri:regionArea> Department of Pathology, Copenhagen University Hospital, 2100 København Ø</wicri:regionArea>
<wicri:noRegion>2100 København Ø</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mobley, Bret C" sort="Mobley, Bret C" uniqKey="Mobley B" first="Bret C." last="Mobley">Bret C. Mobley</name>
<affiliation wicri:level="2"><nlm:aff id="A36"> Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schniederjan, Matthew J" sort="Schniederjan, Matthew J" uniqKey="Schniederjan M" first="Matthew J." last="Schniederjan">Matthew J. Schniederjan</name>
<affiliation wicri:level="2"><nlm:aff id="A37"> Department of Pathology and Laboratory Administration, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Pathology and Laboratory Administration, Children's Healthcare of Atlanta, Atlanta, GA 30322</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Santi, Mariarita" sort="Santi, Mariarita" uniqKey="Santi M" first="Mariarita" last="Santi">Mariarita Santi</name>
<affiliation wicri:level="2"><nlm:aff id="A38"> Department of Pathology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Pathology, Children's Hospital of Philadelphia, Philadelphia, PA 19104</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Buccoliero, Anna M" sort="Buccoliero, Anna M" uniqKey="Buccoliero A" first="Anna M." last="Buccoliero">Anna M. Buccoliero</name>
<affiliation wicri:level="1"><nlm:aff id="A39"> Pathology Unit, Anna Meyer Children's University Hospital, 50141 Florence, Italy.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Italie</country>
<wicri:regionArea> Pathology Unit, Anna Meyer Children's University Hospital, 50141 Florence</wicri:regionArea>
<wicri:noRegion>50141 Florence</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dahiya, Sonika" sort="Dahiya, Sonika" uniqKey="Dahiya S" first="Sonika" last="Dahiya">Sonika Dahiya</name>
<affiliation wicri:level="2"><nlm:aff id="A40"> Department of Pathology and Immunology, Washington University, St. Louis, MO 63110, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Pathology and Immunology, Washington University, St. Louis, MO 63110</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kramm, Christof M" sort="Kramm, Christof M" uniqKey="Kramm C" first="Christof M." last="Kramm">Christof M. Kramm</name>
<affiliation wicri:level="3"><nlm:aff id="A41"> Division of Pediatric Hematology and Oncology, Department of Child and Adolescent Health, University Medical Center Göttingen, 37075 Göttingen, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Hematology and Oncology, Department of Child and Adolescent Health, University Medical Center Göttingen, 37075 Göttingen</wicri:regionArea>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Göttingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Von Bueren, Andre O" sort="Von Bueren, Andre O" uniqKey="Von Bueren A" first="André O." last="Von Bueren">André O. Von Bueren</name>
<affiliation wicri:level="3"><nlm:aff id="A41"> Division of Pediatric Hematology and Oncology, Department of Child and Adolescent Health, University Medical Center Göttingen, 37075 Göttingen, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Hematology and Oncology, Department of Child and Adolescent Health, University Medical Center Göttingen, 37075 Göttingen</wicri:regionArea>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Göttingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Von Hoff, Katja" sort="Von Hoff, Katja" uniqKey="Von Hoff K" first="Katja" last="Von Hoff">Katja Von Hoff</name>
<affiliation wicri:level="1"><nlm:aff id="A42"> Department of Pediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg</wicri:regionArea>
<wicri:noRegion>20246 Hamburg</wicri:noRegion>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rutkowski, Stefan" sort="Rutkowski, Stefan" uniqKey="Rutkowski S" first="Stefan" last="Rutkowski">Stefan Rutkowski</name>
<affiliation wicri:level="1"><nlm:aff id="A42"> Department of Pediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg</wicri:regionArea>
<wicri:noRegion>20246 Hamburg</wicri:noRegion>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Herold Mende, Christel" sort="Herold Mende, Christel" uniqKey="Herold Mende C" first="Christel" last="Herold-Mende">Christel Herold-Mende</name>
<affiliation wicri:level="3"><nlm:aff id="A43"> Department of Neurosurgery, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neurosurgery, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fruhwald, Michael C" sort="Fruhwald, Michael C" uniqKey="Fruhwald M" first="Michael C." last="Frühwald">Michael C. Frühwald</name>
<affiliation wicri:level="3"><nlm:aff id="A44"> Pediatric Hospital, Klinikum Augsburg, 86156 Augsburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Pediatric Hospital, Klinikum Augsburg, 86156 Augsburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Souabe</region>
<settlement type="city">Augsbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Milde, Till" sort="Milde, Till" uniqKey="Milde T" first="Till" last="Milde">Till Milde</name>
<affiliation wicri:level="3"><nlm:aff id="A2"> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A45"> Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hasselblatt, Martin" sort="Hasselblatt, Martin" uniqKey="Hasselblatt M" first="Martin" last="Hasselblatt">Martin Hasselblatt</name>
<affiliation wicri:level="3"><nlm:aff id="A46"> Institute of Neuropathology, University Hospital Münster, 48149 Münster, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Institute of Neuropathology, University Hospital Münster, 48149 Münster</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Münster</region>
<settlement type="city">Münster</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wesseling, Pieter" sort="Wesseling, Pieter" uniqKey="Wesseling P" first="Pieter" last="Wesseling">Pieter Wesseling</name>
<affiliation wicri:level="1"><nlm:aff id="A47"> Department of Pathology, VU University Medical Center Amsterdam, 1008 MB Amsterdam, The Netherlands.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea> Department of Pathology, VU University Medical Center Amsterdam, 1008 MB Amsterdam</wicri:regionArea>
