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New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

Identifieur interne : 001A51 ( Main/Exploration ); précédent : 001A50; suivant : 001A52

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

Auteurs : Dominik Sturm [Allemagne] ; Brent A. Orr [États-Unis] ; Umut H. Toprak [Allemagne] ; Volker Hovestadt [Allemagne] ; David T. W. Jones [Allemagne] ; David Capper [Allemagne] ; Martin Sill [Allemagne] ; Ivo Buchhalter [Allemagne] ; Paul A. Northcott [Allemagne] ; Irina Leis [Allemagne] ; Marina Ryzhova [Russie] ; Christian Koelsche [Allemagne] ; Elke Pfaff [Allemagne] ; Sariah J. Allen [États-Unis] ; Gnanaprakash Balasubramanian [Allemagne] ; Barbara C. Worst [Allemagne] ; Kristian W. Pajtler [Allemagne] ; Sebastian Brabetz [Allemagne] ; Pascal D. Johann [Allemagne] ; Felix Sahm [Allemagne] ; Jüri Reimand [Canada] ; Alan Mackay [Royaume-Uni] ; Diana M. Carvalho [Royaume-Uni] ; Marc Remke [Canada] ; Joanna J. Phillips [États-Unis] ; Arie Perry [États-Unis] ; Cynthia Cowdrey [États-Unis] ; Rachid Drissi [États-Unis] ; Maryam Fouladi [États-Unis] ; Felice Giangaspero [Italie] ; Maria Łastowska [Pologne] ; Wiesława Grajkowska [Pologne] ; Wolfram Scheurlen [Allemagne] ; Torsten Pietsch [Allemagne] ; Christian Hagel [Allemagne] ; Johannes Gojo [Autriche] ; Daniela Lötsch [Autriche] ; Walter Berger [Autriche] ; Irene Slavc [Autriche] ; Christine Haberler [Autriche] ; Anne Jouvet [France] ; Stefan Holm [Suède] ; Silvia Hofer [Suisse] ; Marco Prinz [Allemagne] ; Catherine Keohane [Irlande (pays)] ; Iris Fried [Israël] ; Christian Mawrin [Allemagne] ; David Scheie [Danemark] ; Bret C. Mobley [États-Unis] ; Matthew J. Schniederjan [États-Unis] ; Mariarita Santi [États-Unis] ; Anna M. Buccoliero [Italie] ; Sonika Dahiya [États-Unis] ; Christof M. Kramm [Allemagne] ; André O. Von Bueren [Allemagne] ; Katja Von Hoff [Allemagne] ; Stefan Rutkowski [Allemagne] ; Christel Herold-Mende [Allemagne] ; Michael C. Frühwald [Allemagne] ; Till Milde [Allemagne] ; Martin Hasselblatt [Allemagne] ; Pieter Wesseling [Pays-Bas] ; Jochen Rö Ler [Allemagne] ; Ulrich Schüller [Allemagne] ; Martin Ebinger [Allemagne] ; Jens Schittenhelm [Allemagne] ; Stephan Frank [Suisse] ; Rainer Grobholz [Suisse] ; Istvan Vajtai [Suisse] ; Volkmar Hans [Allemagne] ; Reinhard Schneppenheim [Allemagne] ; Karel Zitterbart [République tchèque] ; V. Peter Collins [Royaume-Uni] ; Eleonora Aronica [Pays-Bas] ; Pascale Varlet [France] ; Stephanie Puget [France] ; Christelle Dufour [France] ; Jacques Grill [France] ; Dominique Figarella-Branger [France] ; Marietta Wolter [Allemagne] ; Martin U. Schuhmann [Allemagne] ; Tarek Shalaby [Suisse] ; Michael Grotzer [Suisse] ; Timothy Van Meter [États-Unis] ; Camelia-Maria Monoranu [Allemagne] ; Jörg Felsberg [Allemagne] ; Guido Reifenberger [Allemagne] ; Matija Snuderl [États-Unis] ; Lynn Ann Forrester [États-Unis] ; Jan Koster [Pays-Bas] ; Rogier Versteeg [Pays-Bas] ; Richard Volckmann [Pays-Bas] ; Peter Van Sluis [Pays-Bas] ; Stephan Wolf [Allemagne] ; Tom Mikkelsen [États-Unis] ; Amar Gajjar [États-Unis] ; Kenneth Aldape [États-Unis] ; Andrew S. Moore [Australie] ; Michael D. Taylor [Canada] ; Chris Jones [Royaume-Uni] ; Nada Jabado [Canada] ; Matthias A. Karajannis [États-Unis] ; Roland Eils [Allemagne] ; Matthias Schlesner [Allemagne] ; Peter Lichter [Allemagne] ; Andreas Von Deimling [Allemagne] ; Stefan M. Pfister [Allemagne] ; David W. Ellison [États-Unis] ; Andrey Korshunov [Allemagne] ; Marcel Kool [Allemagne]

Source :

RBID : PMC:5139621

Descripteurs français

English descriptors

Abstract

SUMMARY

Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly aggressive, poorly differentiated embryonal tumors occurring predominantly in young children but also affecting adolescents and adults. Herein we demonstrate that a significant proportion of institutionally diagnosed CNS-PNETs display molecular profiles indistinguishable from those of various other well-defined CNS tumor entities, facilitating diagnosis and appropriate therapy for patients with these tumors. From the remaining fraction of CNS-PNETs we identify four new CNS tumor entities, each associated with a recurrent genetic alteration and distinct histopathological and clinical features. These new molecular entities, designated “CNS neuroblastoma with FOXR2 activation (CNS NB-FOXR2)”, “CNS Ewing sarcoma family tumor with CIC alteration (CNS EFT-CIC)”, “CNS high-grade neuroepithelial tumor with MN1 alteration (CNS HGNET-MN1)”, and “CNS high-grade neuroepithelial tumor with BCOR alteration (CNS HGNET-BCOR)”, will enable meaningful clinical trials and the development of therapeutic strategies for patients affected by poorly differentiated CNS tumors.


Url:
DOI: 10.1016/j.cell.2016.01.015
PubMed: 26919435
PubMed Central: 5139621


Affiliations:


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<nlm:aff id="A11"> Ontario Institute for Cancer Research, M5G 0A3, Toronto, ON M5G 1L7, Canada.</nlm:aff>
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<nlm:aff id="A12"> Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.</nlm:aff>
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<orgName type="university">Université de Toronto</orgName>
<placeName>
<settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Mackay, Alan" sort="Mackay, Alan" uniqKey="Mackay A" first="Alan" last="Mackay">Alan Mackay</name>
<affiliation wicri:level="3">
<nlm:aff id="A13"> Division of Molecular Pathology, The Institute of Cancer Research, SW7 3RP, London, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea> Division of Molecular Pathology, The Institute of Cancer Research, SW7 3RP, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Carvalho, Diana M" sort="Carvalho, Diana M" uniqKey="Carvalho D" first="Diana M." last="Carvalho">Diana M. Carvalho</name>
<affiliation wicri:level="3">
<nlm:aff id="A13"> Division of Molecular Pathology, The Institute of Cancer Research, SW7 3RP, London, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea> Division of Molecular Pathology, The Institute of Cancer Research, SW7 3RP, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Remke, Marc" sort="Remke, Marc" uniqKey="Remke M" first="Marc" last="Remke">Marc Remke</name>
<affiliation wicri:level="4">
<nlm:aff id="A14"> Program in Developmental and Stem Cell Biology, Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Toronto, ON M4N 1X8, Canada.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Canada</country>
<wicri:regionArea> Program in Developmental and Stem Cell Biology, Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Toronto, ON M4N 1X8</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName>
<settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Phillips, Joanna J" sort="Phillips, Joanna J" uniqKey="Phillips J" first="Joanna J." last="Phillips">Joanna J. Phillips</name>
<affiliation wicri:level="2">
<nlm:aff id="A15"> Brain Tumor Research Center, University of California, San Francisco, CA 94158-9001, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Brain Tumor Research Center, University of California, San Francisco, CA 94158-9001</wicri:regionArea>
<placeName>
<region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A16"> Neuropathology, Department of Pathology, University of California, San Francisco, CA 94143-0102, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Neuropathology, Department of Pathology, University of California, San Francisco, CA 94143-0102</wicri:regionArea>
<placeName>
<region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A17"> Department of Neurological Surgery, University of California, San Francisco, CA 94143-0112, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurological Surgery, University of California, San Francisco, CA 94143-0112</wicri:regionArea>
<placeName>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Perry, Arie" sort="Perry, Arie" uniqKey="Perry A" first="Arie" last="Perry">Arie Perry</name>
<affiliation wicri:level="2">
<nlm:aff id="A15"> Brain Tumor Research Center, University of California, San Francisco, CA 94158-9001, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Brain Tumor Research Center, University of California, San Francisco, CA 94158-9001</wicri:regionArea>
<placeName>
<region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A16"> Neuropathology, Department of Pathology, University of California, San Francisco, CA 94143-0102, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Neuropathology, Department of Pathology, University of California, San Francisco, CA 94143-0102</wicri:regionArea>
<placeName>
<region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A17"> Department of Neurological Surgery, University of California, San Francisco, CA 94143-0112, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurological Surgery, University of California, San Francisco, CA 94143-0112</wicri:regionArea>
<placeName>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Cowdrey, Cynthia" sort="Cowdrey, Cynthia" uniqKey="Cowdrey C" first="Cynthia" last="Cowdrey">Cynthia Cowdrey</name>
<affiliation wicri:level="2">
<nlm:aff id="A15"> Brain Tumor Research Center, University of California, San Francisco, CA 94158-9001, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Brain Tumor Research Center, University of California, San Francisco, CA 94158-9001</wicri:regionArea>
<placeName>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Drissi, Rachid" sort="Drissi, Rachid" uniqKey="Drissi R" first="Rachid" last="Drissi">Rachid Drissi</name>
<affiliation wicri:level="2">
<nlm:aff id="A18"> Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229</wicri:regionArea>
<placeName>
<region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Fouladi, Maryam" sort="Fouladi, Maryam" uniqKey="Fouladi M" first="Maryam" last="Fouladi">Maryam Fouladi</name>
<affiliation wicri:level="2">
<nlm:aff id="A18"> Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229</wicri:regionArea>
<placeName>
<region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Giangaspero, Felice" sort="Giangaspero, Felice" uniqKey="Giangaspero F" first="Felice" last="Giangaspero">Felice Giangaspero</name>
<affiliation wicri:level="1">
<nlm:aff id="A19"> Department of Radiological, Oncological and Anatomic-Pathological Sciences, Sapienza University of Rome, 00185 Rome, Italy.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Italie</country>
<wicri:regionArea> Department of Radiological, Oncological and Anatomic-Pathological Sciences, Sapienza University of Rome, 00185 Rome</wicri:regionArea>
<placeName>
<settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A20"> IRCCS Neuromed, 86077 Pozzilli, Molise, Italy.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Italie</country>
<wicri:regionArea> IRCCS Neuromed, 86077 Pozzilli, Molise</wicri:regionArea>
<wicri:noRegion>Molise</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Lastowska, Maria" sort="Lastowska, Maria" uniqKey="Lastowska M" first="Maria" last="Łastowska">Maria Łastowska</name>
<affiliation wicri:level="1">
<nlm:aff id="A21"> Department of Pathology, Children's Memorial Health Institute, 04-730 Warsaw, Poland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pologne</country>
<wicri:regionArea> Department of Pathology, Children's Memorial Health Institute, 04-730 Warsaw</wicri:regionArea>
<wicri:noRegion>04-730 Warsaw</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Grajkowska, Wieslawa" sort="Grajkowska, Wieslawa" uniqKey="Grajkowska W" first="Wiesława" last="Grajkowska">Wiesława Grajkowska</name>
<affiliation wicri:level="1">
<nlm:aff id="A21"> Department of Pathology, Children's Memorial Health Institute, 04-730 Warsaw, Poland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pologne</country>
<wicri:regionArea> Department of Pathology, Children's Memorial Health Institute, 04-730 Warsaw</wicri:regionArea>
<wicri:noRegion>04-730 Warsaw</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Scheurlen, Wolfram" sort="Scheurlen, Wolfram" uniqKey="Scheurlen W" first="Wolfram" last="Scheurlen">Wolfram Scheurlen</name>
<affiliation wicri:level="1">
<nlm:aff id="A22"> Cnopf'sche Kinderklinik, Nürnberg Children's Hospital, 90419 Nürnberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Cnopf'sche Kinderklinik, Nürnberg Children's Hospital, 90419 Nürnberg</wicri:regionArea>
<wicri:noRegion>90419 Nürnberg</wicri:noRegion>
<wicri:noRegion>90419 Nürnberg</wicri:noRegion>
<wicri:noRegion>90419 Nürnberg</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Pietsch, Torsten" sort="Pietsch, Torsten" uniqKey="Pietsch T" first="Torsten" last="Pietsch">Torsten Pietsch</name>
<affiliation wicri:level="1">
<nlm:aff id="A23"> Department of Neuropathology, University of Bonn Medical School, 53105 Bonn, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, University of Bonn Medical School, 53105 Bonn</wicri:regionArea>
<wicri:noRegion>53105 Bonn</wicri:noRegion>
<placeName>
<settlement type="city">Bonn</settlement>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hagel, Christian" sort="Hagel, Christian" uniqKey="Hagel C" first="Christian" last="Hagel">Christian Hagel</name>
<affiliation wicri:level="1">
<nlm:aff id="A24"> Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg</wicri:regionArea>
<wicri:noRegion>20246 Hamburg</wicri:noRegion>
<placeName>
<settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Gojo, Johannes" sort="Gojo, Johannes" uniqKey="Gojo J" first="Johannes" last="Gojo">Johannes Gojo</name>
<affiliation wicri:level="3">
<nlm:aff id="A25"> Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, 1090 Vienna, Austria.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Autriche</country>
<wicri:regionArea> Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, 1090 Vienna</wicri:regionArea>
<placeName>
<region type="land" nuts="2">Vienne (Autriche)</region>
<settlement type="city">Vienne (Autriche)</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A26"> Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Autriche</country>
<wicri:regionArea> Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna</wicri:regionArea>
<placeName>
<region type="land" nuts="2">Vienne (Autriche)</region>
<settlement type="city">Vienne (Autriche)</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Lotsch, Daniela" sort="Lotsch, Daniela" uniqKey="Lotsch D" first="Daniela" last="Lötsch">Daniela Lötsch</name>
<affiliation wicri:level="3">
<nlm:aff id="A26"> Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Autriche</country>
<wicri:regionArea> Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna</wicri:regionArea>
<placeName>
<region type="land" nuts="2">Vienne (Autriche)</region>
<settlement type="city">Vienne (Autriche)</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Berger, Walter" sort="Berger, Walter" uniqKey="Berger W" first="Walter" last="Berger">Walter Berger</name>
<affiliation wicri:level="3">
<nlm:aff id="A26"> Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Autriche</country>
<wicri:regionArea> Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna</wicri:regionArea>
<placeName>
<region type="land" nuts="2">Vienne (Autriche)</region>
<settlement type="city">Vienne (Autriche)</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Slavc, Irene" sort="Slavc, Irene" uniqKey="Slavc I" first="Irene" last="Slavc">Irene Slavc</name>
<affiliation wicri:level="3">
<nlm:aff id="A25"> Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, 1090 Vienna, Austria.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Autriche</country>
<wicri:regionArea> Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, 1090 Vienna</wicri:regionArea>
<placeName>
<region type="land" nuts="2">Vienne (Autriche)</region>
<settlement type="city">Vienne (Autriche)</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Haberler, Christine" sort="Haberler, Christine" uniqKey="Haberler C" first="Christine" last="Haberler">Christine Haberler</name>
<affiliation wicri:level="3">
<nlm:aff id="A27"> Institute of Neurology, Medical University of Vienna, 1097 Vienna, Austria.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Autriche</country>
<wicri:regionArea> Institute of Neurology, Medical University of Vienna, 1097 Vienna</wicri:regionArea>
<placeName>
<region type="land" nuts="2">Vienne (Autriche)</region>
<settlement type="city">Vienne (Autriche)</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Jouvet, Anne" sort="Jouvet, Anne" uniqKey="Jouvet A" first="Anne" last="Jouvet">Anne Jouvet</name>
<affiliation wicri:level="1">
<nlm:aff id="A28"> Neuro-Oncology and Neuro-Inflammation Team, Inserm U1028, CNRS UMR 5292, University Lyon-1, Neuroscience Center, 69000 Lyon, France, and Centre de Pathologie et de Neuropathologie Est, Hospices Civils de Lyon, 69003 Lyon, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea> Neuro-Oncology and Neuro-Inflammation Team, Inserm U1028, CNRS UMR 5292, University Lyon-1, Neuroscience Center, 69000 Lyon, France, and Centre de Pathologie et de Neuropathologie Est, Hospices Civils de Lyon, 69003 Lyon</wicri:regionArea>
<wicri:noRegion>69003 Lyon</wicri:noRegion>
<placeName>
<settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Holm, Stefan" sort="Holm, Stefan" uniqKey="Holm S" first="Stefan" last="Holm">Stefan Holm</name>
<affiliation wicri:level="1">
<nlm:aff id="A29"> Department of Women's and Children's Health (KBH), Karolinska Institutet, SE-171 77 Stockholm, Sweden.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Suède</country>
<wicri:regionArea> Department of Women's and Children's Health (KBH), Karolinska Institutet, SE-171 77 Stockholm</wicri:regionArea>
<wicri:noRegion>SE-171 77 Stockholm</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hofer, Silvia" sort="Hofer, Silvia" uniqKey="Hofer S" first="Silvia" last="Hofer">Silvia Hofer</name>
<affiliation wicri:level="1">
<nlm:aff id="A30"> Department of Oncology, Luzerner Kantonsspital, 6000 Luzern 16, Luzern, Switzerland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Suisse</country>
<wicri:regionArea> Department of Oncology, Luzerner Kantonsspital, 6000 Luzern 16, Luzern</wicri:regionArea>
<wicri:noRegion>Luzern</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Prinz, Marco" sort="Prinz, Marco" uniqKey="Prinz M" first="Marco" last="Prinz">Marco Prinz</name>
<affiliation wicri:level="3">
<nlm:aff id="A31"> Institute of Neuropathology, University of Freiburg, Germany & BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79106 Freiburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Institute of Neuropathology, University of Freiburg, Germany & BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79106 Freiburg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Fribourg-en-Brisgau</region>
<settlement type="city">Fribourg-en-Brisgau</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Keohane, Catherine" sort="Keohane, Catherine" uniqKey="Keohane C" first="Catherine" last="Keohane">Catherine Keohane</name>
<affiliation wicri:level="1">
<nlm:aff id="A32"> Department of Pathology, University College Cork and Cork University Hospital Wilton, Cork, Ireland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Irlande (pays)</country>
<wicri:regionArea> Department of Pathology, University College Cork and Cork University Hospital Wilton, Cork</wicri:regionArea>
<wicri:noRegion>Cork</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Fried, Iris" sort="Fried, Iris" uniqKey="Fried I" first="Iris" last="Fried">Iris Fried</name>
<affiliation wicri:level="1">
<nlm:aff id="A33"> Department of Pediatric Hematology and Oncology, Hadassah Medical Center, Jerusalem, Israel.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Israël</country>
<wicri:regionArea> Department of Pediatric Hematology and Oncology, Hadassah Medical Center, Jerusalem</wicri:regionArea>
<wicri:noRegion>Jerusalem</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Mawrin, Christian" sort="Mawrin, Christian" uniqKey="Mawrin C" first="Christian" last="Mawrin">Christian Mawrin</name>
<affiliation wicri:level="3">
<nlm:aff id="A34"> Institute of Neuropathology, University Hospital, Otto-von-Guericke University, 39120 Magdeburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Institute of Neuropathology, University Hospital, Otto-von-Guericke University, 39120 Magdeburg</wicri:regionArea>
<placeName>
<region type="land" nuts="2">Saxe-Anhalt</region>
<settlement type="city">Magdebourg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Scheie, David" sort="Scheie, David" uniqKey="Scheie D" first="David" last="Scheie">David Scheie</name>
<affiliation wicri:level="1">
<nlm:aff id="A35"> Department of Pathology, Copenhagen University Hospital, 2100 København Ø, Denmark.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Danemark</country>
<wicri:regionArea> Department of Pathology, Copenhagen University Hospital, 2100 København Ø</wicri:regionArea>
<wicri:noRegion>2100 København Ø</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Mobley, Bret C" sort="Mobley, Bret C" uniqKey="Mobley B" first="Bret C." last="Mobley">Bret C. Mobley</name>
<affiliation wicri:level="2">
<nlm:aff id="A36"> Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232</wicri:regionArea>
<placeName>
<region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Schniederjan, Matthew J" sort="Schniederjan, Matthew J" uniqKey="Schniederjan M" first="Matthew J." last="Schniederjan">Matthew J. Schniederjan</name>
<affiliation wicri:level="2">
<nlm:aff id="A37"> Department of Pathology and Laboratory Administration, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Pathology and Laboratory Administration, Children's Healthcare of Atlanta, Atlanta, GA 30322</wicri:regionArea>
<placeName>
<region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Santi, Mariarita" sort="Santi, Mariarita" uniqKey="Santi M" first="Mariarita" last="Santi">Mariarita Santi</name>
<affiliation wicri:level="2">
<nlm:aff id="A38"> Department of Pathology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Pathology, Children's Hospital of Philadelphia, Philadelphia, PA 19104</wicri:regionArea>
<placeName>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Buccoliero, Anna M" sort="Buccoliero, Anna M" uniqKey="Buccoliero A" first="Anna M." last="Buccoliero">Anna M. Buccoliero</name>
<affiliation wicri:level="1">
<nlm:aff id="A39"> Pathology Unit, Anna Meyer Children's University Hospital, 50141 Florence, Italy.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Italie</country>
<wicri:regionArea> Pathology Unit, Anna Meyer Children's University Hospital, 50141 Florence</wicri:regionArea>
<wicri:noRegion>50141 Florence</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Dahiya, Sonika" sort="Dahiya, Sonika" uniqKey="Dahiya S" first="Sonika" last="Dahiya">Sonika Dahiya</name>
<affiliation wicri:level="2">
<nlm:aff id="A40"> Department of Pathology and Immunology, Washington University, St. Louis, MO 63110, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Pathology and Immunology, Washington University, St. Louis, MO 63110</wicri:regionArea>
<placeName>
<region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kramm, Christof M" sort="Kramm, Christof M" uniqKey="Kramm C" first="Christof M." last="Kramm">Christof M. Kramm</name>
<affiliation wicri:level="3">
<nlm:aff id="A41"> Division of Pediatric Hematology and Oncology, Department of Child and Adolescent Health, University Medical Center Göttingen, 37075 Göttingen, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Hematology and Oncology, Department of Child and Adolescent Health, University Medical Center Göttingen, 37075 Göttingen</wicri:regionArea>
<placeName>
<region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Göttingen</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Von Bueren, Andre O" sort="Von Bueren, Andre O" uniqKey="Von Bueren A" first="André O." last="Von Bueren">André O. Von Bueren</name>
<affiliation wicri:level="3">
<nlm:aff id="A41"> Division of Pediatric Hematology and Oncology, Department of Child and Adolescent Health, University Medical Center Göttingen, 37075 Göttingen, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Hematology and Oncology, Department of Child and Adolescent Health, University Medical Center Göttingen, 37075 Göttingen</wicri:regionArea>
<placeName>
<region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Göttingen</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Von Hoff, Katja" sort="Von Hoff, Katja" uniqKey="Von Hoff K" first="Katja" last="Von Hoff">Katja Von Hoff</name>
<affiliation wicri:level="1">
<nlm:aff id="A42"> Department of Pediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg</wicri:regionArea>
<wicri:noRegion>20246 Hamburg</wicri:noRegion>
<placeName>
<settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Rutkowski, Stefan" sort="Rutkowski, Stefan" uniqKey="Rutkowski S" first="Stefan" last="Rutkowski">Stefan Rutkowski</name>
<affiliation wicri:level="1">
<nlm:aff id="A42"> Department of Pediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg</wicri:regionArea>
<wicri:noRegion>20246 Hamburg</wicri:noRegion>
<placeName>
<settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Herold Mende, Christel" sort="Herold Mende, Christel" uniqKey="Herold Mende C" first="Christel" last="Herold-Mende">Christel Herold-Mende</name>
<affiliation wicri:level="3">
<nlm:aff id="A43"> Department of Neurosurgery, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neurosurgery, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Fruhwald, Michael C" sort="Fruhwald, Michael C" uniqKey="Fruhwald M" first="Michael C." last="Frühwald">Michael C. Frühwald</name>
<affiliation wicri:level="3">
<nlm:aff id="A44"> Pediatric Hospital, Klinikum Augsburg, 86156 Augsburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Pediatric Hospital, Klinikum Augsburg, 86156 Augsburg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Souabe</region>
<settlement type="city">Augsbourg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Milde, Till" sort="Milde, Till" uniqKey="Milde T" first="Till" last="Milde">Till Milde</name>
<affiliation wicri:level="3">
<nlm:aff id="A2"> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A45"> Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hasselblatt, Martin" sort="Hasselblatt, Martin" uniqKey="Hasselblatt M" first="Martin" last="Hasselblatt">Martin Hasselblatt</name>
<affiliation wicri:level="3">
<nlm:aff id="A46"> Institute of Neuropathology, University Hospital Münster, 48149 Münster, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Institute of Neuropathology, University Hospital Münster, 48149 Münster</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Münster</region>
<settlement type="city">Münster</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Wesseling, Pieter" sort="Wesseling, Pieter" uniqKey="Wesseling P" first="Pieter" last="Wesseling">Pieter Wesseling</name>
<affiliation wicri:level="1">
<nlm:aff id="A47"> Department of Pathology, VU University Medical Center Amsterdam, 1008 MB Amsterdam, The Netherlands.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea> Department of Pathology, VU University Medical Center Amsterdam, 1008 MB Amsterdam</wicri:regionArea>
<wicri:noRegion>1008 MB Amsterdam</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A48"> Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, 6525 GA, The Netherlands.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea> Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, 6525 GA</wicri:regionArea>
<wicri:noRegion>6525 GA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Ro Ler, Jochen" sort="Ro Ler, Jochen" uniqKey="Ro Ler J" first="Jochen" last="Rö Ler">Jochen Rö Ler</name>
<affiliation wicri:level="3">
<nlm:aff id="A49"> Department of Pediatric Hematology/Oncology, Center of Pediatrics and Adolescent Medicine, University Medical Center Freiburg, 79106 Freiburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Hematology/Oncology, Center of Pediatrics and Adolescent Medicine, University Medical Center Freiburg, 79106 Freiburg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Fribourg-en-Brisgau</region>
<settlement type="city">Fribourg-en-Brisgau</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Schuller, Ulrich" sort="Schuller, Ulrich" uniqKey="Schuller U" first="Ulrich" last="Schüller">Ulrich Schüller</name>
<affiliation wicri:level="4">
<nlm:aff id="A50"> Department of Neuropathology, Ludwig-Maximilians-University, and German Cancer Consortium (DKTK) partner site Munich, 81377 Munich, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Ludwig-Maximilians-University, and German Cancer Consortium (DKTK) partner site Munich, 81377 Munich</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
</author>
<author>
<name sortKey="Ebinger, Martin" sort="Ebinger, Martin" uniqKey="Ebinger M" first="Martin" last="Ebinger">Martin Ebinger</name>
<affiliation wicri:level="1">
<nlm:aff id="A51"> Department of Hematology and Oncology, Children's University Hospital Tübingen, and German Cancer Consortium (DKTK) partner site Tübingen, 72076 Tübingen, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Hematology and Oncology, Children's University Hospital Tübingen, and German Cancer Consortium (DKTK) partner site Tübingen, 72076 Tübingen</wicri:regionArea>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Schittenhelm, Jens" sort="Schittenhelm, Jens" uniqKey="Schittenhelm J" first="Jens" last="Schittenhelm">Jens Schittenhelm</name>
<affiliation wicri:level="1">
<nlm:aff id="A52"> Department of Neuropathology, Institute of Pathology and Neuropathology, University of Tübingen, and German Cancer Consortium (DKTK) partner site Tübingen, 72076 Tübingen, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Institute of Pathology and Neuropathology, University of Tübingen, and German Cancer Consortium (DKTK) partner site Tübingen, 72076 Tübingen</wicri:regionArea>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Frank, Stephan" sort="Frank, Stephan" uniqKey="Frank S" first="Stephan" last="Frank">Stephan Frank</name>
<affiliation wicri:level="1">
<nlm:aff id="A53"> Department of Neuropathology, Institute of Pathology, Basel University Hospital, 4031 Basel, Switzerland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Suisse</country>
<wicri:regionArea> Department of Neuropathology, Institute of Pathology, Basel University Hospital, 4031 Basel</wicri:regionArea>
<wicri:noRegion>4031 Basel</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Grobholz, Rainer" sort="Grobholz, Rainer" uniqKey="Grobholz R" first="Rainer" last="Grobholz">Rainer Grobholz</name>
<affiliation wicri:level="1">
<nlm:aff id="A54"> Department of Pathology, Medical Center Aarau, 5001 Aarau, Switzerland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Suisse</country>
<wicri:regionArea> Department of Pathology, Medical Center Aarau, 5001 Aarau</wicri:regionArea>
<wicri:noRegion>5001 Aarau</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Vajtai, Istvan" sort="Vajtai, Istvan" uniqKey="Vajtai I" first="Istvan" last="Vajtai">Istvan Vajtai</name>
<affiliation wicri:level="1">
<nlm:aff id="A55"> Department of Pathology, University Hospital Bern, 3010 Bern, Switzerland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Suisse</country>
<wicri:regionArea> Department of Pathology, University Hospital Bern, 3010 Bern</wicri:regionArea>
<placeName>
<settlement type="city">Berne</settlement>
<region type="région" nuts="3">Canton de Berne</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hans, Volkmar" sort="Hans, Volkmar" uniqKey="Hans V" first="Volkmar" last="Hans">Volkmar Hans</name>
<affiliation wicri:level="1">
<nlm:aff id="A56"> Department of Neuropathology, Medical Center Bielefeld, 33617 Bielefeld, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Medical Center Bielefeld, 33617 Bielefeld</wicri:regionArea>
<wicri:noRegion>33617 Bielefeld</wicri:noRegion>
<wicri:noRegion>33617 Bielefeld</wicri:noRegion>