<wicri:noRegion>1008 MB Amsterdam</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A48"> Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, 6525 GA, The Netherlands.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea> Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, 6525 GA</wicri:regionArea>
<wicri:noRegion>6525 GA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ro Ler, Jochen" sort="Ro Ler, Jochen" uniqKey="Ro Ler J" first="Jochen" last="Rö Ler">Jochen Rö Ler</name>
<affiliation wicri:level="3"><nlm:aff id="A49"> Department of Pediatric Hematology/Oncology, Center of Pediatrics and Adolescent Medicine, University Medical Center Freiburg, 79106 Freiburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Hematology/Oncology, Center of Pediatrics and Adolescent Medicine, University Medical Center Freiburg, 79106 Freiburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Fribourg-en-Brisgau</region>
<settlement type="city">Fribourg-en-Brisgau</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schuller, Ulrich" sort="Schuller, Ulrich" uniqKey="Schuller U" first="Ulrich" last="Schüller">Ulrich Schüller</name>
<affiliation wicri:level="4"><nlm:aff id="A50"> Department of Neuropathology, Ludwig-Maximilians-University, and German Cancer Consortium (DKTK) partner site Munich, 81377 Munich, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Ludwig-Maximilians-University, and German Cancer Consortium (DKTK) partner site Munich, 81377 Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
</author>
<author><name sortKey="Ebinger, Martin" sort="Ebinger, Martin" uniqKey="Ebinger M" first="Martin" last="Ebinger">Martin Ebinger</name>
<affiliation wicri:level="1"><nlm:aff id="A51"> Department of Hematology and Oncology, Children's University Hospital Tübingen, and German Cancer Consortium (DKTK) partner site Tübingen, 72076 Tübingen, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Hematology and Oncology, Children's University Hospital Tübingen, and German Cancer Consortium (DKTK) partner site Tübingen, 72076 Tübingen</wicri:regionArea>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schittenhelm, Jens" sort="Schittenhelm, Jens" uniqKey="Schittenhelm J" first="Jens" last="Schittenhelm">Jens Schittenhelm</name>
<affiliation wicri:level="1"><nlm:aff id="A52"> Department of Neuropathology, Institute of Pathology and Neuropathology, University of Tübingen, and German Cancer Consortium (DKTK) partner site Tübingen, 72076 Tübingen, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Institute of Pathology and Neuropathology, University of Tübingen, and German Cancer Consortium (DKTK) partner site Tübingen, 72076 Tübingen</wicri:regionArea>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Frank, Stephan" sort="Frank, Stephan" uniqKey="Frank S" first="Stephan" last="Frank">Stephan Frank</name>
<affiliation wicri:level="1"><nlm:aff id="A53"> Department of Neuropathology, Institute of Pathology, Basel University Hospital, 4031 Basel, Switzerland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Suisse</country>
<wicri:regionArea> Department of Neuropathology, Institute of Pathology, Basel University Hospital, 4031 Basel</wicri:regionArea>
<wicri:noRegion>4031 Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Grobholz, Rainer" sort="Grobholz, Rainer" uniqKey="Grobholz R" first="Rainer" last="Grobholz">Rainer Grobholz</name>
<affiliation wicri:level="1"><nlm:aff id="A54"> Department of Pathology, Medical Center Aarau, 5001 Aarau, Switzerland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Suisse</country>
<wicri:regionArea> Department of Pathology, Medical Center Aarau, 5001 Aarau</wicri:regionArea>
<wicri:noRegion>5001 Aarau</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vajtai, Istvan" sort="Vajtai, Istvan" uniqKey="Vajtai I" first="Istvan" last="Vajtai">Istvan Vajtai</name>
<affiliation wicri:level="1"><nlm:aff id="A55"> Department of Pathology, University Hospital Bern, 3010 Bern, Switzerland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Suisse</country>
<wicri:regionArea> Department of Pathology, University Hospital Bern, 3010 Bern</wicri:regionArea>
<placeName><settlement type="city">Berne</settlement>
<region type="région" nuts="3">Canton de Berne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hans, Volkmar" sort="Hans, Volkmar" uniqKey="Hans V" first="Volkmar" last="Hans">Volkmar Hans</name>
<affiliation wicri:level="1"><nlm:aff id="A56"> Department of Neuropathology, Medical Center Bielefeld, 33617 Bielefeld, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Medical Center Bielefeld, 33617 Bielefeld</wicri:regionArea>
<wicri:noRegion>33617 Bielefeld</wicri:noRegion>
<wicri:noRegion>33617 Bielefeld</wicri:noRegion>
<wicri:noRegion>33617 Bielefeld</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schneppenheim, Reinhard" sort="Schneppenheim, Reinhard" uniqKey="Schneppenheim R" first="Reinhard" last="Schneppenheim">Reinhard Schneppenheim</name>
<affiliation wicri:level="1"><nlm:aff id="A42"> Department of Pediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg</wicri:regionArea>
<wicri:noRegion>20246 Hamburg</wicri:noRegion>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zitterbart, Karel" sort="Zitterbart, Karel" uniqKey="Zitterbart K" first="Karel" last="Zitterbart">Karel Zitterbart</name>
<affiliation wicri:level="1"><nlm:aff id="A57"> Department of Pediatric Oncology, University Hospital Brno and Masaryk University, Faculty of Medicine, 613 00 Brno, Czech Republic.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République tchèque</country>
<wicri:regionArea> Department of Pediatric Oncology, University Hospital Brno and Masaryk University, Faculty of Medicine, 613 00 Brno</wicri:regionArea>
<wicri:noRegion>613 00 Brno</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Collins, V Peter" sort="Collins, V Peter" uniqKey="Collins V" first="V. Peter" last="Collins">V. Peter Collins</name>
<affiliation wicri:level="4"><nlm:aff id="A58"> Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea> Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, CB2 0QQ</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Aronica, Eleonora" sort="Aronica, Eleonora" uniqKey="Aronica E" first="Eleonora" last="Aronica">Eleonora Aronica</name>
<affiliation wicri:level="4"><nlm:aff id="A59"> Department of Neuropathology, AMC, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea> Department of Neuropathology, AMC, University of Amsterdam, Amsterdam, 1105 AZ</wicri:regionArea>