<wicri:noRegion>33617 Bielefeld</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Schneppenheim, Reinhard" sort="Schneppenheim, Reinhard" uniqKey="Schneppenheim R" first="Reinhard" last="Schneppenheim">Reinhard Schneppenheim</name>
<affiliation wicri:level="1">
<nlm:aff id="A42"> Department of Pediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg</wicri:regionArea>
<wicri:noRegion>20246 Hamburg</wicri:noRegion>
<placeName>
<settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Zitterbart, Karel" sort="Zitterbart, Karel" uniqKey="Zitterbart K" first="Karel" last="Zitterbart">Karel Zitterbart</name>
<affiliation wicri:level="1">
<nlm:aff id="A57"> Department of Pediatric Oncology, University Hospital Brno and Masaryk University, Faculty of Medicine, 613 00 Brno, Czech Republic.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République tchèque</country>
<wicri:regionArea> Department of Pediatric Oncology, University Hospital Brno and Masaryk University, Faculty of Medicine, 613 00 Brno</wicri:regionArea>
<wicri:noRegion>613 00 Brno</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Collins, V Peter" sort="Collins, V Peter" uniqKey="Collins V" first="V. Peter" last="Collins">V. Peter Collins</name>
<affiliation wicri:level="4">
<nlm:aff id="A58"> Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea> Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, CB2 0QQ</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName>
<settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Aronica, Eleonora" sort="Aronica, Eleonora" uniqKey="Aronica E" first="Eleonora" last="Aronica">Eleonora Aronica</name>
<affiliation wicri:level="4">
<nlm:aff id="A59"> Department of Neuropathology, AMC, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea> Department of Neuropathology, AMC, University of Amsterdam, Amsterdam, 1105 AZ</wicri:regionArea>
<orgName type="university">Université d'Amsterdam</orgName>
<placeName>
<settlement type="city">Amsterdam</settlement>
<region>Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Varlet, Pascale" sort="Varlet, Pascale" uniqKey="Varlet P" first="Pascale" last="Varlet">Pascale Varlet</name>
<affiliation wicri:level="3">
<nlm:aff id="A60"> Department of Neuropathology, Hôpital Sainte-Anne, 75674, Paris, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea> Department of Neuropathology, Hôpital Sainte-Anne, 75674, Paris</wicri:regionArea>
<placeName>
<settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Puget, Stephanie" sort="Puget, Stephanie" uniqKey="Puget S" first="Stephanie" last="Puget">Stephanie Puget</name>
<affiliation wicri:level="3">
<nlm:aff id="A61"> Pediatric Neurosurgery Department, Necker Enfants Malades Hospital, 75015, Paris, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea> Pediatric Neurosurgery Department, Necker Enfants Malades Hospital, 75015, Paris</wicri:regionArea>
<placeName>
<settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Dufour, Christelle" sort="Dufour, Christelle" uniqKey="Dufour C" first="Christelle" last="Dufour">Christelle Dufour</name>
<affiliation wicri:level="1">
<nlm:aff id="A62"> Brain Tumor Program, Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Institute, University Paris Sud, 94805, Villejuif, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea> Brain Tumor Program, Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Institute, University Paris Sud, 94805, Villejuif</wicri:regionArea>
<wicri:noRegion>94805, Villejuif</wicri:noRegion>
<wicri:noRegion>94805, Villejuif</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Grill, Jacques" sort="Grill, Jacques" uniqKey="Grill J" first="Jacques" last="Grill">Jacques Grill</name>
<affiliation wicri:level="1">
<nlm:aff id="A62"> Brain Tumor Program, Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Institute, University Paris Sud, 94805, Villejuif, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea> Brain Tumor Program, Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Institute, University Paris Sud, 94805, Villejuif</wicri:regionArea>
<wicri:noRegion>94805, Villejuif</wicri:noRegion>
<wicri:noRegion>94805, Villejuif</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Figarella Branger, Dominique" sort="Figarella Branger, Dominique" uniqKey="Figarella Branger D" first="Dominique" last="Figarella-Branger">Dominique Figarella-Branger</name>
<affiliation wicri:level="1">
<nlm:aff id="A63"> Department of Pathology and Neuropathology, la Timone Hospital, AP-HM and UMR911 CR02, Aix-Marseille University, 13385 Marseille, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea> Department of Pathology and Neuropathology, la Timone Hospital, AP-HM and UMR911 CR02, Aix-Marseille University, 13385 Marseille</wicri:regionArea>
<wicri:noRegion>13385 Marseille</wicri:noRegion>
<placeName>
<settlement type="city">Marseille</settlement>
<region type="région" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Wolter, Marietta" sort="Wolter, Marietta" uniqKey="Wolter M" first="Marietta" last="Wolter">Marietta Wolter</name>
<affiliation wicri:level="3">
<nlm:aff id="A64"> Department of Neuropathology, Heinrich-Heine-University, and German Cancer Consortium (DKTK) partner site Essen/Düsseldorf, 40225 Düsseldorf, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Heinrich-Heine-University, and German Cancer Consortium (DKTK) partner site Essen/Düsseldorf, 40225 Düsseldorf</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Schuhmann, Martin U" sort="Schuhmann, Martin U" uniqKey="Schuhmann M" first="Martin U." last="Schuhmann">Martin U. Schuhmann</name>
<affiliation wicri:level="1">
<nlm:aff id="A65"> Department of Neurosurgery, Section of Pediatric Neurosurgery, University Hospital Tübingen, and German Cancer Consortium (DKTK) partner site Tübingen, 72076 Tübingen, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neurosurgery, Section of Pediatric Neurosurgery, University Hospital Tübingen, and German Cancer Consortium (DKTK) partner site Tübingen, 72076 Tübingen</wicri:regionArea>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Shalaby, Tarek" sort="Shalaby, Tarek" uniqKey="Shalaby T" first="Tarek" last="Shalaby">Tarek Shalaby</name>
<affiliation wicri:level="1">
<nlm:aff id="A66"> Neuro-Oncology Program, Division of Oncology, University Children's Hospital Zurich, 8032 Zürich, Switzerland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Suisse</country>
<wicri:regionArea> Neuro-Oncology Program, Division of Oncology, University Children's Hospital Zurich, 8032 Zürich</wicri:regionArea>
<placeName>
<settlement type="city">Zurich</settlement>
<region nuts="3" type="region">Canton de Zurich</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Grotzer, Michael" sort="Grotzer, Michael" uniqKey="Grotzer M" first="Michael" last="Grotzer">Michael Grotzer</name>
<affiliation wicri:level="1">
<nlm:aff id="A66"> Neuro-Oncology Program, Division of Oncology, University Children's Hospital Zurich, 8032 Zürich, Switzerland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Suisse</country>
<wicri:regionArea> Neuro-Oncology Program, Division of Oncology, University Children's Hospital Zurich, 8032 Zürich</wicri:regionArea>
<placeName>
<settlement type="city">Zurich</settlement>
<region nuts="3" type="region">Canton de Zurich</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Van Meter, Timothy" sort="Van Meter, Timothy" uniqKey="Van Meter T" first="Timothy" last="Van Meter">Timothy Van Meter</name>
<affiliation wicri:level="2">
<nlm:aff id="A67"> Virginia Commonwealth University, Richmond, VA 23298, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Virginia Commonwealth University, Richmond, VA 23298</wicri:regionArea>
<placeName>
<region type="state">Virginie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Monoranu, Camelia Maria" sort="Monoranu, Camelia Maria" uniqKey="Monoranu C" first="Camelia-Maria" last="Monoranu">Camelia-Maria Monoranu</name>
<affiliation wicri:level="3">
<nlm:aff id="A68"> Department of Neuropathology, Institute of Pathology, University of Würzburg, and Comprehensive Cancer Center (CCC) Mainfranken, University and University Hospital, 97080 Würzburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Institute of Pathology, University of Würzburg, and Comprehensive Cancer Center (CCC) Mainfranken, University and University Hospital, 97080 Würzburg</wicri:regionArea>
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<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Basse-Franconie</region>
<settlement type="city">Wurtzbourg</settlement>
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</affiliation>
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<author>
<name sortKey="Felsberg, Jorg" sort="Felsberg, Jorg" uniqKey="Felsberg J" first="Jörg" last="Felsberg">Jörg Felsberg</name>
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<nlm:aff id="A64"> Department of Neuropathology, Heinrich-Heine-University, and German Cancer Consortium (DKTK) partner site Essen/Düsseldorf, 40225 Düsseldorf, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Heinrich-Heine-University, and German Cancer Consortium (DKTK) partner site Essen/Düsseldorf, 40225 Düsseldorf</wicri:regionArea>
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<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
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<author>
<name sortKey="Reifenberger, Guido" sort="Reifenberger, Guido" uniqKey="Reifenberger G" first="Guido" last="Reifenberger">Guido Reifenberger</name>
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<nlm:aff id="A64"> Department of Neuropathology, Heinrich-Heine-University, and German Cancer Consortium (DKTK) partner site Essen/Düsseldorf, 40225 Düsseldorf, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Heinrich-Heine-University, and German Cancer Consortium (DKTK) partner site Essen/Düsseldorf, 40225 Düsseldorf</wicri:regionArea>
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<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
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<author>
<name sortKey="Snuderl, Matija" sort="Snuderl, Matija" uniqKey="Snuderl M" first="Matija" last="Snuderl">Matija Snuderl</name>
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<nlm:aff id="A69"> Department of Pathology, Division of Neuropathology, NYU Langone Medical Center, New York, NY 10016, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Pathology, Division of Neuropathology, NYU Langone Medical Center, New York, NY 10016</wicri:regionArea>
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<region type="state">État de New York</region>
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<nlm:aff id="A70"> NYU School of Medicine, New York, NY 10016, USA.</nlm:aff>
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<wicri:regionArea> NYU School of Medicine, New York, NY 10016</wicri:regionArea>
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<nlm:aff id="A71"> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ</wicri:regionArea>
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<settlement type="city">Amsterdam</settlement>
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<author>
<name sortKey="Versteeg, Rogier" sort="Versteeg, Rogier" uniqKey="Versteeg R" first="Rogier" last="Versteeg">Rogier Versteeg</name>
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<nlm:aff id="A71"> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ</wicri:regionArea>
<orgName type="university">Université d'Amsterdam</orgName>
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<settlement type="city">Amsterdam</settlement>
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<name sortKey="Volckmann, Richard" sort="Volckmann, Richard" uniqKey="Volckmann R" first="Richard" last="Volckmann">Richard Volckmann</name>
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<nlm:aff id="A71"> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ</wicri:regionArea>
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<settlement type="city">Amsterdam</settlement>
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<nlm:aff id="A71"> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ</wicri:regionArea>
<orgName type="university">Université d'Amsterdam</orgName>
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<settlement type="city">Amsterdam</settlement>
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<author>
<name sortKey="Wolf, Stephan" sort="Wolf, Stephan" uniqKey="Wolf S" first="Stephan" last="Wolf">Stephan Wolf</name>
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<nlm:aff id="A72"> Genomics and Proteomics Core Facility, High Throughput Sequencing Unit, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Genomics and Proteomics Core Facility, High Throughput Sequencing Unit, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
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<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
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<author>
<name sortKey="Mikkelsen, Tom" sort="Mikkelsen, Tom" uniqKey="Mikkelsen T" first="Tom" last="Mikkelsen">Tom Mikkelsen</name>
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<nlm:aff id="A73"> Departments of Neurology and Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Departments of Neurology and Neurosurgery, Henry Ford Hospital, Detroit, MI 48202</wicri:regionArea>
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<region type="state">Michigan</region>
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<author>
<name sortKey="Gajjar, Amar" sort="Gajjar, Amar" uniqKey="Gajjar A" first="Amar" last="Gajjar">Amar Gajjar</name>
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<nlm:aff id="A74"> Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105</wicri:regionArea>
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<region type="state">Tennessee</region>
</placeName>
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<author>
<name sortKey="Aldape, Kenneth" sort="Aldape, Kenneth" uniqKey="Aldape K" first="Kenneth" last="Aldape">Kenneth Aldape</name>
<affiliation wicri:level="2">
<nlm:aff id="A75"> Department of Neuro-Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neuro-Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030</wicri:regionArea>
<placeName>
<region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Moore, Andrew S" sort="Moore, Andrew S" uniqKey="Moore A" first="Andrew S." last="Moore">Andrew S. Moore</name>
<affiliation wicri:level="1">
<nlm:aff id="A76"> The University of Queensland Diamantina Institute, Translational Research Institute; UQ Child Health Research Centre, The University of Queensland; Queensland Children's Medical Research Institute, Children's Health Queensland Hospital and Health Service; Brisbane, Australia.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Australie</country>
<wicri:regionArea> The University of Queensland Diamantina Institute, Translational Research Institute; UQ Child Health Research Centre, The University of Queensland; Queensland Children's Medical Research Institute, Children's Health Queensland Hospital and Health Service; Brisbane</wicri:regionArea>
<wicri:noRegion>Children's Health Queensland Hospital and Health Service; Brisbane</wicri:noRegion>
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<author>
<name sortKey="Taylor, Michael D" sort="Taylor, Michael D" uniqKey="Taylor M" first="Michael D." last="Taylor">Michael D. Taylor</name>
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<nlm:aff id="A14"> Program in Developmental and Stem Cell Biology, Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Toronto, ON M4N 1X8, Canada.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Canada</country>
<wicri:regionArea> Program in Developmental and Stem Cell Biology, Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Toronto, ON M4N 1X8</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