<orgName type="university">Université d'Amsterdam</orgName>
<placeName><settlement type="city">Amsterdam</settlement>
<region>Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Varlet, Pascale" sort="Varlet, Pascale" uniqKey="Varlet P" first="Pascale" last="Varlet">Pascale Varlet</name>
<affiliation wicri:level="3"><nlm:aff id="A60"> Department of Neuropathology, Hôpital Sainte-Anne, 75674, Paris, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea> Department of Neuropathology, Hôpital Sainte-Anne, 75674, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Puget, Stephanie" sort="Puget, Stephanie" uniqKey="Puget S" first="Stephanie" last="Puget">Stephanie Puget</name>
<affiliation wicri:level="3"><nlm:aff id="A61"> Pediatric Neurosurgery Department, Necker Enfants Malades Hospital, 75015, Paris, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea> Pediatric Neurosurgery Department, Necker Enfants Malades Hospital, 75015, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dufour, Christelle" sort="Dufour, Christelle" uniqKey="Dufour C" first="Christelle" last="Dufour">Christelle Dufour</name>
<affiliation wicri:level="1"><nlm:aff id="A62"> Brain Tumor Program, Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Institute, University Paris Sud, 94805, Villejuif, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea> Brain Tumor Program, Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Institute, University Paris Sud, 94805, Villejuif</wicri:regionArea>
<wicri:noRegion>94805, Villejuif</wicri:noRegion>
<wicri:noRegion>94805, Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Grill, Jacques" sort="Grill, Jacques" uniqKey="Grill J" first="Jacques" last="Grill">Jacques Grill</name>
<affiliation wicri:level="1"><nlm:aff id="A62"> Brain Tumor Program, Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Institute, University Paris Sud, 94805, Villejuif, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea> Brain Tumor Program, Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Institute, University Paris Sud, 94805, Villejuif</wicri:regionArea>
<wicri:noRegion>94805, Villejuif</wicri:noRegion>
<wicri:noRegion>94805, Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Figarella Branger, Dominique" sort="Figarella Branger, Dominique" uniqKey="Figarella Branger D" first="Dominique" last="Figarella-Branger">Dominique Figarella-Branger</name>
<affiliation wicri:level="1"><nlm:aff id="A63"> Department of Pathology and Neuropathology, la Timone Hospital, AP-HM and UMR911 CR02, Aix-Marseille University, 13385 Marseille, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea> Department of Pathology and Neuropathology, la Timone Hospital, AP-HM and UMR911 CR02, Aix-Marseille University, 13385 Marseille</wicri:regionArea>
<wicri:noRegion>13385 Marseille</wicri:noRegion>
<placeName><settlement type="city">Marseille</settlement>
<region type="région" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wolter, Marietta" sort="Wolter, Marietta" uniqKey="Wolter M" first="Marietta" last="Wolter">Marietta Wolter</name>
<affiliation wicri:level="3"><nlm:aff id="A64"> Department of Neuropathology, Heinrich-Heine-University, and German Cancer Consortium (DKTK) partner site Essen/Düsseldorf, 40225 Düsseldorf, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Heinrich-Heine-University, and German Cancer Consortium (DKTK) partner site Essen/Düsseldorf, 40225 Düsseldorf</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schuhmann, Martin U" sort="Schuhmann, Martin U" uniqKey="Schuhmann M" first="Martin U." last="Schuhmann">Martin U. Schuhmann</name>
<affiliation wicri:level="1"><nlm:aff id="A65"> Department of Neurosurgery, Section of Pediatric Neurosurgery, University Hospital Tübingen, and German Cancer Consortium (DKTK) partner site Tübingen, 72076 Tübingen, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neurosurgery, Section of Pediatric Neurosurgery, University Hospital Tübingen, and German Cancer Consortium (DKTK) partner site Tübingen, 72076 Tübingen</wicri:regionArea>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shalaby, Tarek" sort="Shalaby, Tarek" uniqKey="Shalaby T" first="Tarek" last="Shalaby">Tarek Shalaby</name>
<affiliation wicri:level="1"><nlm:aff id="A66"> Neuro-Oncology Program, Division of Oncology, University Children's Hospital Zurich, 8032 Zürich, Switzerland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Suisse</country>
<wicri:regionArea> Neuro-Oncology Program, Division of Oncology, University Children's Hospital Zurich, 8032 Zürich</wicri:regionArea>
<placeName><settlement type="city">Zurich</settlement>
<region nuts="3" type="region">Canton de Zurich</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grotzer, Michael" sort="Grotzer, Michael" uniqKey="Grotzer M" first="Michael" last="Grotzer">Michael Grotzer</name>
<affiliation wicri:level="1"><nlm:aff id="A66"> Neuro-Oncology Program, Division of Oncology, University Children's Hospital Zurich, 8032 Zürich, Switzerland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Suisse</country>
<wicri:regionArea> Neuro-Oncology Program, Division of Oncology, University Children's Hospital Zurich, 8032 Zürich</wicri:regionArea>
<placeName><settlement type="city">Zurich</settlement>
<region nuts="3" type="region">Canton de Zurich</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Meter, Timothy" sort="Van Meter, Timothy" uniqKey="Van Meter T" first="Timothy" last="Van Meter">Timothy Van Meter</name>
<affiliation wicri:level="2"><nlm:aff id="A67"> Virginia Commonwealth University, Richmond, VA 23298, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Virginia Commonwealth University, Richmond, VA 23298</wicri:regionArea>
<placeName><region type="state">Virginie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Monoranu, Camelia Maria" sort="Monoranu, Camelia Maria" uniqKey="Monoranu C" first="Camelia-Maria" last="Monoranu">Camelia-Maria Monoranu</name>