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<settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
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<author>
<name sortKey="Jones, Chris" sort="Jones, Chris" uniqKey="Jones C" first="Chris" last="Jones">Chris Jones</name>
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<nlm:aff id="A13"> Division of Molecular Pathology, The Institute of Cancer Research, SW7 3RP, London, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea> Division of Molecular Pathology, The Institute of Cancer Research, SW7 3RP, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
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<name sortKey="Jabado, Nada" sort="Jabado, Nada" uniqKey="Jabado N" first="Nada" last="Jabado">Nada Jabado</name>
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<nlm:aff id="A77"> McGill University and Genome Quebec Innovation Centre, Montreal, QC H3A 1A4, Canada.</nlm:aff>
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<wicri:regionArea> McGill University and Genome Quebec Innovation Centre, Montreal, QC H3A 1A4</wicri:regionArea>
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<author>
<name sortKey="Karajannis, Matthias A" sort="Karajannis, Matthias A" uniqKey="Karajannis M" first="Matthias A." last="Karajannis">Matthias A. Karajannis</name>
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<nlm:aff id="A78"> Departments of Pediatrics and Otolaryngology, Division of Pediatric Hematology/Oncology, NYU Langone Medical Center and Laura and Isaac Perlmutter Cancer Center, NY 10016, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Departments of Pediatrics and Otolaryngology, Division of Pediatric Hematology/Oncology, NYU Langone Medical Center and Laura and Isaac Perlmutter Cancer Center, NY 10016, New York</wicri:regionArea>
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<region type="state">État de New York</region>
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<name sortKey="Eils, Roland" sort="Eils, Roland" uniqKey="Eils R" first="Roland" last="Eils">Roland Eils</name>
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<nlm:aff id="A4"> Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
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<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
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</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A79"> Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant, Heidelberg University, Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant, Heidelberg University, Heidelberg</wicri:regionArea>
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<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
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<affiliation wicri:level="3">
<nlm:aff id="A80"> Heidelberg Center for Personalized Oncology, DKFZ-HIPO, DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Heidelberg Center for Personalized Oncology, DKFZ-HIPO, DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg</wicri:regionArea>
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<region type="land" nuts="1">Bade-Wurtemberg</region>
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<name sortKey="Schlesner, Matthias" sort="Schlesner, Matthias" uniqKey="Schlesner M" first="Matthias" last="Schlesner">Matthias Schlesner</name>
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<nlm:aff id="A4"> Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
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<region type="land" nuts="1">Bade-Wurtemberg</region>
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<name sortKey="Lichter, Peter" sort="Lichter, Peter" uniqKey="Lichter P" first="Peter" last="Lichter">Peter Lichter</name>
<affiliation wicri:level="3">
<nlm:aff id="A5"> Division of Molecular Genetics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Molecular Genetics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
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<region type="land" nuts="1">Bade-Wurtemberg</region>
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<nlm:aff id="A80"> Heidelberg Center for Personalized Oncology, DKFZ-HIPO, DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany.</nlm:aff>
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<wicri:regionArea> Heidelberg Center for Personalized Oncology, DKFZ-HIPO, DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg</wicri:regionArea>
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<region type="land" nuts="1">Bade-Wurtemberg</region>
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<name sortKey="Von Deimling, Andreas" sort="Von Deimling, Andreas" uniqKey="Von Deimling A" first="Andreas" last="Von Deimling">Andreas Von Deimling</name>
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<nlm:aff id="A6"> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
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<name sortKey="Pfister, Stefan M" sort="Pfister, Stefan M" uniqKey="Pfister S" first="Stefan M." last="Pfister">Stefan M. Pfister</name>
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<nlm:aff id="A1"> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
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<region type="land" nuts="1">Bade-Wurtemberg</region>
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<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
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<region type="land" nuts="1">Bade-Wurtemberg</region>
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<name sortKey="Ellison, David W" sort="Ellison, David W" uniqKey="Ellison D" first="David W." last="Ellison">David W. Ellison</name>
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<nlm:aff id="A3"> Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105-3678, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105-3678</wicri:regionArea>
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<region type="state">Tennessee</region>
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<nlm:aff id="A6"> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
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<nlm:aff id="A7"> Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg.</nlm:aff>
<wicri:noCountry code="subfield">69120 Heidelberg.</wicri:noCountry>
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<nlm:aff id="A1"> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
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<region type="land" nuts="1">Bade-Wurtemberg</region>
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<title xml:lang="en" level="a" type="main">New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs</title>
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<name sortKey="Sturm, Dominik" sort="Sturm, Dominik" uniqKey="Sturm D" first="Dominik" last="Sturm">Dominik Sturm</name>
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<nlm:aff id="A1"> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A2"> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Orr, Brent A" sort="Orr, Brent A" uniqKey="Orr B" first="Brent A." last="Orr">Brent A. Orr</name>
<affiliation wicri:level="2">
<nlm:aff id="A3"> Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105-3678, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105-3678</wicri:regionArea>
<placeName>
<region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Toprak, Umut H" sort="Toprak, Umut H" uniqKey="Toprak U" first="Umut H." last="Toprak">Umut H. Toprak</name>
<affiliation wicri:level="3">
<nlm:aff id="A4"> Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hovestadt, Volker" sort="Hovestadt, Volker" uniqKey="Hovestadt V" first="Volker" last="Hovestadt">Volker Hovestadt</name>
<affiliation wicri:level="3">
<nlm:aff id="A5"> Division of Molecular Genetics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Molecular Genetics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Jones, David T W" sort="Jones, David T W" uniqKey="Jones D" first="David T. W." last="Jones">David T. W. Jones</name>
<affiliation wicri:level="3">
<nlm:aff id="A1"> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Capper, David" sort="Capper, David" uniqKey="Capper D" first="David" last="Capper">David Capper</name>
<affiliation wicri:level="3">
<nlm:aff id="A6"> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation>
<nlm:aff id="A7"> Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg.</nlm:aff>
<wicri:noCountry code="subfield">69120 Heidelberg.</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Sill, Martin" sort="Sill, Martin" uniqKey="Sill M" first="Martin" last="Sill">Martin Sill</name>
<affiliation wicri:level="3">
<nlm:aff id="A8"> Division of Biostatistics, German Cancer Research Center (DKFZ) Heidelberg and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Biostatistics, German Cancer Research Center (DKFZ) Heidelberg and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Buchhalter, Ivo" sort="Buchhalter, Ivo" uniqKey="Buchhalter I" first="Ivo" last="Buchhalter">Ivo Buchhalter</name>
<affiliation wicri:level="3">
<nlm:aff id="A4"> Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Northcott, Paul A" sort="Northcott, Paul A" uniqKey="Northcott P" first="Paul A." last="Northcott">Paul A. Northcott</name>
<affiliation wicri:level="3">
<nlm:aff id="A1"> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Leis, Irina" sort="Leis, Irina" uniqKey="Leis I" first="Irina" last="Leis">Irina Leis</name>
<affiliation wicri:level="3">
<nlm:aff id="A6"> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Ryzhova, Marina" sort="Ryzhova, Marina" uniqKey="Ryzhova M" first="Marina" last="Ryzhova">Marina Ryzhova</name>
<affiliation wicri:level="3">
<nlm:aff id="A9"> NN Burdenko Neurosurgical Institute, Moscow, 125047 Russia.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Russie</country>
<wicri:regionArea> NN Burdenko Neurosurgical Institute, Moscow</wicri:regionArea>
<placeName>
<settlement type="city">Moscou</settlement>
<region>District fédéral central</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Koelsche, Christian" sort="Koelsche, Christian" uniqKey="Koelsche C" first="Christian" last="Koelsche">Christian Koelsche</name>
<affiliation wicri:level="3">
<nlm:aff id="A6"> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation>
<nlm:aff id="A7"> Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg.</nlm:aff>
<wicri:noCountry code="subfield">69120 Heidelberg.</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Pfaff, Elke" sort="Pfaff, Elke" uniqKey="Pfaff E" first="Elke" last="Pfaff">Elke Pfaff</name>
<affiliation wicri:level="3">
<nlm:aff id="A1"> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A2"> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Allen, Sariah J" sort="Allen, Sariah J" uniqKey="Allen S" first="Sariah J." last="Allen">Sariah J. Allen</name>
<affiliation wicri:level="2">
<nlm:aff id="A3"> Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105-3678, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105-3678</wicri:regionArea>
<placeName>
<region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Balasubramanian, Gnanaprakash" sort="Balasubramanian, Gnanaprakash" uniqKey="Balasubramanian G" first="Gnanaprakash" last="Balasubramanian">Gnanaprakash Balasubramanian</name>
<affiliation wicri:level="3">
<nlm:aff id="A10"> Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), National Center for Tumor Diseases (NCT), and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), National Center for Tumor Diseases (NCT), and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Worst, Barbara C" sort="Worst, Barbara C" uniqKey="Worst B" first="Barbara C." last="Worst">Barbara C. Worst</name>
<affiliation wicri:level="3">
<nlm:aff id="A1"> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A2"> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Pajtler, Kristian W" sort="Pajtler, Kristian W" uniqKey="Pajtler K" first="Kristian W." last="Pajtler">Kristian W. Pajtler</name>
<affiliation wicri:level="3">
<nlm:aff id="A1"> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Brabetz, Sebastian" sort="Brabetz, Sebastian" uniqKey="Brabetz S" first="Sebastian" last="Brabetz">Sebastian Brabetz</name>
<affiliation wicri:level="3">
<nlm:aff id="A1"> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Johann, Pascal D" sort="Johann, Pascal D" uniqKey="Johann P" first="Pascal D." last="Johann">Pascal D. Johann</name>
<affiliation wicri:level="3">
<nlm:aff id="A1"> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A2"> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Sahm, Felix" sort="Sahm, Felix" uniqKey="Sahm F" first="Felix" last="Sahm">Felix Sahm</name>
<affiliation wicri:level="3">
<nlm:aff id="A6"> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation>
<nlm:aff id="A7"> Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg.</nlm:aff>
<wicri:noCountry code="subfield">69120 Heidelberg.</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Reimand, Juri" sort="Reimand, Juri" uniqKey="Reimand J" first="Jüri" last="Reimand">Jüri Reimand</name>
<affiliation wicri:level="1">
<nlm:aff id="A11"> Ontario Institute for Cancer Research, M5G 0A3, Toronto, ON M5G 1L7, Canada.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Canada</country>
<wicri:regionArea> Ontario Institute for Cancer Research, M5G 0A3, Toronto, ON M5G 1L7</wicri:regionArea>
<wicri:noRegion>ON M5G 1L7</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A12"> Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Canada</country>
<wicri:regionArea> Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName>
<settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Mackay, Alan" sort="Mackay, Alan" uniqKey="Mackay A" first="Alan" last="Mackay">Alan Mackay</name>
<affiliation wicri:level="3">
<nlm:aff id="A13"> Division of Molecular Pathology, The Institute of Cancer Research, SW7 3RP, London, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea> Division of Molecular Pathology, The Institute of Cancer Research, SW7 3RP, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Carvalho, Diana M" sort="Carvalho, Diana M" uniqKey="Carvalho D" first="Diana M." last="Carvalho">Diana M. Carvalho</name>
<affiliation wicri:level="3">
<nlm:aff id="A13"> Division of Molecular Pathology, The Institute of Cancer Research, SW7 3RP, London, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea> Division of Molecular Pathology, The Institute of Cancer Research, SW7 3RP, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Remke, Marc" sort="Remke, Marc" uniqKey="Remke M" first="Marc" last="Remke">Marc Remke</name>
<affiliation wicri:level="4">
<nlm:aff id="A14"> Program in Developmental and Stem Cell Biology, Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Toronto, ON M4N 1X8, Canada.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Canada</country>
<wicri:regionArea> Program in Developmental and Stem Cell Biology, Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Toronto, ON M4N 1X8</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName>
<settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Phillips, Joanna J" sort="Phillips, Joanna J" uniqKey="Phillips J" first="Joanna J." last="Phillips">Joanna J. Phillips</name>
<affiliation wicri:level="2">
<nlm:aff id="A15"> Brain Tumor Research Center, University of California, San Francisco, CA 94158-9001, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Brain Tumor Research Center, University of California, San Francisco, CA 94158-9001</wicri:regionArea>
<placeName>
<region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A16"> Neuropathology, Department of Pathology, University of California, San Francisco, CA 94143-0102, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Neuropathology, Department of Pathology, University of California, San Francisco, CA 94143-0102</wicri:regionArea>
<placeName>