<affiliation wicri:level="3"><nlm:aff id="A68"> Department of Neuropathology, Institute of Pathology, University of Würzburg, and Comprehensive Cancer Center (CCC) Mainfranken, University and University Hospital, 97080 Würzburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Institute of Pathology, University of Würzburg, and Comprehensive Cancer Center (CCC) Mainfranken, University and University Hospital, 97080 Würzburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Basse-Franconie</region>
<settlement type="city">Wurtzbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Felsberg, Jorg" sort="Felsberg, Jorg" uniqKey="Felsberg J" first="Jörg" last="Felsberg">Jörg Felsberg</name>
<affiliation wicri:level="3"><nlm:aff id="A64"> Department of Neuropathology, Heinrich-Heine-University, and German Cancer Consortium (DKTK) partner site Essen/Düsseldorf, 40225 Düsseldorf, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Heinrich-Heine-University, and German Cancer Consortium (DKTK) partner site Essen/Düsseldorf, 40225 Düsseldorf</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Reifenberger, Guido" sort="Reifenberger, Guido" uniqKey="Reifenberger G" first="Guido" last="Reifenberger">Guido Reifenberger</name>
<affiliation wicri:level="3"><nlm:aff id="A64"> Department of Neuropathology, Heinrich-Heine-University, and German Cancer Consortium (DKTK) partner site Essen/Düsseldorf, 40225 Düsseldorf, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Heinrich-Heine-University, and German Cancer Consortium (DKTK) partner site Essen/Düsseldorf, 40225 Düsseldorf</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Snuderl, Matija" sort="Snuderl, Matija" uniqKey="Snuderl M" first="Matija" last="Snuderl">Matija Snuderl</name>
<affiliation wicri:level="2"><nlm:aff id="A69"> Department of Pathology, Division of Neuropathology, NYU Langone Medical Center, New York, NY 10016, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Pathology, Division of Neuropathology, NYU Langone Medical Center, New York, NY 10016</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Forrester, Lynn Ann" sort="Forrester, Lynn Ann" uniqKey="Forrester L" first="Lynn Ann" last="Forrester">Lynn Ann Forrester</name>
<affiliation wicri:level="2"><nlm:aff id="A70"> NYU School of Medicine, New York, NY 10016, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> NYU School of Medicine, New York, NY 10016</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Koster, Jan" sort="Koster, Jan" uniqKey="Koster J" first="Jan" last="Koster">Jan Koster</name>
<affiliation wicri:level="4"><nlm:aff id="A71"> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ</wicri:regionArea>
<orgName type="university">Université d'Amsterdam</orgName>
<placeName><settlement type="city">Amsterdam</settlement>
<region>Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Versteeg, Rogier" sort="Versteeg, Rogier" uniqKey="Versteeg R" first="Rogier" last="Versteeg">Rogier Versteeg</name>
<affiliation wicri:level="4"><nlm:aff id="A71"> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ</wicri:regionArea>
<orgName type="university">Université d'Amsterdam</orgName>
<placeName><settlement type="city">Amsterdam</settlement>
<region>Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Volckmann, Richard" sort="Volckmann, Richard" uniqKey="Volckmann R" first="Richard" last="Volckmann">Richard Volckmann</name>
<affiliation wicri:level="4"><nlm:aff id="A71"> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ</wicri:regionArea>
<orgName type="university">Université d'Amsterdam</orgName>
<placeName><settlement type="city">Amsterdam</settlement>
<region>Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Sluis, Peter" sort="Van Sluis, Peter" uniqKey="Van Sluis P" first="Peter" last="Van Sluis">Peter Van Sluis</name>
<affiliation wicri:level="4"><nlm:aff id="A71"> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ</wicri:regionArea>
<orgName type="university">Université d'Amsterdam</orgName>
<placeName><settlement type="city">Amsterdam</settlement>
<region>Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wolf, Stephan" sort="Wolf, Stephan" uniqKey="Wolf S" first="Stephan" last="Wolf">Stephan Wolf</name>
<affiliation wicri:level="3"><nlm:aff id="A72"> Genomics and Proteomics Core Facility, High Throughput Sequencing Unit, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Genomics and Proteomics Core Facility, High Throughput Sequencing Unit, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mikkelsen, Tom" sort="Mikkelsen, Tom" uniqKey="Mikkelsen T" first="Tom" last="Mikkelsen">Tom Mikkelsen</name>
<affiliation wicri:level="2"><nlm:aff id="A73"> Departments of Neurology and Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Departments of Neurology and Neurosurgery, Henry Ford Hospital, Detroit, MI 48202</wicri:regionArea>
<placeName><region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gajjar, Amar" sort="Gajjar, Amar" uniqKey="Gajjar A" first="Amar" last="Gajjar">Amar Gajjar</name>
<affiliation wicri:level="2"><nlm:aff id="A74"> Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Aldape, Kenneth" sort="Aldape, Kenneth" uniqKey="Aldape K" first="Kenneth" last="Aldape">Kenneth Aldape</name>
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<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neuro-Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moore, Andrew S" sort="Moore, Andrew S" uniqKey="Moore A" first="Andrew S." last="Moore">Andrew S. Moore</name>
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<country xml:lang="fr" wicri:curation="lc">Australie</country>
<wicri:regionArea> The University of Queensland Diamantina Institute, Translational Research Institute; UQ Child Health Research Centre, The University of Queensland; Queensland Children's Medical Research Institute, Children's Health Queensland Hospital and Health Service; Brisbane</wicri:regionArea>
<wicri:noRegion>Children's Health Queensland Hospital and Health Service; Brisbane</wicri:noRegion>
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</author>
<author><name sortKey="Taylor, Michael D" sort="Taylor, Michael D" uniqKey="Taylor M" first="Michael D." last="Taylor">Michael D. Taylor</name>
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<country xml:lang="fr" wicri:curation="lc">Canada</country>
<wicri:regionArea> Program in Developmental and Stem Cell Biology, Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Toronto, ON M4N 1X8</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jones, Chris" sort="Jones, Chris" uniqKey="Jones C" first="Chris" last="Jones">Chris Jones</name>
<affiliation wicri:level="3"><nlm:aff id="A13"> Division of Molecular Pathology, The Institute of Cancer Research, SW7 3RP, London, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea> Division of Molecular Pathology, The Institute of Cancer Research, SW7 3RP, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jabado, Nada" sort="Jabado, Nada" uniqKey="Jabado N" first="Nada" last="Jabado">Nada Jabado</name>
<affiliation wicri:level="1"><nlm:aff id="A77"> McGill University and Genome Quebec Innovation Centre, Montreal, QC H3A 1A4, Canada.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Canada</country>
<wicri:regionArea> McGill University and Genome Quebec Innovation Centre, Montreal, QC H3A 1A4</wicri:regionArea>
<wicri:noRegion>QC H3A 1A4</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Karajannis, Matthias A" sort="Karajannis, Matthias A" uniqKey="Karajannis M" first="Matthias A." last="Karajannis">Matthias A. Karajannis</name>
<affiliation wicri:level="2"><nlm:aff id="A78"> Departments of Pediatrics and Otolaryngology, Division of Pediatric Hematology/Oncology, NYU Langone Medical Center and Laura and Isaac Perlmutter Cancer Center, NY 10016, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Departments of Pediatrics and Otolaryngology, Division of Pediatric Hematology/Oncology, NYU Langone Medical Center and Laura and Isaac Perlmutter Cancer Center, NY 10016, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eils, Roland" sort="Eils, Roland" uniqKey="Eils R" first="Roland" last="Eils">Roland Eils</name>
<affiliation wicri:level="3"><nlm:aff id="A4"> Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A79"> Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant, Heidelberg University, Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant, Heidelberg University, Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A80"> Heidelberg Center for Personalized Oncology, DKFZ-HIPO, DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Heidelberg Center for Personalized Oncology, DKFZ-HIPO, DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schlesner, Matthias" sort="Schlesner, Matthias" uniqKey="Schlesner M" first="Matthias" last="Schlesner">Matthias Schlesner</name>
<affiliation wicri:level="3"><nlm:aff id="A4"> Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lichter, Peter" sort="Lichter, Peter" uniqKey="Lichter P" first="Peter" last="Lichter">Peter Lichter</name>
<affiliation wicri:level="3"><nlm:aff id="A5"> Division of Molecular Genetics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Molecular Genetics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A80"> Heidelberg Center for Personalized Oncology, DKFZ-HIPO, DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Heidelberg Center for Personalized Oncology, DKFZ-HIPO, DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Von Deimling, Andreas" sort="Von Deimling, Andreas" uniqKey="Von Deimling A" first="Andreas" last="Von Deimling">Andreas Von Deimling</name>
<affiliation wicri:level="3"><nlm:aff id="A6"> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation><nlm:aff id="A7"> Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg.</nlm:aff>
<wicri:noCountry code="subfield">69120 Heidelberg.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Pfister, Stefan M" sort="Pfister, Stefan M" uniqKey="Pfister S" first="Stefan M." last="Pfister">Stefan M. Pfister</name>
<affiliation wicri:level="3"><nlm:aff id="A1"> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A2"> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ellison, David W" sort="Ellison, David W" uniqKey="Ellison D" first="David W." last="Ellison">David W. Ellison</name>
<affiliation wicri:level="2"><nlm:aff id="A3"> Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105-3678, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105-3678</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Korshunov, Andrey" sort="Korshunov, Andrey" uniqKey="Korshunov A" first="Andrey" last="Korshunov">Andrey Korshunov</name>
<affiliation wicri:level="3"><nlm:aff id="A6"> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation><nlm:aff id="A7"> Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg.</nlm:aff>
<wicri:noCountry code="subfield">69120 Heidelberg.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kool, Marcel" sort="Kool, Marcel" uniqKey="Kool M" first="Marcel" last="Kool">Marcel Kool</name>
<affiliation wicri:level="3"><nlm:aff id="A1"> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Cell</title>
<idno type="ISSN">0092-8674</idno>
<idno type="eISSN">1097-4172</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Central Nervous System Neoplasms (classification)</term>
<term>Central Nervous System Neoplasms (diagnosis)</term>
<term>Central Nervous System Neoplasms (genetics)</term>
<term>Central Nervous System Neoplasms (pathology)</term>
<term>Child</term>
<term>DNA Methylation</term>
<term>Forkhead Transcription Factors (genetics)</term>
<term>Gene Expression Profiling</term>
<term>Gene Expression Regulation, Neoplastic</term>
<term>Humans</term>
<term>Molecular Sequence Data</term>
<term>Neuroectodermal Tumors (classification)</term>
<term>Neuroectodermal Tumors (diagnosis)</term>
<term>Neuroectodermal Tumors (genetics)</term>
<term>Neuroectodermal Tumors (pathology)</term>
<term>Proto-Oncogene Proteins (chemistry)</term>
<term>Proto-Oncogene Proteins (genetics)</term>
<term>Repressor Proteins (chemistry)</term>
<term>Repressor Proteins (genetics)</term>
<term>Signal Transduction</term>
<term>Tumor Suppressor Proteins (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term>
<term>Données de séquences moléculaires</term>
<term>Enfant</term>
<term>Facteurs de transcription Forkhead (génétique)</term>
<term>Humains</term>
<term>Méthylation de l'ADN</term>
<term>Protéines de répression ()</term>
<term>Protéines de répression (génétique)</term>
<term>Protéines proto-oncogènes ()</term>
<term>Protéines proto-oncogènes (génétique)</term>
<term>Protéines suppresseurs de tumeurs (génétique)</term>
<term>Régulation de l'expression des gènes tumoraux</term>
<term>Séquence d'acides aminés</term>
<term>Transduction du signal</term>