<region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A17"> Department of Neurological Surgery, University of California, San Francisco, CA 94143-0112, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurological Surgery, University of California, San Francisco, CA 94143-0112</wicri:regionArea>
<placeName>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Perry, Arie" sort="Perry, Arie" uniqKey="Perry A" first="Arie" last="Perry">Arie Perry</name>
<affiliation wicri:level="2">
<nlm:aff id="A15"> Brain Tumor Research Center, University of California, San Francisco, CA 94158-9001, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Brain Tumor Research Center, University of California, San Francisco, CA 94158-9001</wicri:regionArea>
<placeName>
<region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A16"> Neuropathology, Department of Pathology, University of California, San Francisco, CA 94143-0102, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Neuropathology, Department of Pathology, University of California, San Francisco, CA 94143-0102</wicri:regionArea>
<placeName>
<region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A17"> Department of Neurological Surgery, University of California, San Francisco, CA 94143-0112, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neurological Surgery, University of California, San Francisco, CA 94143-0112</wicri:regionArea>
<placeName>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Cowdrey, Cynthia" sort="Cowdrey, Cynthia" uniqKey="Cowdrey C" first="Cynthia" last="Cowdrey">Cynthia Cowdrey</name>
<affiliation wicri:level="2">
<nlm:aff id="A15"> Brain Tumor Research Center, University of California, San Francisco, CA 94158-9001, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Brain Tumor Research Center, University of California, San Francisco, CA 94158-9001</wicri:regionArea>
<placeName>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Drissi, Rachid" sort="Drissi, Rachid" uniqKey="Drissi R" first="Rachid" last="Drissi">Rachid Drissi</name>
<affiliation wicri:level="2">
<nlm:aff id="A18"> Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229</wicri:regionArea>
<placeName>
<region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Fouladi, Maryam" sort="Fouladi, Maryam" uniqKey="Fouladi M" first="Maryam" last="Fouladi">Maryam Fouladi</name>
<affiliation wicri:level="2">
<nlm:aff id="A18"> Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229</wicri:regionArea>
<placeName>
<region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Giangaspero, Felice" sort="Giangaspero, Felice" uniqKey="Giangaspero F" first="Felice" last="Giangaspero">Felice Giangaspero</name>
<affiliation wicri:level="1">
<nlm:aff id="A19"> Department of Radiological, Oncological and Anatomic-Pathological Sciences, Sapienza University of Rome, 00185 Rome, Italy.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Italie</country>
<wicri:regionArea> Department of Radiological, Oncological and Anatomic-Pathological Sciences, Sapienza University of Rome, 00185 Rome</wicri:regionArea>
<placeName>
<settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A20"> IRCCS Neuromed, 86077 Pozzilli, Molise, Italy.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Italie</country>
<wicri:regionArea> IRCCS Neuromed, 86077 Pozzilli, Molise</wicri:regionArea>
<wicri:noRegion>Molise</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Lastowska, Maria" sort="Lastowska, Maria" uniqKey="Lastowska M" first="Maria" last="Łastowska">Maria Łastowska</name>
<affiliation wicri:level="1">
<nlm:aff id="A21"> Department of Pathology, Children's Memorial Health Institute, 04-730 Warsaw, Poland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pologne</country>
<wicri:regionArea> Department of Pathology, Children's Memorial Health Institute, 04-730 Warsaw</wicri:regionArea>
<wicri:noRegion>04-730 Warsaw</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Grajkowska, Wieslawa" sort="Grajkowska, Wieslawa" uniqKey="Grajkowska W" first="Wiesława" last="Grajkowska">Wiesława Grajkowska</name>
<affiliation wicri:level="1">
<nlm:aff id="A21"> Department of Pathology, Children's Memorial Health Institute, 04-730 Warsaw, Poland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pologne</country>
<wicri:regionArea> Department of Pathology, Children's Memorial Health Institute, 04-730 Warsaw</wicri:regionArea>
<wicri:noRegion>04-730 Warsaw</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Scheurlen, Wolfram" sort="Scheurlen, Wolfram" uniqKey="Scheurlen W" first="Wolfram" last="Scheurlen">Wolfram Scheurlen</name>
<affiliation wicri:level="1">
<nlm:aff id="A22"> Cnopf'sche Kinderklinik, Nürnberg Children's Hospital, 90419 Nürnberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Cnopf'sche Kinderklinik, Nürnberg Children's Hospital, 90419 Nürnberg</wicri:regionArea>
<wicri:noRegion>90419 Nürnberg</wicri:noRegion>
<wicri:noRegion>90419 Nürnberg</wicri:noRegion>
<wicri:noRegion>90419 Nürnberg</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Pietsch, Torsten" sort="Pietsch, Torsten" uniqKey="Pietsch T" first="Torsten" last="Pietsch">Torsten Pietsch</name>
<affiliation wicri:level="1">
<nlm:aff id="A23"> Department of Neuropathology, University of Bonn Medical School, 53105 Bonn, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, University of Bonn Medical School, 53105 Bonn</wicri:regionArea>
<wicri:noRegion>53105 Bonn</wicri:noRegion>
<placeName>
<settlement type="city">Bonn</settlement>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hagel, Christian" sort="Hagel, Christian" uniqKey="Hagel C" first="Christian" last="Hagel">Christian Hagel</name>
<affiliation wicri:level="1">
<nlm:aff id="A24"> Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg</wicri:regionArea>
<wicri:noRegion>20246 Hamburg</wicri:noRegion>
<placeName>
<settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Gojo, Johannes" sort="Gojo, Johannes" uniqKey="Gojo J" first="Johannes" last="Gojo">Johannes Gojo</name>
<affiliation wicri:level="3">
<nlm:aff id="A25"> Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, 1090 Vienna, Austria.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Autriche</country>
<wicri:regionArea> Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, 1090 Vienna</wicri:regionArea>
<placeName>
<region type="land" nuts="2">Vienne (Autriche)</region>
<settlement type="city">Vienne (Autriche)</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A26"> Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Autriche</country>
<wicri:regionArea> Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna</wicri:regionArea>
<placeName>
<region type="land" nuts="2">Vienne (Autriche)</region>
<settlement type="city">Vienne (Autriche)</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Lotsch, Daniela" sort="Lotsch, Daniela" uniqKey="Lotsch D" first="Daniela" last="Lötsch">Daniela Lötsch</name>
<affiliation wicri:level="3">
<nlm:aff id="A26"> Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Autriche</country>
<wicri:regionArea> Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna</wicri:regionArea>
<placeName>
<region type="land" nuts="2">Vienne (Autriche)</region>
<settlement type="city">Vienne (Autriche)</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Berger, Walter" sort="Berger, Walter" uniqKey="Berger W" first="Walter" last="Berger">Walter Berger</name>
<affiliation wicri:level="3">
<nlm:aff id="A26"> Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Autriche</country>
<wicri:regionArea> Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna</wicri:regionArea>
<placeName>
<region type="land" nuts="2">Vienne (Autriche)</region>
<settlement type="city">Vienne (Autriche)</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Slavc, Irene" sort="Slavc, Irene" uniqKey="Slavc I" first="Irene" last="Slavc">Irene Slavc</name>
<affiliation wicri:level="3">
<nlm:aff id="A25"> Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, 1090 Vienna, Austria.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Autriche</country>
<wicri:regionArea> Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, 1090 Vienna</wicri:regionArea>
<placeName>
<region type="land" nuts="2">Vienne (Autriche)</region>
<settlement type="city">Vienne (Autriche)</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Haberler, Christine" sort="Haberler, Christine" uniqKey="Haberler C" first="Christine" last="Haberler">Christine Haberler</name>
<affiliation wicri:level="3">
<nlm:aff id="A27"> Institute of Neurology, Medical University of Vienna, 1097 Vienna, Austria.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Autriche</country>
<wicri:regionArea> Institute of Neurology, Medical University of Vienna, 1097 Vienna</wicri:regionArea>
<placeName>
<region type="land" nuts="2">Vienne (Autriche)</region>
<settlement type="city">Vienne (Autriche)</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Jouvet, Anne" sort="Jouvet, Anne" uniqKey="Jouvet A" first="Anne" last="Jouvet">Anne Jouvet</name>
<affiliation wicri:level="1">
<nlm:aff id="A28"> Neuro-Oncology and Neuro-Inflammation Team, Inserm U1028, CNRS UMR 5292, University Lyon-1, Neuroscience Center, 69000 Lyon, France, and Centre de Pathologie et de Neuropathologie Est, Hospices Civils de Lyon, 69003 Lyon, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea> Neuro-Oncology and Neuro-Inflammation Team, Inserm U1028, CNRS UMR 5292, University Lyon-1, Neuroscience Center, 69000 Lyon, France, and Centre de Pathologie et de Neuropathologie Est, Hospices Civils de Lyon, 69003 Lyon</wicri:regionArea>
<wicri:noRegion>69003 Lyon</wicri:noRegion>
<placeName>
<settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Holm, Stefan" sort="Holm, Stefan" uniqKey="Holm S" first="Stefan" last="Holm">Stefan Holm</name>
<affiliation wicri:level="1">
<nlm:aff id="A29"> Department of Women's and Children's Health (KBH), Karolinska Institutet, SE-171 77 Stockholm, Sweden.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Suède</country>
<wicri:regionArea> Department of Women's and Children's Health (KBH), Karolinska Institutet, SE-171 77 Stockholm</wicri:regionArea>
<wicri:noRegion>SE-171 77 Stockholm</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hofer, Silvia" sort="Hofer, Silvia" uniqKey="Hofer S" first="Silvia" last="Hofer">Silvia Hofer</name>
<affiliation wicri:level="1">
<nlm:aff id="A30"> Department of Oncology, Luzerner Kantonsspital, 6000 Luzern 16, Luzern, Switzerland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Suisse</country>
<wicri:regionArea> Department of Oncology, Luzerner Kantonsspital, 6000 Luzern 16, Luzern</wicri:regionArea>
<wicri:noRegion>Luzern</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Prinz, Marco" sort="Prinz, Marco" uniqKey="Prinz M" first="Marco" last="Prinz">Marco Prinz</name>
<affiliation wicri:level="3">
<nlm:aff id="A31"> Institute of Neuropathology, University of Freiburg, Germany & BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79106 Freiburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Institute of Neuropathology, University of Freiburg, Germany & BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79106 Freiburg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Fribourg-en-Brisgau</region>
<settlement type="city">Fribourg-en-Brisgau</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Keohane, Catherine" sort="Keohane, Catherine" uniqKey="Keohane C" first="Catherine" last="Keohane">Catherine Keohane</name>
<affiliation wicri:level="1">
<nlm:aff id="A32"> Department of Pathology, University College Cork and Cork University Hospital Wilton, Cork, Ireland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Irlande (pays)</country>
<wicri:regionArea> Department of Pathology, University College Cork and Cork University Hospital Wilton, Cork</wicri:regionArea>
<wicri:noRegion>Cork</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Fried, Iris" sort="Fried, Iris" uniqKey="Fried I" first="Iris" last="Fried">Iris Fried</name>
<affiliation wicri:level="1">
<nlm:aff id="A33"> Department of Pediatric Hematology and Oncology, Hadassah Medical Center, Jerusalem, Israel.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Israël</country>
<wicri:regionArea> Department of Pediatric Hematology and Oncology, Hadassah Medical Center, Jerusalem</wicri:regionArea>
<wicri:noRegion>Jerusalem</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Mawrin, Christian" sort="Mawrin, Christian" uniqKey="Mawrin C" first="Christian" last="Mawrin">Christian Mawrin</name>
<affiliation wicri:level="3">
<nlm:aff id="A34"> Institute of Neuropathology, University Hospital, Otto-von-Guericke University, 39120 Magdeburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Institute of Neuropathology, University Hospital, Otto-von-Guericke University, 39120 Magdeburg</wicri:regionArea>
<placeName>
<region type="land" nuts="2">Saxe-Anhalt</region>
<settlement type="city">Magdebourg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Scheie, David" sort="Scheie, David" uniqKey="Scheie D" first="David" last="Scheie">David Scheie</name>
<affiliation wicri:level="1">
<nlm:aff id="A35"> Department of Pathology, Copenhagen University Hospital, 2100 København Ø, Denmark.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Danemark</country>
<wicri:regionArea> Department of Pathology, Copenhagen University Hospital, 2100 København Ø</wicri:regionArea>
<wicri:noRegion>2100 København Ø</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Mobley, Bret C" sort="Mobley, Bret C" uniqKey="Mobley B" first="Bret C." last="Mobley">Bret C. Mobley</name>
<affiliation wicri:level="2">
<nlm:aff id="A36"> Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232</wicri:regionArea>
<placeName>
<region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Schniederjan, Matthew J" sort="Schniederjan, Matthew J" uniqKey="Schniederjan M" first="Matthew J." last="Schniederjan">Matthew J. Schniederjan</name>
<affiliation wicri:level="2">
<nlm:aff id="A37"> Department of Pathology and Laboratory Administration, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Pathology and Laboratory Administration, Children's Healthcare of Atlanta, Atlanta, GA 30322</wicri:regionArea>
<placeName>
<region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Santi, Mariarita" sort="Santi, Mariarita" uniqKey="Santi M" first="Mariarita" last="Santi">Mariarita Santi</name>
<affiliation wicri:level="2">
<nlm:aff id="A38"> Department of Pathology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Pathology, Children's Hospital of Philadelphia, Philadelphia, PA 19104</wicri:regionArea>
<placeName>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Buccoliero, Anna M" sort="Buccoliero, Anna M" uniqKey="Buccoliero A" first="Anna M." last="Buccoliero">Anna M. Buccoliero</name>
<affiliation wicri:level="1">
<nlm:aff id="A39"> Pathology Unit, Anna Meyer Children's University Hospital, 50141 Florence, Italy.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Italie</country>
<wicri:regionArea> Pathology Unit, Anna Meyer Children's University Hospital, 50141 Florence</wicri:regionArea>
<wicri:noRegion>50141 Florence</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Dahiya, Sonika" sort="Dahiya, Sonika" uniqKey="Dahiya S" first="Sonika" last="Dahiya">Sonika Dahiya</name>
<affiliation wicri:level="2">
<nlm:aff id="A40"> Department of Pathology and Immunology, Washington University, St. Louis, MO 63110, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Pathology and Immunology, Washington University, St. Louis, MO 63110</wicri:regionArea>
<placeName>
<region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kramm, Christof M" sort="Kramm, Christof M" uniqKey="Kramm C" first="Christof M." last="Kramm">Christof M. Kramm</name>
<affiliation wicri:level="3">
<nlm:aff id="A41"> Division of Pediatric Hematology and Oncology, Department of Child and Adolescent Health, University Medical Center Göttingen, 37075 Göttingen, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Hematology and Oncology, Department of Child and Adolescent Health, University Medical Center Göttingen, 37075 Göttingen</wicri:regionArea>
<placeName>
<region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Göttingen</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Von Bueren, Andre O" sort="Von Bueren, Andre O" uniqKey="Von Bueren A" first="André O." last="Von Bueren">André O. Von Bueren</name>
<affiliation wicri:level="3">
<nlm:aff id="A41"> Division of Pediatric Hematology and Oncology, Department of Child and Adolescent Health, University Medical Center Göttingen, 37075 Göttingen, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Hematology and Oncology, Department of Child and Adolescent Health, University Medical Center Göttingen, 37075 Göttingen</wicri:regionArea>
<placeName>
<region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Göttingen</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Von Hoff, Katja" sort="Von Hoff, Katja" uniqKey="Von Hoff K" first="Katja" last="Von Hoff">Katja Von Hoff</name>
<affiliation wicri:level="1">
<nlm:aff id="A42"> Department of Pediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg</wicri:regionArea>
<wicri:noRegion>20246 Hamburg</wicri:noRegion>
<placeName>
<settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Rutkowski, Stefan" sort="Rutkowski, Stefan" uniqKey="Rutkowski S" first="Stefan" last="Rutkowski">Stefan Rutkowski</name>
<affiliation wicri:level="1">
<nlm:aff id="A42"> Department of Pediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg</wicri:regionArea>
<wicri:noRegion>20246 Hamburg</wicri:noRegion>
<placeName>
<settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Herold Mende, Christel" sort="Herold Mende, Christel" uniqKey="Herold Mende C" first="Christel" last="Herold-Mende">Christel Herold-Mende</name>
<affiliation wicri:level="3">
<nlm:aff id="A43"> Department of Neurosurgery, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neurosurgery, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Fruhwald, Michael C" sort="Fruhwald, Michael C" uniqKey="Fruhwald M" first="Michael C." last="Frühwald">Michael C. Frühwald</name>
<affiliation wicri:level="3">
<nlm:aff id="A44"> Pediatric Hospital, Klinikum Augsburg, 86156 Augsburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Pediatric Hospital, Klinikum Augsburg, 86156 Augsburg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Souabe</region>
<settlement type="city">Augsbourg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Milde, Till" sort="Milde, Till" uniqKey="Milde T" first="Till" last="Milde">Till Milde</name>
<affiliation wicri:level="3">
<nlm:aff id="A2"> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A45"> Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hasselblatt, Martin" sort="Hasselblatt, Martin" uniqKey="Hasselblatt M" first="Martin" last="Hasselblatt">Martin Hasselblatt</name>
<affiliation wicri:level="3">
<nlm:aff id="A46"> Institute of Neuropathology, University Hospital Münster, 48149 Münster, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Institute of Neuropathology, University Hospital Münster, 48149 Münster</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Münster</region>
<settlement type="city">Münster</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Wesseling, Pieter" sort="Wesseling, Pieter" uniqKey="Wesseling P" first="Pieter" last="Wesseling">Pieter Wesseling</name>
<affiliation wicri:level="1">
<nlm:aff id="A47"> Department of Pathology, VU University Medical Center Amsterdam, 1008 MB Amsterdam, The Netherlands.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea> Department of Pathology, VU University Medical Center Amsterdam, 1008 MB Amsterdam</wicri:regionArea>
<wicri:noRegion>1008 MB Amsterdam</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A48"> Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, 6525 GA, The Netherlands.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea> Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, 6525 GA</wicri:regionArea>
<wicri:noRegion>6525 GA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Ro Ler, Jochen" sort="Ro Ler, Jochen" uniqKey="Ro Ler J" first="Jochen" last="Rö Ler">Jochen Rö Ler</name>
<affiliation wicri:level="3">
<nlm:aff id="A49"> Department of Pediatric Hematology/Oncology, Center of Pediatrics and Adolescent Medicine, University Medical Center Freiburg, 79106 Freiburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Hematology/Oncology, Center of Pediatrics and Adolescent Medicine, University Medical Center Freiburg, 79106 Freiburg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Fribourg-en-Brisgau</region>
<settlement type="city">Fribourg-en-Brisgau</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Schuller, Ulrich" sort="Schuller, Ulrich" uniqKey="Schuller U" first="Ulrich" last="Schüller">Ulrich Schüller</name>
<affiliation wicri:level="4">
<nlm:aff id="A50"> Department of Neuropathology, Ludwig-Maximilians-University, and German Cancer Consortium (DKTK) partner site Munich, 81377 Munich, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Ludwig-Maximilians-University, and German Cancer Consortium (DKTK) partner site Munich, 81377 Munich</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
</author>
<author>
<name sortKey="Ebinger, Martin" sort="Ebinger, Martin" uniqKey="Ebinger M" first="Martin" last="Ebinger">Martin Ebinger</name>
<affiliation wicri:level="1">
<nlm:aff id="A51"> Department of Hematology and Oncology, Children's University Hospital Tübingen, and German Cancer Consortium (DKTK) partner site Tübingen, 72076 Tübingen, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Hematology and Oncology, Children's University Hospital Tübingen, and German Cancer Consortium (DKTK) partner site Tübingen, 72076 Tübingen</wicri:regionArea>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Schittenhelm, Jens" sort="Schittenhelm, Jens" uniqKey="Schittenhelm J" first="Jens" last="Schittenhelm">Jens Schittenhelm</name>
<affiliation wicri:level="1">
<nlm:aff id="A52"> Department of Neuropathology, Institute of Pathology and Neuropathology, University of Tübingen, and German Cancer Consortium (DKTK) partner site Tübingen, 72076 Tübingen, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Institute of Pathology and Neuropathology, University of Tübingen, and German Cancer Consortium (DKTK) partner site Tübingen, 72076 Tübingen</wicri:regionArea>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Frank, Stephan" sort="Frank, Stephan" uniqKey="Frank S" first="Stephan" last="Frank">Stephan Frank</name>
<affiliation wicri:level="1">
<nlm:aff id="A53"> Department of Neuropathology, Institute of Pathology, Basel University Hospital, 4031 Basel, Switzerland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Suisse</country>
<wicri:regionArea> Department of Neuropathology, Institute of Pathology, Basel University Hospital, 4031 Basel</wicri:regionArea>
<wicri:noRegion>4031 Basel</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Grobholz, Rainer" sort="Grobholz, Rainer" uniqKey="Grobholz R" first="Rainer" last="Grobholz">Rainer Grobholz</name>
<affiliation wicri:level="1">
<nlm:aff id="A54"> Department of Pathology, Medical Center Aarau, 5001 Aarau, Switzerland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Suisse</country>
<wicri:regionArea> Department of Pathology, Medical Center Aarau, 5001 Aarau</wicri:regionArea>
<wicri:noRegion>5001 Aarau</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Vajtai, Istvan" sort="Vajtai, Istvan" uniqKey="Vajtai I" first="Istvan" last="Vajtai">Istvan Vajtai</name>
<affiliation wicri:level="1">
<nlm:aff id="A55"> Department of Pathology, University Hospital Bern, 3010 Bern, Switzerland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Suisse</country>
<wicri:regionArea> Department of Pathology, University Hospital Bern, 3010 Bern</wicri:regionArea>
<placeName>
<settlement type="city">Berne</settlement>
<region type="région" nuts="3">Canton de Berne</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hans, Volkmar" sort="Hans, Volkmar" uniqKey="Hans V" first="Volkmar" last="Hans">Volkmar Hans</name>
<affiliation wicri:level="1">
<nlm:aff id="A56"> Department of Neuropathology, Medical Center Bielefeld, 33617 Bielefeld, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Medical Center Bielefeld, 33617 Bielefeld</wicri:regionArea>
<wicri:noRegion>33617 Bielefeld</wicri:noRegion>
<wicri:noRegion>33617 Bielefeld</wicri:noRegion>
<wicri:noRegion>33617 Bielefeld</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Schneppenheim, Reinhard" sort="Schneppenheim, Reinhard" uniqKey="Schneppenheim R" first="Reinhard" last="Schneppenheim">Reinhard Schneppenheim</name>
<affiliation wicri:level="1">
<nlm:aff id="A42"> Department of Pediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg</wicri:regionArea>
<wicri:noRegion>20246 Hamburg</wicri:noRegion>
<placeName>
<settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Zitterbart, Karel" sort="Zitterbart, Karel" uniqKey="Zitterbart K" first="Karel" last="Zitterbart">Karel Zitterbart</name>
<affiliation wicri:level="1">
<nlm:aff id="A57"> Department of Pediatric Oncology, University Hospital Brno and Masaryk University, Faculty of Medicine, 613 00 Brno, Czech Republic.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République tchèque</country>
<wicri:regionArea> Department of Pediatric Oncology, University Hospital Brno and Masaryk University, Faculty of Medicine, 613 00 Brno</wicri:regionArea>
<wicri:noRegion>613 00 Brno</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Collins, V Peter" sort="Collins, V Peter" uniqKey="Collins V" first="V. Peter" last="Collins">V. Peter Collins</name>
<affiliation wicri:level="4">
<nlm:aff id="A58"> Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea> Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, CB2 0QQ</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName>
<settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Aronica, Eleonora" sort="Aronica, Eleonora" uniqKey="Aronica E" first="Eleonora" last="Aronica">Eleonora Aronica</name>
<affiliation wicri:level="4">
<nlm:aff id="A59"> Department of Neuropathology, AMC, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea> Department of Neuropathology, AMC, University of Amsterdam, Amsterdam, 1105 AZ</wicri:regionArea>
<orgName type="university">Université d'Amsterdam</orgName>
<placeName>
<settlement type="city">Amsterdam</settlement>
<region>Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Varlet, Pascale" sort="Varlet, Pascale" uniqKey="Varlet P" first="Pascale" last="Varlet">Pascale Varlet</name>
<affiliation wicri:level="3">
<nlm:aff id="A60"> Department of Neuropathology, Hôpital Sainte-Anne, 75674, Paris, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea> Department of Neuropathology, Hôpital Sainte-Anne, 75674, Paris</wicri:regionArea>
<placeName>
<settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Puget, Stephanie" sort="Puget, Stephanie" uniqKey="Puget S" first="Stephanie" last="Puget">Stephanie Puget</name>
<affiliation wicri:level="3">
<nlm:aff id="A61"> Pediatric Neurosurgery Department, Necker Enfants Malades Hospital, 75015, Paris, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea> Pediatric Neurosurgery Department, Necker Enfants Malades Hospital, 75015, Paris</wicri:regionArea>
<placeName>
<settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Dufour, Christelle" sort="Dufour, Christelle" uniqKey="Dufour C" first="Christelle" last="Dufour">Christelle Dufour</name>
<affiliation wicri:level="1">
<nlm:aff id="A62"> Brain Tumor Program, Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Institute, University Paris Sud, 94805, Villejuif, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea> Brain Tumor Program, Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Institute, University Paris Sud, 94805, Villejuif</wicri:regionArea>
<wicri:noRegion>94805, Villejuif</wicri:noRegion>
<wicri:noRegion>94805, Villejuif</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Grill, Jacques" sort="Grill, Jacques" uniqKey="Grill J" first="Jacques" last="Grill">Jacques Grill</name>
<affiliation wicri:level="1">
<nlm:aff id="A62"> Brain Tumor Program, Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Institute, University Paris Sud, 94805, Villejuif, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea> Brain Tumor Program, Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Institute, University Paris Sud, 94805, Villejuif</wicri:regionArea>
<wicri:noRegion>94805, Villejuif</wicri:noRegion>
<wicri:noRegion>94805, Villejuif</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Figarella Branger, Dominique" sort="Figarella Branger, Dominique" uniqKey="Figarella Branger D" first="Dominique" last="Figarella-Branger">Dominique Figarella-Branger</name>
<affiliation wicri:level="1">
<nlm:aff id="A63"> Department of Pathology and Neuropathology, la Timone Hospital, AP-HM and UMR911 CR02, Aix-Marseille University, 13385 Marseille, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea> Department of Pathology and Neuropathology, la Timone Hospital, AP-HM and UMR911 CR02, Aix-Marseille University, 13385 Marseille</wicri:regionArea>
<wicri:noRegion>13385 Marseille</wicri:noRegion>
<placeName>
<settlement type="city">Marseille</settlement>
<region type="région" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Wolter, Marietta" sort="Wolter, Marietta" uniqKey="Wolter M" first="Marietta" last="Wolter">Marietta Wolter</name>
<affiliation wicri:level="3">
<nlm:aff id="A64"> Department of Neuropathology, Heinrich-Heine-University, and German Cancer Consortium (DKTK) partner site Essen/Düsseldorf, 40225 Düsseldorf, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Heinrich-Heine-University, and German Cancer Consortium (DKTK) partner site Essen/Düsseldorf, 40225 Düsseldorf</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Schuhmann, Martin U" sort="Schuhmann, Martin U" uniqKey="Schuhmann M" first="Martin U." last="Schuhmann">Martin U. Schuhmann</name>
<affiliation wicri:level="1">
<nlm:aff id="A65"> Department of Neurosurgery, Section of Pediatric Neurosurgery, University Hospital Tübingen, and German Cancer Consortium (DKTK) partner site Tübingen, 72076 Tübingen, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neurosurgery, Section of Pediatric Neurosurgery, University Hospital Tübingen, and German Cancer Consortium (DKTK) partner site Tübingen, 72076 Tübingen</wicri:regionArea>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
<wicri:noRegion>72076 Tübingen</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Shalaby, Tarek" sort="Shalaby, Tarek" uniqKey="Shalaby T" first="Tarek" last="Shalaby">Tarek Shalaby</name>
<affiliation wicri:level="1">
<nlm:aff id="A66"> Neuro-Oncology Program, Division of Oncology, University Children's Hospital Zurich, 8032 Zürich, Switzerland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Suisse</country>
<wicri:regionArea> Neuro-Oncology Program, Division of Oncology, University Children's Hospital Zurich, 8032 Zürich</wicri:regionArea>
<placeName>
<settlement type="city">Zurich</settlement>
<region nuts="3" type="region">Canton de Zurich</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Grotzer, Michael" sort="Grotzer, Michael" uniqKey="Grotzer M" first="Michael" last="Grotzer">Michael Grotzer</name>
<affiliation wicri:level="1">
<nlm:aff id="A66"> Neuro-Oncology Program, Division of Oncology, University Children's Hospital Zurich, 8032 Zürich, Switzerland.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Suisse</country>
<wicri:regionArea> Neuro-Oncology Program, Division of Oncology, University Children's Hospital Zurich, 8032 Zürich</wicri:regionArea>
<placeName>
<settlement type="city">Zurich</settlement>
<region nuts="3" type="region">Canton de Zurich</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Van Meter, Timothy" sort="Van Meter, Timothy" uniqKey="Van Meter T" first="Timothy" last="Van Meter">Timothy Van Meter</name>
<affiliation wicri:level="2">