<term>Tumeurs du système nerveux central ()</term>
<term>Tumeurs du système nerveux central (anatomopathologie)</term>
<term>Tumeurs du système nerveux central (diagnostic)</term>
<term>Tumeurs du système nerveux central (génétique)</term>
<term>Tumeurs neuroectodermiques ()</term>
<term>Tumeurs neuroectodermiques (anatomopathologie)</term>
<term>Tumeurs neuroectodermiques (diagnostic)</term>
<term>Tumeurs neuroectodermiques (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Proto-Oncogene Proteins</term>
<term>Repressor Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Forkhead Transcription Factors</term>
<term>Proto-Oncogene Proteins</term>
<term>Repressor Proteins</term>
<term>Tumor Suppressor Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs du système nerveux central</term>
<term>Tumeurs neuroectodermiques</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Central Nervous System Neoplasms</term>
<term>Neuroectodermal Tumors</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Central Nervous System Neoplasms</term>
<term>Neuroectodermal Tumors</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Tumeurs du système nerveux central</term>
<term>Tumeurs neuroectodermiques</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Central Nervous System Neoplasms</term>
<term>Neuroectodermal Tumors</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteurs de transcription Forkhead</term>
<term>Protéines de répression</term>
<term>Protéines proto-oncogènes</term>
<term>Protéines suppresseurs de tumeurs</term>
<term>Tumeurs du système nerveux central</term>
<term>Tumeurs neuroectodermiques</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Central Nervous System Neoplasms</term>
<term>Neuroectodermal Tumors</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Child</term>
<term>DNA Methylation</term>
<term>Gene Expression Profiling</term>
<term>Gene Expression Regulation, Neoplastic</term>
<term>Humans</term>
<term>Molecular Sequence Data</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term>
<term>Données de séquences moléculaires</term>
<term>Enfant</term>
<term>Humains</term>
<term>Méthylation de l'ADN</term>
<term>Protéines de répression</term>
<term>Protéines proto-oncogènes</term>
<term>Régulation de l'expression des gènes tumoraux</term>
<term>Séquence d'acides aminés</term>
<term>Transduction du signal</term>
<term>Tumeurs du système nerveux central</term>
<term>Tumeurs neuroectodermiques</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>SUMMARY</title>
<p id="P2">Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly aggressive, poorly differentiated embryonal tumors occurring predominantly in young children but also affecting adolescents and adults. Herein we demonstrate that a significant proportion of institutionally diagnosed CNS-PNETs display molecular profiles indistinguishable from those of various other well-defined CNS tumor entities, facilitating diagnosis and appropriate therapy for patients with these tumors. From the remaining fraction of CNS-PNETs we identify four new CNS tumor entities, each associated with a recurrent genetic alteration and distinct histopathological and clinical features. These new molecular entities, designated “CNS neuroblastoma with <italic>FOXR2</italic>
activation (CNS NB-<italic>FOXR2</italic>
)”, “CNS Ewing sarcoma family tumor with <italic>CIC</italic>
alteration (CNS EFT-<italic>CIC</italic>
)”, “CNS high-grade neuroepithelial tumor with <italic>MN1</italic>
alteration (CNS HGNET-<italic>MN1</italic>
)”, and “CNS high-grade neuroepithelial tumor with <italic>BCOR</italic>
alteration (CNS HGNET-<italic>BCOR</italic>
)”, will enable meaningful clinical trials and the development of therapeutic strategies for patients affected by poorly differentiated CNS tumors.</p>
</div>
</front>
</TEI>
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<li>État de New York</li>
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</region>
<settlement><li>Amsterdam</li>
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<li>Düsseldorf</li>
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<li>Wurtzbourg</li>
<li>Zurich</li>
</settlement>
<orgName><li>Université Louis-et-Maximilien de Munich</li>
<li>Université d'Amsterdam</li>
<li>Université de Cambridge</li>
<li>Université de Toronto</li>
</orgName>
</list>
<tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Sturm, Dominik" sort="Sturm, Dominik" uniqKey="Sturm D" first="Dominik" last="Sturm">Dominik Sturm</name>
</region>
<name sortKey="Balasubramanian, Gnanaprakash" sort="Balasubramanian, Gnanaprakash" uniqKey="Balasubramanian G" first="Gnanaprakash" last="Balasubramanian">Gnanaprakash Balasubramanian</name>
<name sortKey="Brabetz, Sebastian" sort="Brabetz, Sebastian" uniqKey="Brabetz S" first="Sebastian" last="Brabetz">Sebastian Brabetz</name>
<name sortKey="Buchhalter, Ivo" sort="Buchhalter, Ivo" uniqKey="Buchhalter I" first="Ivo" last="Buchhalter">Ivo Buchhalter</name>
<name sortKey="Capper, David" sort="Capper, David" uniqKey="Capper D" first="David" last="Capper">David Capper</name>
<name sortKey="Ebinger, Martin" sort="Ebinger, Martin" uniqKey="Ebinger M" first="Martin" last="Ebinger">Martin Ebinger</name>
<name sortKey="Eils, Roland" sort="Eils, Roland" uniqKey="Eils R" first="Roland" last="Eils">Roland Eils</name>
<name sortKey="Eils, Roland" sort="Eils, Roland" uniqKey="Eils R" first="Roland" last="Eils">Roland Eils</name>
<name sortKey="Eils, Roland" sort="Eils, Roland" uniqKey="Eils R" first="Roland" last="Eils">Roland Eils</name>
<name sortKey="Felsberg, Jorg" sort="Felsberg, Jorg" uniqKey="Felsberg J" first="Jörg" last="Felsberg">Jörg Felsberg</name>
<name sortKey="Fruhwald, Michael C" sort="Fruhwald, Michael C" uniqKey="Fruhwald M" first="Michael C." last="Frühwald">Michael C. Frühwald</name>
<name sortKey="Hagel, Christian" sort="Hagel, Christian" uniqKey="Hagel C" first="Christian" last="Hagel">Christian Hagel</name>
<name sortKey="Hans, Volkmar" sort="Hans, Volkmar" uniqKey="Hans V" first="Volkmar" last="Hans">Volkmar Hans</name>
<name sortKey="Hasselblatt, Martin" sort="Hasselblatt, Martin" uniqKey="Hasselblatt M" first="Martin" last="Hasselblatt">Martin Hasselblatt</name>
<name sortKey="Herold Mende, Christel" sort="Herold Mende, Christel" uniqKey="Herold Mende C" first="Christel" last="Herold-Mende">Christel Herold-Mende</name>
<name sortKey="Hovestadt, Volker" sort="Hovestadt, Volker" uniqKey="Hovestadt V" first="Volker" last="Hovestadt">Volker Hovestadt</name>
<name sortKey="Johann, Pascal D" sort="Johann, Pascal D" uniqKey="Johann P" first="Pascal D." last="Johann">Pascal D. Johann</name>
<name sortKey="Johann, Pascal D" sort="Johann, Pascal D" uniqKey="Johann P" first="Pascal D." last="Johann">Pascal D. Johann</name>
<name sortKey="Jones, David T W" sort="Jones, David T W" uniqKey="Jones D" first="David T. W." last="Jones">David T. W. Jones</name>
<name sortKey="Koelsche, Christian" sort="Koelsche, Christian" uniqKey="Koelsche C" first="Christian" last="Koelsche">Christian Koelsche</name>
<name sortKey="Kool, Marcel" sort="Kool, Marcel" uniqKey="Kool M" first="Marcel" last="Kool">Marcel Kool</name>
<name sortKey="Korshunov, Andrey" sort="Korshunov, Andrey" uniqKey="Korshunov A" first="Andrey" last="Korshunov">Andrey Korshunov</name>
<name sortKey="Kramm, Christof M" sort="Kramm, Christof M" uniqKey="Kramm C" first="Christof M." last="Kramm">Christof M. Kramm</name>
<name sortKey="Leis, Irina" sort="Leis, Irina" uniqKey="Leis I" first="Irina" last="Leis">Irina Leis</name>
<name sortKey="Lichter, Peter" sort="Lichter, Peter" uniqKey="Lichter P" first="Peter" last="Lichter">Peter Lichter</name>
<name sortKey="Lichter, Peter" sort="Lichter, Peter" uniqKey="Lichter P" first="Peter" last="Lichter">Peter Lichter</name>
<name sortKey="Mawrin, Christian" sort="Mawrin, Christian" uniqKey="Mawrin C" first="Christian" last="Mawrin">Christian Mawrin</name>
<name sortKey="Milde, Till" sort="Milde, Till" uniqKey="Milde T" first="Till" last="Milde">Till Milde</name>
<name sortKey="Milde, Till" sort="Milde, Till" uniqKey="Milde T" first="Till" last="Milde">Till Milde</name>
<name sortKey="Monoranu, Camelia Maria" sort="Monoranu, Camelia Maria" uniqKey="Monoranu C" first="Camelia-Maria" last="Monoranu">Camelia-Maria Monoranu</name>
<name sortKey="Northcott, Paul A" sort="Northcott, Paul A" uniqKey="Northcott P" first="Paul A." last="Northcott">Paul A. Northcott</name>
<name sortKey="Pajtler, Kristian W" sort="Pajtler, Kristian W" uniqKey="Pajtler K" first="Kristian W." last="Pajtler">Kristian W. Pajtler</name>
<name sortKey="Pfaff, Elke" sort="Pfaff, Elke" uniqKey="Pfaff E" first="Elke" last="Pfaff">Elke Pfaff</name>
<name sortKey="Pfaff, Elke" sort="Pfaff, Elke" uniqKey="Pfaff E" first="Elke" last="Pfaff">Elke Pfaff</name>
<name sortKey="Pfister, Stefan M" sort="Pfister, Stefan M" uniqKey="Pfister S" first="Stefan M." last="Pfister">Stefan M. Pfister</name>
<name sortKey="Pfister, Stefan M" sort="Pfister, Stefan M" uniqKey="Pfister S" first="Stefan M." last="Pfister">Stefan M. Pfister</name>
<name sortKey="Pietsch, Torsten" sort="Pietsch, Torsten" uniqKey="Pietsch T" first="Torsten" last="Pietsch">Torsten Pietsch</name>
<name sortKey="Prinz, Marco" sort="Prinz, Marco" uniqKey="Prinz M" first="Marco" last="Prinz">Marco Prinz</name>
<name sortKey="Reifenberger, Guido" sort="Reifenberger, Guido" uniqKey="Reifenberger G" first="Guido" last="Reifenberger">Guido Reifenberger</name>
<name sortKey="Ro Ler, Jochen" sort="Ro Ler, Jochen" uniqKey="Ro Ler J" first="Jochen" last="Rö Ler">Jochen Rö Ler</name>
<name sortKey="Rutkowski, Stefan" sort="Rutkowski, Stefan" uniqKey="Rutkowski S" first="Stefan" last="Rutkowski">Stefan Rutkowski</name>
<name sortKey="Sahm, Felix" sort="Sahm, Felix" uniqKey="Sahm F" first="Felix" last="Sahm">Felix Sahm</name>
<name sortKey="Scheurlen, Wolfram" sort="Scheurlen, Wolfram" uniqKey="Scheurlen W" first="Wolfram" last="Scheurlen">Wolfram Scheurlen</name>
<name sortKey="Schittenhelm, Jens" sort="Schittenhelm, Jens" uniqKey="Schittenhelm J" first="Jens" last="Schittenhelm">Jens Schittenhelm</name>
<name sortKey="Schlesner, Matthias" sort="Schlesner, Matthias" uniqKey="Schlesner M" first="Matthias" last="Schlesner">Matthias Schlesner</name>
<name sortKey="Schneppenheim, Reinhard" sort="Schneppenheim, Reinhard" uniqKey="Schneppenheim R" first="Reinhard" last="Schneppenheim">Reinhard Schneppenheim</name>
<name sortKey="Schuhmann, Martin U" sort="Schuhmann, Martin U" uniqKey="Schuhmann M" first="Martin U." last="Schuhmann">Martin U. Schuhmann</name>
<name sortKey="Schuller, Ulrich" sort="Schuller, Ulrich" uniqKey="Schuller U" first="Ulrich" last="Schüller">Ulrich Schüller</name>
<name sortKey="Sill, Martin" sort="Sill, Martin" uniqKey="Sill M" first="Martin" last="Sill">Martin Sill</name>
<name sortKey="Sturm, Dominik" sort="Sturm, Dominik" uniqKey="Sturm D" first="Dominik" last="Sturm">Dominik Sturm</name>
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<name sortKey="Worst, Barbara C" sort="Worst, Barbara C" uniqKey="Worst B" first="Barbara C." last="Worst">Barbara C. Worst</name>
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<country name="États-Unis"><region name="Tennessee"><name sortKey="Orr, Brent A" sort="Orr, Brent A" uniqKey="Orr B" first="Brent A." last="Orr">Brent A. Orr</name>
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<name sortKey="Aldape, Kenneth" sort="Aldape, Kenneth" uniqKey="Aldape K" first="Kenneth" last="Aldape">Kenneth Aldape</name>
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<name sortKey="Cowdrey, Cynthia" sort="Cowdrey, Cynthia" uniqKey="Cowdrey C" first="Cynthia" last="Cowdrey">Cynthia Cowdrey</name>
<name sortKey="Dahiya, Sonika" sort="Dahiya, Sonika" uniqKey="Dahiya S" first="Sonika" last="Dahiya">Sonika Dahiya</name>
<name sortKey="Drissi, Rachid" sort="Drissi, Rachid" uniqKey="Drissi R" first="Rachid" last="Drissi">Rachid Drissi</name>
<name sortKey="Ellison, David W" sort="Ellison, David W" uniqKey="Ellison D" first="David W." last="Ellison">David W. Ellison</name>
<name sortKey="Forrester, Lynn Ann" sort="Forrester, Lynn Ann" uniqKey="Forrester L" first="Lynn Ann" last="Forrester">Lynn Ann Forrester</name>
<name sortKey="Fouladi, Maryam" sort="Fouladi, Maryam" uniqKey="Fouladi M" first="Maryam" last="Fouladi">Maryam Fouladi</name>
<name sortKey="Gajjar, Amar" sort="Gajjar, Amar" uniqKey="Gajjar A" first="Amar" last="Gajjar">Amar Gajjar</name>
<name sortKey="Karajannis, Matthias A" sort="Karajannis, Matthias A" uniqKey="Karajannis M" first="Matthias A." last="Karajannis">Matthias A. Karajannis</name>