<nlm:aff id="A67"> Virginia Commonwealth University, Richmond, VA 23298, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Virginia Commonwealth University, Richmond, VA 23298</wicri:regionArea>
<placeName>
<region type="state">Virginie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Monoranu, Camelia Maria" sort="Monoranu, Camelia Maria" uniqKey="Monoranu C" first="Camelia-Maria" last="Monoranu">Camelia-Maria Monoranu</name>
<affiliation wicri:level="3">
<nlm:aff id="A68"> Department of Neuropathology, Institute of Pathology, University of Würzburg, and Comprehensive Cancer Center (CCC) Mainfranken, University and University Hospital, 97080 Würzburg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Institute of Pathology, University of Würzburg, and Comprehensive Cancer Center (CCC) Mainfranken, University and University Hospital, 97080 Würzburg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Basse-Franconie</region>
<settlement type="city">Wurtzbourg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Felsberg, Jorg" sort="Felsberg, Jorg" uniqKey="Felsberg J" first="Jörg" last="Felsberg">Jörg Felsberg</name>
<affiliation wicri:level="3">
<nlm:aff id="A64"> Department of Neuropathology, Heinrich-Heine-University, and German Cancer Consortium (DKTK) partner site Essen/Düsseldorf, 40225 Düsseldorf, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Heinrich-Heine-University, and German Cancer Consortium (DKTK) partner site Essen/Düsseldorf, 40225 Düsseldorf</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Reifenberger, Guido" sort="Reifenberger, Guido" uniqKey="Reifenberger G" first="Guido" last="Reifenberger">Guido Reifenberger</name>
<affiliation wicri:level="3">
<nlm:aff id="A64"> Department of Neuropathology, Heinrich-Heine-University, and German Cancer Consortium (DKTK) partner site Essen/Düsseldorf, 40225 Düsseldorf, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Heinrich-Heine-University, and German Cancer Consortium (DKTK) partner site Essen/Düsseldorf, 40225 Düsseldorf</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Snuderl, Matija" sort="Snuderl, Matija" uniqKey="Snuderl M" first="Matija" last="Snuderl">Matija Snuderl</name>
<affiliation wicri:level="2">
<nlm:aff id="A69"> Department of Pathology, Division of Neuropathology, NYU Langone Medical Center, New York, NY 10016, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Pathology, Division of Neuropathology, NYU Langone Medical Center, New York, NY 10016</wicri:regionArea>
<placeName>
<region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Forrester, Lynn Ann" sort="Forrester, Lynn Ann" uniqKey="Forrester L" first="Lynn Ann" last="Forrester">Lynn Ann Forrester</name>
<affiliation wicri:level="2">
<nlm:aff id="A70"> NYU School of Medicine, New York, NY 10016, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> NYU School of Medicine, New York, NY 10016</wicri:regionArea>
<placeName>
<region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Koster, Jan" sort="Koster, Jan" uniqKey="Koster J" first="Jan" last="Koster">Jan Koster</name>
<affiliation wicri:level="4">
<nlm:aff id="A71"> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ</wicri:regionArea>
<orgName type="university">Université d'Amsterdam</orgName>
<placeName>
<settlement type="city">Amsterdam</settlement>
<region>Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Versteeg, Rogier" sort="Versteeg, Rogier" uniqKey="Versteeg R" first="Rogier" last="Versteeg">Rogier Versteeg</name>
<affiliation wicri:level="4">
<nlm:aff id="A71"> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ</wicri:regionArea>
<orgName type="university">Université d'Amsterdam</orgName>
<placeName>
<settlement type="city">Amsterdam</settlement>
<region>Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Volckmann, Richard" sort="Volckmann, Richard" uniqKey="Volckmann R" first="Richard" last="Volckmann">Richard Volckmann</name>
<affiliation wicri:level="4">
<nlm:aff id="A71"> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ</wicri:regionArea>
<orgName type="university">Université d'Amsterdam</orgName>
<placeName>
<settlement type="city">Amsterdam</settlement>
<region>Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Van Sluis, Peter" sort="Van Sluis, Peter" uniqKey="Van Sluis P" first="Peter" last="Van Sluis">Peter Van Sluis</name>
<affiliation wicri:level="4">
<nlm:aff id="A71"> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea> Department of Oncogenomics, AMC, University of Amsterdam, Amsterdam, 1105 AZ</wicri:regionArea>
<orgName type="university">Université d'Amsterdam</orgName>
<placeName>
<settlement type="city">Amsterdam</settlement>
<region>Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Wolf, Stephan" sort="Wolf, Stephan" uniqKey="Wolf S" first="Stephan" last="Wolf">Stephan Wolf</name>
<affiliation wicri:level="3">
<nlm:aff id="A72"> Genomics and Proteomics Core Facility, High Throughput Sequencing Unit, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Genomics and Proteomics Core Facility, High Throughput Sequencing Unit, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Mikkelsen, Tom" sort="Mikkelsen, Tom" uniqKey="Mikkelsen T" first="Tom" last="Mikkelsen">Tom Mikkelsen</name>
<affiliation wicri:level="2">
<nlm:aff id="A73"> Departments of Neurology and Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Departments of Neurology and Neurosurgery, Henry Ford Hospital, Detroit, MI 48202</wicri:regionArea>
<placeName>
<region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Gajjar, Amar" sort="Gajjar, Amar" uniqKey="Gajjar A" first="Amar" last="Gajjar">Amar Gajjar</name>
<affiliation wicri:level="2">
<nlm:aff id="A74"> Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105</wicri:regionArea>
<placeName>
<region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Aldape, Kenneth" sort="Aldape, Kenneth" uniqKey="Aldape K" first="Kenneth" last="Aldape">Kenneth Aldape</name>
<affiliation wicri:level="2">
<nlm:aff id="A75"> Department of Neuro-Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Neuro-Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030</wicri:regionArea>
<placeName>
<region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Moore, Andrew S" sort="Moore, Andrew S" uniqKey="Moore A" first="Andrew S." last="Moore">Andrew S. Moore</name>
<affiliation wicri:level="1">
<nlm:aff id="A76"> The University of Queensland Diamantina Institute, Translational Research Institute; UQ Child Health Research Centre, The University of Queensland; Queensland Children's Medical Research Institute, Children's Health Queensland Hospital and Health Service; Brisbane, Australia.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Australie</country>
<wicri:regionArea> The University of Queensland Diamantina Institute, Translational Research Institute; UQ Child Health Research Centre, The University of Queensland; Queensland Children's Medical Research Institute, Children's Health Queensland Hospital and Health Service; Brisbane</wicri:regionArea>
<wicri:noRegion>Children's Health Queensland Hospital and Health Service; Brisbane</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Taylor, Michael D" sort="Taylor, Michael D" uniqKey="Taylor M" first="Michael D." last="Taylor">Michael D. Taylor</name>
<affiliation wicri:level="4">
<nlm:aff id="A14"> Program in Developmental and Stem Cell Biology, Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Toronto, ON M4N 1X8, Canada.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Canada</country>
<wicri:regionArea> Program in Developmental and Stem Cell Biology, Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Toronto, ON M4N 1X8</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName>
<settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Jones, Chris" sort="Jones, Chris" uniqKey="Jones C" first="Chris" last="Jones">Chris Jones</name>
<affiliation wicri:level="3">
<nlm:aff id="A13"> Division of Molecular Pathology, The Institute of Cancer Research, SW7 3RP, London, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea> Division of Molecular Pathology, The Institute of Cancer Research, SW7 3RP, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Jabado, Nada" sort="Jabado, Nada" uniqKey="Jabado N" first="Nada" last="Jabado">Nada Jabado</name>
<affiliation wicri:level="1">
<nlm:aff id="A77"> McGill University and Genome Quebec Innovation Centre, Montreal, QC H3A 1A4, Canada.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Canada</country>
<wicri:regionArea> McGill University and Genome Quebec Innovation Centre, Montreal, QC H3A 1A4</wicri:regionArea>
<wicri:noRegion>QC H3A 1A4</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Karajannis, Matthias A" sort="Karajannis, Matthias A" uniqKey="Karajannis M" first="Matthias A." last="Karajannis">Matthias A. Karajannis</name>
<affiliation wicri:level="2">
<nlm:aff id="A78"> Departments of Pediatrics and Otolaryngology, Division of Pediatric Hematology/Oncology, NYU Langone Medical Center and Laura and Isaac Perlmutter Cancer Center, NY 10016, New York, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Departments of Pediatrics and Otolaryngology, Division of Pediatric Hematology/Oncology, NYU Langone Medical Center and Laura and Isaac Perlmutter Cancer Center, NY 10016, New York</wicri:regionArea>
<placeName>
<region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Eils, Roland" sort="Eils, Roland" uniqKey="Eils R" first="Roland" last="Eils">Roland Eils</name>
<affiliation wicri:level="3">
<nlm:aff id="A4"> Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A79"> Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant, Heidelberg University, Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant, Heidelberg University, Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A80"> Heidelberg Center for Personalized Oncology, DKFZ-HIPO, DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Heidelberg Center for Personalized Oncology, DKFZ-HIPO, DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Schlesner, Matthias" sort="Schlesner, Matthias" uniqKey="Schlesner M" first="Matthias" last="Schlesner">Matthias Schlesner</name>
<affiliation wicri:level="3">
<nlm:aff id="A4"> Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Lichter, Peter" sort="Lichter, Peter" uniqKey="Lichter P" first="Peter" last="Lichter">Peter Lichter</name>
<affiliation wicri:level="3">
<nlm:aff id="A5"> Division of Molecular Genetics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Molecular Genetics, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A80"> Heidelberg Center for Personalized Oncology, DKFZ-HIPO, DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Heidelberg Center for Personalized Oncology, DKFZ-HIPO, DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Von Deimling, Andreas" sort="Von Deimling, Andreas" uniqKey="Von Deimling A" first="Andreas" last="Von Deimling">Andreas Von Deimling</name>
<affiliation wicri:level="3">
<nlm:aff id="A6"> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation>
<nlm:aff id="A7"> Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg.</nlm:aff>
<wicri:noCountry code="subfield">69120 Heidelberg.</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Pfister, Stefan M" sort="Pfister, Stefan M" uniqKey="Pfister S" first="Stefan M." last="Pfister">Stefan M. Pfister</name>
<affiliation wicri:level="3">
<nlm:aff id="A1"> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A2"> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Ellison, David W" sort="Ellison, David W" uniqKey="Ellison D" first="David W." last="Ellison">David W. Ellison</name>
<affiliation wicri:level="2">
<nlm:aff id="A3"> Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105-3678, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea> Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105-3678</wicri:regionArea>
<placeName>
<region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Korshunov, Andrey" sort="Korshunov, Andrey" uniqKey="Korshunov A" first="Andrey" last="Korshunov">Andrey Korshunov</name>
<affiliation wicri:level="3">
<nlm:aff id="A6"> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation>
<nlm:aff id="A7"> Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg.</nlm:aff>
<wicri:noCountry code="subfield">69120 Heidelberg.</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Kool, Marcel" sort="Kool, Marcel" uniqKey="Kool M" first="Marcel" last="Kool">Marcel Kool</name>
<affiliation wicri:level="3">
<nlm:aff id="A1"> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea> Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Cell</title>
<idno type="ISSN">0092-8674</idno>
<idno type="eISSN">1097-4172</idno>
<imprint>
<date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Amino Acid Sequence</term>
<term>Central Nervous System Neoplasms (classification)</term>
<term>Central Nervous System Neoplasms (diagnosis)</term>
<term>Central Nervous System Neoplasms (genetics)</term>
<term>Central Nervous System Neoplasms (pathology)</term>
<term>Child</term>
<term>DNA Methylation</term>
<term>Forkhead Transcription Factors (genetics)</term>
<term>Gene Expression Profiling</term>
<term>Gene Expression Regulation, Neoplastic</term>
<term>Humans</term>
<term>Molecular Sequence Data</term>
<term>Neuroectodermal Tumors (classification)</term>
<term>Neuroectodermal Tumors (diagnosis)</term>
<term>Neuroectodermal Tumors (genetics)</term>
<term>Neuroectodermal Tumors (pathology)</term>
<term>Proto-Oncogene Proteins (chemistry)</term>
<term>Proto-Oncogene Proteins (genetics)</term>
<term>Repressor Proteins (chemistry)</term>
<term>Repressor Proteins (genetics)</term>
<term>Signal Transduction</term>
<term>Tumor Suppressor Proteins (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Analyse de profil d'expression de gènes</term>
<term>Données de séquences moléculaires</term>
<term>Enfant</term>
<term>Facteurs de transcription Forkhead (génétique)</term>
<term>Humains</term>
<term>Méthylation de l'ADN</term>
<term>Protéines de répression ()</term>
<term>Protéines de répression (génétique)</term>
<term>Protéines proto-oncogènes ()</term>
<term>Protéines proto-oncogènes (génétique)</term>
<term>Protéines suppresseurs de tumeurs (génétique)</term>
<term>Régulation de l'expression des gènes tumoraux</term>
<term>Séquence d'acides aminés</term>
<term>Transduction du signal</term>
<term>Tumeurs du système nerveux central ()</term>
<term>Tumeurs du système nerveux central (anatomopathologie)</term>
<term>Tumeurs du système nerveux central (diagnostic)</term>
<term>Tumeurs du système nerveux central (génétique)</term>
<term>Tumeurs neuroectodermiques ()</term>
<term>Tumeurs neuroectodermiques (anatomopathologie)</term>
<term>Tumeurs neuroectodermiques (diagnostic)</term>
<term>Tumeurs neuroectodermiques (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en">
<term>Proto-Oncogene Proteins</term>
<term>Repressor Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en">
<term>Forkhead Transcription Factors</term>
<term>Proto-Oncogene Proteins</term>
<term>Repressor Proteins</term>
<term>Tumor Suppressor Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr">
<term>Tumeurs du système nerveux central</term>
<term>Tumeurs neuroectodermiques</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en">
<term>Central Nervous System Neoplasms</term>
<term>Neuroectodermal Tumors</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en">
<term>Central Nervous System Neoplasms</term>
<term>Neuroectodermal Tumors</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr">
<term>Tumeurs du système nerveux central</term>
<term>Tumeurs neuroectodermiques</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en">
<term>Central Nervous System Neoplasms</term>
<term>Neuroectodermal Tumors</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr">
<term>Facteurs de transcription Forkhead</term>
<term>Protéines de répression</term>
<term>Protéines proto-oncogènes</term>
<term>Protéines suppresseurs de tumeurs</term>
<term>Tumeurs du système nerveux central</term>