<name sortKey="Mikkelsen, Tom" sort="Mikkelsen, Tom" uniqKey="Mikkelsen T" first="Tom" last="Mikkelsen">Tom Mikkelsen</name>
<name sortKey="Mobley, Bret C" sort="Mobley, Bret C" uniqKey="Mobley B" first="Bret C." last="Mobley">Bret C. Mobley</name>
<name sortKey="Perry, Arie" sort="Perry, Arie" uniqKey="Perry A" first="Arie" last="Perry">Arie Perry</name>
<name sortKey="Perry, Arie" sort="Perry, Arie" uniqKey="Perry A" first="Arie" last="Perry">Arie Perry</name>
<name sortKey="Perry, Arie" sort="Perry, Arie" uniqKey="Perry A" first="Arie" last="Perry">Arie Perry</name>
<name sortKey="Phillips, Joanna J" sort="Phillips, Joanna J" uniqKey="Phillips J" first="Joanna J." last="Phillips">Joanna J. Phillips</name>
<name sortKey="Phillips, Joanna J" sort="Phillips, Joanna J" uniqKey="Phillips J" first="Joanna J." last="Phillips">Joanna J. Phillips</name>
<name sortKey="Phillips, Joanna J" sort="Phillips, Joanna J" uniqKey="Phillips J" first="Joanna J." last="Phillips">Joanna J. Phillips</name>
<name sortKey="Santi, Mariarita" sort="Santi, Mariarita" uniqKey="Santi M" first="Mariarita" last="Santi">Mariarita Santi</name>
<name sortKey="Schniederjan, Matthew J" sort="Schniederjan, Matthew J" uniqKey="Schniederjan M" first="Matthew J." last="Schniederjan">Matthew J. Schniederjan</name>
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<name sortKey="Van Meter, Timothy" sort="Van Meter, Timothy" uniqKey="Van Meter T" first="Timothy" last="Van Meter">Timothy Van Meter</name>
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<country name="Russie"><region name="District fédéral central"><name sortKey="Ryzhova, Marina" sort="Ryzhova, Marina" uniqKey="Ryzhova M" first="Marina" last="Ryzhova">Marina Ryzhova</name>
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</country>
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</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Mackay, Alan" sort="Mackay, Alan" uniqKey="Mackay A" first="Alan" last="Mackay">Alan Mackay</name>
</region>
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<name sortKey="Jones, Chris" sort="Jones, Chris" uniqKey="Jones C" first="Chris" last="Jones">Chris Jones</name>
</country>
<country name="Italie"><region name="Latium"><name sortKey="Giangaspero, Felice" sort="Giangaspero, Felice" uniqKey="Giangaspero F" first="Felice" last="Giangaspero">Felice Giangaspero</name>
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<name sortKey="Buccoliero, Anna M" sort="Buccoliero, Anna M" uniqKey="Buccoliero A" first="Anna M." last="Buccoliero">Anna M. Buccoliero</name>
<name sortKey="Giangaspero, Felice" sort="Giangaspero, Felice" uniqKey="Giangaspero F" first="Felice" last="Giangaspero">Felice Giangaspero</name>
</country>
<country name="Pologne"><noRegion><name sortKey="Lastowska, Maria" sort="Lastowska, Maria" uniqKey="Lastowska M" first="Maria" last="Łastowska">Maria Łastowska</name>
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<name sortKey="Gojo, Johannes" sort="Gojo, Johannes" uniqKey="Gojo J" first="Johannes" last="Gojo">Johannes Gojo</name>
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<country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Jouvet, Anne" sort="Jouvet, Anne" uniqKey="Jouvet A" first="Anne" last="Jouvet">Anne Jouvet</name>
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<country name="Suède"><noRegion><name sortKey="Holm, Stefan" sort="Holm, Stefan" uniqKey="Holm S" first="Stefan" last="Holm">Stefan Holm</name>
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</country>
<country name="Suisse"><noRegion><name sortKey="Hofer, Silvia" sort="Hofer, Silvia" uniqKey="Hofer S" first="Silvia" last="Hofer">Silvia Hofer</name>
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<name sortKey="Frank, Stephan" sort="Frank, Stephan" uniqKey="Frank S" first="Stephan" last="Frank">Stephan Frank</name>
<name sortKey="Grobholz, Rainer" sort="Grobholz, Rainer" uniqKey="Grobholz R" first="Rainer" last="Grobholz">Rainer Grobholz</name>
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<name sortKey="Vajtai, Istvan" sort="Vajtai, Istvan" uniqKey="Vajtai I" first="Istvan" last="Vajtai">Istvan Vajtai</name>
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<country name="Irlande (pays)"><noRegion><name sortKey="Keohane, Catherine" sort="Keohane, Catherine" uniqKey="Keohane C" first="Catherine" last="Keohane">Catherine Keohane</name>
</noRegion>
</country>
<country name="Israël"><noRegion><name sortKey="Fried, Iris" sort="Fried, Iris" uniqKey="Fried I" first="Iris" last="Fried">Iris Fried</name>
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</country>
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</country>
<country name="Pays-Bas"><noRegion><name sortKey="Wesseling, Pieter" sort="Wesseling, Pieter" uniqKey="Wesseling P" first="Pieter" last="Wesseling">Pieter Wesseling</name>
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<name sortKey="Aronica, Eleonora" sort="Aronica, Eleonora" uniqKey="Aronica E" first="Eleonora" last="Aronica">Eleonora Aronica</name>
<name sortKey="Koster, Jan" sort="Koster, Jan" uniqKey="Koster J" first="Jan" last="Koster">Jan Koster</name>
<name sortKey="Van Sluis, Peter" sort="Van Sluis, Peter" uniqKey="Van Sluis P" first="Peter" last="Van Sluis">Peter Van Sluis</name>
<name sortKey="Versteeg, Rogier" sort="Versteeg, Rogier" uniqKey="Versteeg R" first="Rogier" last="Versteeg">Rogier Versteeg</name>
<name sortKey="Volckmann, Richard" sort="Volckmann, Richard" uniqKey="Volckmann R" first="Richard" last="Volckmann">Richard Volckmann</name>
<name sortKey="Wesseling, Pieter" sort="Wesseling, Pieter" uniqKey="Wesseling P" first="Pieter" last="Wesseling">Pieter Wesseling</name>
</country>
<country name="République tchèque"><noRegion><name sortKey="Zitterbart, Karel" sort="Zitterbart, Karel" uniqKey="Zitterbart K" first="Karel" last="Zitterbart">Karel Zitterbart</name>
</noRegion>
</country>
<country name="Australie"><noRegion><name sortKey="Moore, Andrew S" sort="Moore, Andrew S" uniqKey="Moore A" first="Andrew S." last="Moore">Andrew S. Moore</name>
</noRegion>
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</tree>
</affiliations>
</record>
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