<term>Tumeurs neuroectodermiques</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en">
<term>Central Nervous System Neoplasms</term>
<term>Neuroectodermal Tumors</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Amino Acid Sequence</term>
<term>Child</term>
<term>DNA Methylation</term>
<term>Gene Expression Profiling</term>
<term>Gene Expression Regulation, Neoplastic</term>
<term>Humans</term>
<term>Molecular Sequence Data</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Analyse de profil d'expression de gènes</term>
<term>Données de séquences moléculaires</term>
<term>Enfant</term>
<term>Humains</term>
<term>Méthylation de l'ADN</term>
<term>Protéines de répression</term>
<term>Protéines proto-oncogènes</term>
<term>Régulation de l'expression des gènes tumoraux</term>
<term>Séquence d'acides aminés</term>
<term>Transduction du signal</term>
<term>Tumeurs du système nerveux central</term>
<term>Tumeurs neuroectodermiques</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<title>SUMMARY</title>
<p id="P2">Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly aggressive, poorly differentiated embryonal tumors occurring predominantly in young children but also affecting adolescents and adults. Herein we demonstrate that a significant proportion of institutionally diagnosed CNS-PNETs display molecular profiles indistinguishable from those of various other well-defined CNS tumor entities, facilitating diagnosis and appropriate therapy for patients with these tumors. From the remaining fraction of CNS-PNETs we identify four new CNS tumor entities, each associated with a recurrent genetic alteration and distinct histopathological and clinical features. These new molecular entities, designated “CNS neuroblastoma with
<italic>FOXR2</italic>
activation (CNS NB-
<italic>FOXR2</italic>
)”, “CNS Ewing sarcoma family tumor with
<italic>CIC</italic>
alteration (CNS EFT-
<italic>CIC</italic>
)”, “CNS high-grade neuroepithelial tumor with
<italic>MN1</italic>
alteration (CNS HGNET-
<italic>MN1</italic>
)”, and “CNS high-grade neuroepithelial tumor with
<italic>BCOR</italic>
alteration (CNS HGNET-
<italic>BCOR</italic>
)”, will enable meaningful clinical trials and the development of therapeutic strategies for patients affected by poorly differentiated CNS tumors.</p>
</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>Allemagne</li>
<li>Australie</li>
<li>Autriche</li>
<li>Canada</li>
<li>Danemark</li>
<li>France</li>
<li>Irlande (pays)</li>
<li>Israël</li>
<li>Italie</li>
<li>Pays-Bas</li>
<li>Pologne</li>
<li>Royaume-Uni</li>
<li>Russie</li>
<li>République tchèque</li>
<li>Suisse</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
<region>
<li>Angleterre</li>
<li>Angleterre de l'Est</li>
<li>Auvergne-Rhône-Alpes</li>
<li>Bade-Wurtemberg</li>
<li>Basse-Saxe</li>
<li>Bavière</li>
<li>Californie</li>
<li>Canton de Berne</li>
<li>Canton de Zurich</li>
<li>District de Basse-Franconie</li>
<li>District de Cologne</li>
<li>District de Düsseldorf</li>
<li>District de Fribourg-en-Brisgau</li>
<li>District de Haute-Bavière</li>
<li>District de Karlsruhe</li>
<li>District de Münster</li>
<li>District de Souabe</li>
<li>District fédéral central</li>
<li>Grand Londres</li>
<li>Géorgie (États-Unis)</li>
<li>Hambourg</li>
<li>Hollande-Septentrionale</li>
<li>Latium</li>
<li>Michigan</li>
<li>Missouri (État)</li>
<li>Ohio</li>
<li>Ontario</li>
<li>Pennsylvanie</li>
<li>Provence-Alpes-Côte d'Azur</li>
<li>Rhénanie-du-Nord-Westphalie</li>
<li>Rhône-Alpes</li>
<li>Saxe-Anhalt</li>
<li>Tennessee</li>
<li>Texas</li>
<li>Vienne (Autriche)</li>
<li>Virginie</li>
<li>État de New York</li>
<li>Île-de-France</li>
</region>
<settlement>
<li>Amsterdam</li>
<li>Augsbourg</li>
<li>Berne</li>
<li>Bonn</li>
<li>Cambridge</li>
<li>Düsseldorf</li>
<li>Fribourg-en-Brisgau</li>
<li>Göttingen</li>
<li>Hambourg</li>
<li>Heidelberg</li>
<li>Londres</li>
<li>Lyon</li>
<li>Magdebourg</li>
<li>Marseille</li>
<li>Moscou</li>
<li>Munich</li>
<li>Münster</li>
<li>Paris</li>
<li>Rome</li>
<li>Toronto</li>
<li>Vienne (Autriche)</li>
<li>Wurtzbourg</li>
<li>Zurich</li>
</settlement>
<orgName>
<li>Université Louis-et-Maximilien de Munich</li>
<li>Université d'Amsterdam</li>
<li>Université de Cambridge</li>
<li>Université de Toronto</li>
</orgName>
</list>
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<region name="Bade-Wurtemberg">
<name sortKey="Sturm, Dominik" sort="Sturm, Dominik" uniqKey="Sturm D" first="Dominik" last="Sturm">Dominik Sturm</name>
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<name sortKey="Balasubramanian, Gnanaprakash" sort="Balasubramanian, Gnanaprakash" uniqKey="Balasubramanian G" first="Gnanaprakash" last="Balasubramanian">Gnanaprakash Balasubramanian</name>
<name sortKey="Brabetz, Sebastian" sort="Brabetz, Sebastian" uniqKey="Brabetz S" first="Sebastian" last="Brabetz">Sebastian Brabetz</name>
<name sortKey="Buchhalter, Ivo" sort="Buchhalter, Ivo" uniqKey="Buchhalter I" first="Ivo" last="Buchhalter">Ivo Buchhalter</name>
<name sortKey="Capper, David" sort="Capper, David" uniqKey="Capper D" first="David" last="Capper">David Capper</name>
<name sortKey="Ebinger, Martin" sort="Ebinger, Martin" uniqKey="Ebinger M" first="Martin" last="Ebinger">Martin Ebinger</name>
<name sortKey="Eils, Roland" sort="Eils, Roland" uniqKey="Eils R" first="Roland" last="Eils">Roland Eils</name>
<name sortKey="Eils, Roland" sort="Eils, Roland" uniqKey="Eils R" first="Roland" last="Eils">Roland Eils</name>
<name sortKey="Eils, Roland" sort="Eils, Roland" uniqKey="Eils R" first="Roland" last="Eils">Roland Eils</name>
<name sortKey="Felsberg, Jorg" sort="Felsberg, Jorg" uniqKey="Felsberg J" first="Jörg" last="Felsberg">Jörg Felsberg</name>
<name sortKey="Fruhwald, Michael C" sort="Fruhwald, Michael C" uniqKey="Fruhwald M" first="Michael C." last="Frühwald">Michael C. Frühwald</name>
<name sortKey="Hagel, Christian" sort="Hagel, Christian" uniqKey="Hagel C" first="Christian" last="Hagel">Christian Hagel</name>
<name sortKey="Hans, Volkmar" sort="Hans, Volkmar" uniqKey="Hans V" first="Volkmar" last="Hans">Volkmar Hans</name>
<name sortKey="Hasselblatt, Martin" sort="Hasselblatt, Martin" uniqKey="Hasselblatt M" first="Martin" last="Hasselblatt">Martin Hasselblatt</name>
<name sortKey="Herold Mende, Christel" sort="Herold Mende, Christel" uniqKey="Herold Mende C" first="Christel" last="Herold-Mende">Christel Herold-Mende</name>
<name sortKey="Hovestadt, Volker" sort="Hovestadt, Volker" uniqKey="Hovestadt V" first="Volker" last="Hovestadt">Volker Hovestadt</name>
<name sortKey="Johann, Pascal D" sort="Johann, Pascal D" uniqKey="Johann P" first="Pascal D." last="Johann">Pascal D. Johann</name>
<name sortKey="Johann, Pascal D" sort="Johann, Pascal D" uniqKey="Johann P" first="Pascal D." last="Johann">Pascal D. Johann</name>
<name sortKey="Jones, David T W" sort="Jones, David T W" uniqKey="Jones D" first="David T. W." last="Jones">David T. W. Jones</name>
<name sortKey="Koelsche, Christian" sort="Koelsche, Christian" uniqKey="Koelsche C" first="Christian" last="Koelsche">Christian Koelsche</name>
<name sortKey="Kool, Marcel" sort="Kool, Marcel" uniqKey="Kool M" first="Marcel" last="Kool">Marcel Kool</name>
<name sortKey="Korshunov, Andrey" sort="Korshunov, Andrey" uniqKey="Korshunov A" first="Andrey" last="Korshunov">Andrey Korshunov</name>
<name sortKey="Kramm, Christof M" sort="Kramm, Christof M" uniqKey="Kramm C" first="Christof M." last="Kramm">Christof M. Kramm</name>
<name sortKey="Leis, Irina" sort="Leis, Irina" uniqKey="Leis I" first="Irina" last="Leis">Irina Leis</name>
<name sortKey="Lichter, Peter" sort="Lichter, Peter" uniqKey="Lichter P" first="Peter" last="Lichter">Peter Lichter</name>
<name sortKey="Lichter, Peter" sort="Lichter, Peter" uniqKey="Lichter P" first="Peter" last="Lichter">Peter Lichter</name>
<name sortKey="Mawrin, Christian" sort="Mawrin, Christian" uniqKey="Mawrin C" first="Christian" last="Mawrin">Christian Mawrin</name>
<name sortKey="Milde, Till" sort="Milde, Till" uniqKey="Milde T" first="Till" last="Milde">Till Milde</name>
<name sortKey="Milde, Till" sort="Milde, Till" uniqKey="Milde T" first="Till" last="Milde">Till Milde</name>
<name sortKey="Monoranu, Camelia Maria" sort="Monoranu, Camelia Maria" uniqKey="Monoranu C" first="Camelia-Maria" last="Monoranu">Camelia-Maria Monoranu</name>
<name sortKey="Northcott, Paul A" sort="Northcott, Paul A" uniqKey="Northcott P" first="Paul A." last="Northcott">Paul A. Northcott</name>
<name sortKey="Pajtler, Kristian W" sort="Pajtler, Kristian W" uniqKey="Pajtler K" first="Kristian W." last="Pajtler">Kristian W. Pajtler</name>
<name sortKey="Pfaff, Elke" sort="Pfaff, Elke" uniqKey="Pfaff E" first="Elke" last="Pfaff">Elke Pfaff</name>
<name sortKey="Pfaff, Elke" sort="Pfaff, Elke" uniqKey="Pfaff E" first="Elke" last="Pfaff">Elke Pfaff</name>
<name sortKey="Pfister, Stefan M" sort="Pfister, Stefan M" uniqKey="Pfister S" first="Stefan M." last="Pfister">Stefan M. Pfister</name>
<name sortKey="Pfister, Stefan M" sort="Pfister, Stefan M" uniqKey="Pfister S" first="Stefan M." last="Pfister">Stefan M. Pfister</name>
<name sortKey="Pietsch, Torsten" sort="Pietsch, Torsten" uniqKey="Pietsch T" first="Torsten" last="Pietsch">Torsten Pietsch</name>
<name sortKey="Prinz, Marco" sort="Prinz, Marco" uniqKey="Prinz M" first="Marco" last="Prinz">Marco Prinz</name>
<name sortKey="Reifenberger, Guido" sort="Reifenberger, Guido" uniqKey="Reifenberger G" first="Guido" last="Reifenberger">Guido Reifenberger</name>
<name sortKey="Ro Ler, Jochen" sort="Ro Ler, Jochen" uniqKey="Ro Ler J" first="Jochen" last="Rö Ler">Jochen Rö Ler</name>
<name sortKey="Rutkowski, Stefan" sort="Rutkowski, Stefan" uniqKey="Rutkowski S" first="Stefan" last="Rutkowski">Stefan Rutkowski</name>
<name sortKey="Sahm, Felix" sort="Sahm, Felix" uniqKey="Sahm F" first="Felix" last="Sahm">Felix Sahm</name>
<name sortKey="Scheurlen, Wolfram" sort="Scheurlen, Wolfram" uniqKey="Scheurlen W" first="Wolfram" last="Scheurlen">Wolfram Scheurlen</name>
<name sortKey="Schittenhelm, Jens" sort="Schittenhelm, Jens" uniqKey="Schittenhelm J" first="Jens" last="Schittenhelm">Jens Schittenhelm</name>
<name sortKey="Schlesner, Matthias" sort="Schlesner, Matthias" uniqKey="Schlesner M" first="Matthias" last="Schlesner">Matthias Schlesner</name>
<name sortKey="Schneppenheim, Reinhard" sort="Schneppenheim, Reinhard" uniqKey="Schneppenheim R" first="Reinhard" last="Schneppenheim">Reinhard Schneppenheim</name>
<name sortKey="Schuhmann, Martin U" sort="Schuhmann, Martin U" uniqKey="Schuhmann M" first="Martin U." last="Schuhmann">Martin U. Schuhmann</name>
<name sortKey="Schuller, Ulrich" sort="Schuller, Ulrich" uniqKey="Schuller U" first="Ulrich" last="Schüller">Ulrich Schüller</name>
<name sortKey="Sill, Martin" sort="Sill, Martin" uniqKey="Sill M" first="Martin" last="Sill">Martin Sill</name>
<name sortKey="Sturm, Dominik" sort="Sturm, Dominik" uniqKey="Sturm D" first="Dominik" last="Sturm">Dominik Sturm</name>
<name sortKey="Toprak, Umut H" sort="Toprak, Umut H" uniqKey="Toprak U" first="Umut H." last="Toprak">Umut H. Toprak</name>
<name sortKey="Von Bueren, Andre O" sort="Von Bueren, Andre O" uniqKey="Von Bueren A" first="André O." last="Von Bueren">André O. Von Bueren</name>
<name sortKey="Von Deimling, Andreas" sort="Von Deimling, Andreas" uniqKey="Von Deimling A" first="Andreas" last="Von Deimling">Andreas Von Deimling</name>
<name sortKey="Von Hoff, Katja" sort="Von Hoff, Katja" uniqKey="Von Hoff K" first="Katja" last="Von Hoff">Katja Von Hoff</name>
<name sortKey="Wolf, Stephan" sort="Wolf, Stephan" uniqKey="Wolf S" first="Stephan" last="Wolf">Stephan Wolf</name>
<name sortKey="Wolter, Marietta" sort="Wolter, Marietta" uniqKey="Wolter M" first="Marietta" last="Wolter">Marietta Wolter</name>
<name sortKey="Worst, Barbara C" sort="Worst, Barbara C" uniqKey="Worst B" first="Barbara C." last="Worst">Barbara C. Worst</name>
<name sortKey="Worst, Barbara C" sort="Worst, Barbara C" uniqKey="Worst B" first="Barbara C." last="Worst">Barbara C. Worst</name>
</country>
<country name="États-Unis">
<region name="Tennessee">
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</region>
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<name sortKey="Allen, Sariah J" sort="Allen, Sariah J" uniqKey="Allen S" first="Sariah J." last="Allen">Sariah J. Allen</name>
<name sortKey="Cowdrey, Cynthia" sort="Cowdrey, Cynthia" uniqKey="Cowdrey C" first="Cynthia" last="Cowdrey">Cynthia Cowdrey</name>
<name sortKey="Dahiya, Sonika" sort="Dahiya, Sonika" uniqKey="Dahiya S" first="Sonika" last="Dahiya">Sonika Dahiya</name>
<name sortKey="Drissi, Rachid" sort="Drissi, Rachid" uniqKey="Drissi R" first="Rachid" last="Drissi">Rachid Drissi</name>
<name sortKey="Ellison, David W" sort="Ellison, David W" uniqKey="Ellison D" first="David W." last="Ellison">David W. Ellison</name>
<name sortKey="Forrester, Lynn Ann" sort="Forrester, Lynn Ann" uniqKey="Forrester L" first="Lynn Ann" last="Forrester">Lynn Ann Forrester</name>
<name sortKey="Fouladi, Maryam" sort="Fouladi, Maryam" uniqKey="Fouladi M" first="Maryam" last="Fouladi">Maryam Fouladi</name>
<name sortKey="Gajjar, Amar" sort="Gajjar, Amar" uniqKey="Gajjar A" first="Amar" last="Gajjar">Amar Gajjar</name>
<name sortKey="Karajannis, Matthias A" sort="Karajannis, Matthias A" uniqKey="Karajannis M" first="Matthias A." last="Karajannis">Matthias A. Karajannis</name>
<name sortKey="Mikkelsen, Tom" sort="Mikkelsen, Tom" uniqKey="Mikkelsen T" first="Tom" last="Mikkelsen">Tom Mikkelsen</name>
<name sortKey="Mobley, Bret C" sort="Mobley, Bret C" uniqKey="Mobley B" first="Bret C." last="Mobley">Bret C. Mobley</name>
<name sortKey="Perry, Arie" sort="Perry, Arie" uniqKey="Perry A" first="Arie" last="Perry">Arie Perry</name>
<name sortKey="Perry, Arie" sort="Perry, Arie" uniqKey="Perry A" first="Arie" last="Perry">Arie Perry</name>
<name sortKey="Perry, Arie" sort="Perry, Arie" uniqKey="Perry A" first="Arie" last="Perry">Arie Perry</name>
<name sortKey="Phillips, Joanna J" sort="Phillips, Joanna J" uniqKey="Phillips J" first="Joanna J." last="Phillips">Joanna J. Phillips</name>
<name sortKey="Phillips, Joanna J" sort="Phillips, Joanna J" uniqKey="Phillips J" first="Joanna J." last="Phillips">Joanna J. Phillips</name>
<name sortKey="Phillips, Joanna J" sort="Phillips, Joanna J" uniqKey="Phillips J" first="Joanna J." last="Phillips">Joanna J. Phillips</name>
<name sortKey="Santi, Mariarita" sort="Santi, Mariarita" uniqKey="Santi M" first="Mariarita" last="Santi">Mariarita Santi</name>
<name sortKey="Schniederjan, Matthew J" sort="Schniederjan, Matthew J" uniqKey="Schniederjan M" first="Matthew J." last="Schniederjan">Matthew J. Schniederjan</name>
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<name sortKey="Van Meter, Timothy" sort="Van Meter, Timothy" uniqKey="Van Meter T" first="Timothy" last="Van Meter">Timothy Van Meter</name>
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<country name="Russie">
<region name="District fédéral central">
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</country>
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<name sortKey="Remke, Marc" sort="Remke, Marc" uniqKey="Remke M" first="Marc" last="Remke">Marc Remke</name>
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</country>
<country name="Italie">
<region name="Latium">
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<name sortKey="Buccoliero, Anna M" sort="Buccoliero, Anna M" uniqKey="Buccoliero A" first="Anna M." last="Buccoliero">Anna M. Buccoliero</name>
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</country>
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<country name="Israël">
<noRegion>
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<country name="République tchèque">
<noRegion>
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<name sortKey="Moore, Andrew S" sort="Moore, Andrew S" uniqKey="Moore A" first="Andrew S." last="Moore">Andrew S. Moore</name>
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